<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0375-0760</journal-id>
<journal-title><![CDATA[Revista Cubana de Medicina Tropical]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Med Trop]]></abbrev-journal-title>
<issn>0375-0760</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0375-07602021000300003</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Actividad citotóxica y antiproliferativa in vitro del extracto acuoso de Phyllanthus comosus]]></article-title>
<article-title xml:lang="en"><![CDATA[In vitro cytotoxic and antiproliferative activity of an aqueous extract from Phyllanthus comosus]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[del Barrio Alonso]]></surname>
<given-names><![CDATA[Gloria del Carmen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Morier Díaz]]></surname>
<given-names><![CDATA[Luis F.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Marrero]]></surname>
<given-names><![CDATA[Raúl Jorge]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de La Habana Facultad de Biología Departamento de Microbiología y Virología]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>73</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0375-07602021000300003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0375-07602021000300003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0375-07602021000300003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  Desde los inicios de la medicina antigua, las plantas han sido utilizadas como tratamiento en diversas enfermedades incluyendo las de naturaleza infecto-contagiosa y el cáncer. Son numerosos los informes sobre las propiedades biológicas del género Phyllanthus.  Objetivo:  Evaluar la actividad citotóxica y antiproliferativa de un extracto acuoso de Phyllanthus comosus en tres líneas celulares, dos de origen tumoral (SiHa y HeLa) y una no tumoral (Vero).  Métodos:  La actividad citotóxica se evaluó mediante el método del MTT y la capacidad antiproliferativa mediante el ensayo de detección de inhibición de colonias o clonogénico. Se tuvieron en cuenta valores como la concentración citotóxica media (CC50), índice selectivo y porcentaje de disminución de la proliferación celular.  Resultados:  En el ensayo de citotoxicidad se obtuvieron CC50 similares para ambas líneas tumorales; mientras que el valor para la línea Vero resultó tres veces menos tóxico, con valores de índice de selectividad mayor que tres. El ensayo clonogénico demostró inhibición de la proliferación en las líneas tumorales, mientras que en células Vero no se observó inhibición de la capacidad de formación de colonias.  Conclusiones:  El extracto de P. comosus es más citotóxico para las líneas tumorales SiHa y HeLa que para las células Vero, no tumorales. Además, la inhibición de la formación de clonos celulares en ambas líneas tumorales evidencia su acción antiproliferativa y selectiva, lo que argumenta su potencialidad antitumoral in vitro]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Ever since the onset of ancient medical practice, plants have been used to treat a variety of conditions, including infectious communicable diseases and cancer. A large number of reports are available about the biological properties of the genus Phyllantus.  Objective:  Evaluate the cytotoxic and antiproliferative activity of an aqueous extract of Phyllanthus comosus on three cell lines: two of tumoral origin (SiHa and HeLa) and one of non-tumoral origin (Vero).  Methods:  Cytotoxic activity was evaluated by the MTT method, and antiproliferative capacity by colony inhibition detection or clonogenic assay. Mean cytotoxic concentration (CC50), selective index and cell proliferation reduction percentage were some of the values taken into account.  Results:  The cytotoxicity assay obtained similar CC50 values for both tumor cell lines, whereas the value for the Vero line was three times less toxic, with a selectivity index above three. The clonogenic assay revealed proliferation inhibition in the tumor cell lines, whereas no inhibition of colony forming capacity was observed in Vero cells.  Conclusions:  The P. comosus extract is more cytotoxic for tumoral cell lines SiHa and HeLa than for non-tumor Vero cells. Additionally, inhibition of the formation of cell clones in both tumor cell lines is evidence of its antiproliferative and selective action, substantiating its in vitro antitumor potential.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[antiproliferativo]]></kwd>
<kwd lng="es"><![CDATA[antitumoral]]></kwd>
<kwd lng="es"><![CDATA[citotoxicidad]]></kwd>
<kwd lng="es"><![CDATA[ensayo clonogenico]]></kwd>
<kwd lng="es"><![CDATA[Phyllanthus comosus]]></kwd>
<kwd lng="en"><![CDATA[antiproliferative]]></kwd>
<kwd lng="en"><![CDATA[antitumor]]></kwd>
<kwd lng="en"><![CDATA[cytotoxicity]]></kwd>
<kwd lng="en"><![CDATA[clonogenic assay]]></kwd>
<kwd lng="en"><![CDATA[Phyllanthus comosus]]></kwd>
</kwd-group>
</article-meta>
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