<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0375-0760</journal-id>
<journal-title><![CDATA[Revista Cubana de Medicina Tropical]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Med Trop]]></abbrev-journal-title>
<issn>0375-0760</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0375-07602022000100006</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Identificación y evaluación de lesiones gástricas premalignas asociadas a la infección por Helicobacter pylori]]></article-title>
<article-title xml:lang="en"><![CDATA[Identification and evaluation of premalignant gastric lesions associated with Helicobacter pylori infection]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández López]]></surname>
<given-names><![CDATA[Elisa del Carmen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Villagrán Blanco]]></surname>
<given-names><![CDATA[Carmen Irene]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carías Alvarado]]></surname>
<given-names><![CDATA[César Camilo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández]]></surname>
<given-names><![CDATA[Beatriz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barrios Menéndez]]></surname>
<given-names><![CDATA[Juan Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez-Pérez]]></surname>
<given-names><![CDATA[Guillermo I.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de San Carlos de Guatemala Centro de Investigaciones Biomédicas Facultad de Ciencias Médicas]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Guatemala</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,New York University School of Medicine ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>USA</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de San Carlos de Guatemala  Facultad de Ciencias Médicas]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Guatemala</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Liga Nacional Contra el Cáncer Laboratorio de Investigación Biológica en Cáncer ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Guatemala</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2022</year>
</pub-date>
<volume>74</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0375-07602022000100006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0375-07602022000100006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0375-07602022000100006&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: La infección por Helicobacter pylori es la causa principal de enfermedades gastroduodenales (gastritis crónica, úlceras pépticas y cáncer gástrico). En Guatemala existen pocos estudios sobre la prevalencia de H. pylori y su relación con enfermedades gastrointestinales, particularmente con cáncer.  Objetivos: Identificar la presencia de lesiones premalignas (atrofia gástrica, metaplasia intestinal y displasia) y su relación con la infección por H. pylori en pacientes de consulta externa en unidades de gastroenterología de dos hospitales nacionales de la ciudad de Guatemala.  Métodos: El diagnóstico histopatológico y bacteriológico se realizó por medio de las tinciones de H &amp; E y Giemsa, cultivo e identificación bioquímica, detección de anticuerpos específicos mediante la prueba ELISA, diagnóstico molecular por la amplificación del gen glmM y genotipificación por PCR para identificar los genes VacA y CagA. Se analizaron datos clínico-epidemiológicos de los pacientes, la prevalencia de la infección por H. pylori y la genotipificación de la bacteria.  Resultados: En 293 de los pacientes estudiados (83 %) se encontró algún tipo de lesión premaligna; las más frecuentes fueron la atrofia gástrica (70 %), metaplasia intestinal (11 %) y displasia gástrica (2 %). El 17 % de los pacientes no presentó lesiones premalignas. Se halló una prevalencia de infección por H. pylori del 58 %, y el gen cagA se detectó en 118 (57 %) de los pacientes infectados.  Conclusiones: La mayoría de los pacientes presentó atrofia gástrica (70 %) y el 43,5 % estaba infectado por H. pylori, principalmente con cepas CagA positivo. Este hecho confirma la importancia del estudio de H. pylori y su relación con cáncer gástrico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: Helicobacter pylori infection is the main cause of gastroduodenal diseases (chronic gastritis, peptic ulcer and gastric cancer). In Guatemala few studies have been carried out on the prevalence of H. pylori and its relationship with gastrointestinal diseases, particularly with cancer.  Objective: To identify the presence of premalignant lesions (gastric atrophy, intestinal metaplasia and dysplasia) and their relationship with H. pylori infection in outpatients in gastroenterology units in two national hospitals in Guatemala City.  Methods: Histopathological and bacteriological diagnostic testings were performed by H &amp; E and Giemsa stain, culture and biochemical identification, detection of specific antibodies by ELISA, molecular diagnosis by glmM gene amplification, and genotypification by PCR to identify vacA and cagA genes. Clinical and epidemiological data from patients, prevalence of H. pylori infection, and bacterium genotypification were analyzed.  Results: Among the studied patients, 293 (83%) presented some type of premalignant lesion. The most prevalent were gastric atrophy (70%), intestinal metaplasia (11%), and gastric dysplasia (2%). Seventeen percent of the patients did not have any premalignant lesions. The prevalence of H. pylori infection was 58%, and cagA gene was identified in 118 (57%) of the infected patients.  Conclusions: The majority of the patients presented gastric atrophy (70%), and 43.5% were infected by H. pylori, mainly with positive cagA strains. This finding confirms the importance of studying H. pylori and its relationship with gastric cancer.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[atrofia gástrica]]></kwd>
<kwd lng="es"><![CDATA[metaplasia intestinal]]></kwd>
<kwd lng="es"><![CDATA[displasia epitelial]]></kwd>
<kwd lng="es"><![CDATA[CagA]]></kwd>
<kwd lng="es"><![CDATA[VacA]]></kwd>
<kwd lng="en"><![CDATA[gastric atrophy]]></kwd>
<kwd lng="en"><![CDATA[intestinal mataplasia]]></kwd>
<kwd lng="en"><![CDATA[epithelial dysplasia]]></kwd>
<kwd lng="en"><![CDATA[cagA]]></kwd>
<kwd lng="en"><![CDATA[vacA]]></kwd>
</kwd-group>
</article-meta>
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