<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0375-0760</journal-id>
<journal-title><![CDATA[Revista Cubana de Medicina Tropical]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Med Trop]]></abbrev-journal-title>
<issn>0375-0760</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0375-07602022000100008</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Bacterioma en nódulos mamarios y sus efectos morfológicos sobre la línea celular del cáncer de mama]]></article-title>
<article-title xml:lang="en"><![CDATA[Bacterioma in Mammary Nodules and Their Morphological Effects on Breast Cancer Cell Line]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pertuz Yepes]]></surname>
<given-names><![CDATA[Katia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sierra Hernández]]></surname>
<given-names><![CDATA[Adriana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz Yunez]]></surname>
<given-names><![CDATA[Israel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Escobar Pérez]]></surname>
<given-names><![CDATA[Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[De Nubbila]]></surname>
<given-names><![CDATA[Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Metropolitana Grupo de Proteómica y Genómica ]]></institution>
<addr-line><![CDATA[ Barranquilla]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,CEDIUL S.A.S. Imágenes diagnósticas y terapéuticas  ]]></institution>
<addr-line><![CDATA[ Barranquilla]]></addr-line>
<country>Colombia</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad del Bosque  ]]></institution>
<addr-line><![CDATA[ Bogotá]]></addr-line>
<country>Colombia</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2022</year>
</pub-date>
<volume>74</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0375-07602022000100008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0375-07602022000100008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0375-07602022000100008&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: En el cáncer de mama no se ha reportado una bacteria como causante, pero sí la presencia de diferentes especies que se relacionan de forma beneficiosa o perjudicial.  Objetivo: Identificar la microbiota presente en nódulos mamarios y sus efectos morfológicos sobre la línea celular MCF-7.  Métodos: Estudio exploratorio experimental de una población de 57 mujeres con nódulos mamarios, intervenidas para biopsia por punción en un centro de diagnóstico. De estas, se escogieron 17 muestras mediante muestreo no probabilístico para el análisis metagenómico. Se realizó una infección con células MCF-7 y Staphylococcus saprophyticus a MOI de 1:1, 5:1 y 10:1 (48 horas de exposición).  Resultados: De las 57 muestras tomadas, solo en 7 pacientes se obtuvo resultado positivo (12,28 %) y en el resto (50) no hubo crecimiento bacteriano. Por metagenómica se obtuvo la microbiota siguiente: Proteobacteria (47 %), Escherichia (9,4 %) y Yokenella (8,2 %), entre otros. Los controles fueron negativos. Solo dos pacientes resultaron positivas para cáncer, entre ellas la especie común fue S. saprophyticus. En la infección, los cambios morfológicos se evidenciaron desde la MOI 5:1.  Conclusión: El bacterioma extraído de los nódulos de una población femenina es en su mayoría flora endógena del órgano mamario.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: No bacterium has been reported as causative of breast cancer, but the presence of different species that are related in a beneficial or detrimental way.  Objective: To identify the microbiota present in breast nodules and its morphological effects on the MCF-7 cell line.  Methods: Exploratory, experimental study of a population of 57 women with breast nodules, operated for needle biopsy in a diagnostic center. Of these, 17 samples were chosen by non-probabilistic sampling for metagenomic analysis. Infection was performed with MCF-7 cells and Staphylococcus saprophyticus at MOI of 1:1, 5:1 and 10:1 (48 hours of exposure).  Results: Of the 57 samples taken, only 7 yielded positive results (12.28%) and the rest (50) had no bacterial growth. The following microbiota was obtained by metagenomics: Proteobacteria (47%), Escherichia (9.4%) and Yokenella (8.2%), among others. Controls were negative. Only two patients tested positive for cancer, and S. saprophyticus was the common species. In the infection, morphological changes were evidenced from MOI 5:1.  Conclusion: The bacteriome extracted from the nodules of a female population is mostly endogenous flora of the mammary glands.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[bacterias]]></kwd>
<kwd lng="es"><![CDATA[nódulos]]></kwd>
<kwd lng="es"><![CDATA[metagenómico]]></kwd>
<kwd lng="es"><![CDATA[MCF-7]]></kwd>
<kwd lng="en"><![CDATA[bacteria]]></kwd>
<kwd lng="en"><![CDATA[nodules]]></kwd>
<kwd lng="en"><![CDATA[metagenomics]]></kwd>
<kwd lng="en"><![CDATA[MCF-7]]></kwd>
</kwd-group>
</article-meta>
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