<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0864-0289</journal-id>
<journal-title><![CDATA[Revista Cubana de Hematología, Inmunología y Hemoterapia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Hematol Inmunol Hemoter]]></abbrev-journal-title>
<issn>0864-0289</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias MédicasEditorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0864-02892019000100005</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Anticuerpos antiplaquetarios en pacientes cubanos en espera de trasplante renal]]></article-title>
<article-title xml:lang="en"><![CDATA[Platelet antibodies in cuban patients waiting for renal transplantation]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Soler Noda]]></surname>
<given-names><![CDATA[Gilberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Romero Díaz]]></surname>
<given-names><![CDATA[Yisenia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bencomo Hernández]]></surname>
<given-names><![CDATA[Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto de Hematología e Inmunología  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2019</year>
</pub-date>
<volume>35</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0864-02892019000100005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0864-02892019000100005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0864-02892019000100005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: Los antígenos específicos de plaquetas, conocidos como antígenos de plaquetas humanas (HPA, del inglés human platelet antigens), se incluyen dentro del espectro de antígenos de histocompatibilidad no-HLA, debido a que los anticuerpos anti-HPA participan en el rechazo del trasplante, además de ser causa del fenómeno de refractariedad plaquetaria.  Objetivo:  Caracterizar los anticuerpos contra antígenos específicos de plaquetas en pacientes cubanos en espera de trasplante renal.  Métodos:  Se investigaron muestras de sangre de 901 pacientes mediante la técnica de inmovilización de antígenos plaquetarios con anticuerpos monoclonales.  Resultados:  En 78 pacientes se detectaron anticuerpos anti-HPA, que en el 87,17 % reconocían los antígenos presentes en el complejo GP-IIb/IIIa. Estos anticuerpos fueron del tipo IgG en el 78,2 %, IgA en el 11,53 % e IgM en el 46,15 %.  Conclusiones:  En pacientes cubanos en espera de trasplante renal son frecuentes los Ac anti-HPA, en su mayoría del tipo IgG dirigidos contra antígenos presentes en el complejo GP-IIb/IIIa.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: Platelet-specific antigens, known as human platelet antigens (HPA), are included within the spectrum of non-HLA histocompatibility antigens, because HPA antibodies participate in the rejection of transplantation, besides being a cause of the phenomenon of platelet refractoriness.  Objective:  To characterize antibodies against platelet-specific antigens in Cuban patients awaiting kidney transplantation.  Methods: The technique &#8220;monoclonal antibodies immobilized platelets antigens" was applied to blood samples from 901 patients.  Results: HPA antibodies were detected in 78 patients, which in 87.17 % recognized the antigens present in the GP-IIb / IIIa complex. These antibodies were in 78.2 % of the IgG class, in 11.53 % IgA and IgM in 46.15 %.  Conclusions: HPA antibodies, mostly of the IgG class and directed to antigens present in the GP-IIb/IIIa complex, are common in Cuban patients awaiting kidney transplantation.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[antígenos de plaquetas humanas]]></kwd>
<kwd lng="es"><![CDATA[HPA]]></kwd>
<kwd lng="es"><![CDATA[anticuerpos anti-HPA]]></kwd>
<kwd lng="es"><![CDATA[aloinmunización]]></kwd>
<kwd lng="es"><![CDATA[refractariedad plaquetaria]]></kwd>
<kwd lng="es"><![CDATA[trasplante renal]]></kwd>
<kwd lng="en"><![CDATA[human platelet antigens]]></kwd>
<kwd lng="en"><![CDATA[HPA]]></kwd>
<kwd lng="en"><![CDATA[anti-HPA antibodies]]></kwd>
<kwd lng="en"><![CDATA[alloimmunization]]></kwd>
<kwd lng="en"><![CDATA[platelet refractoriness]]></kwd>
<kwd lng="en"><![CDATA[kidney transplantation]]></kwd>
</kwd-group>
</article-meta>
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<given-names><![CDATA[AK]]></given-names>
</name>
<name>
<surname><![CDATA[Lichtman]]></surname>
<given-names><![CDATA[AH]]></given-names>
</name>
<name>
<surname><![CDATA[Pillai]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Cellular and molecular immunology]]></source>
<year>2017</year>
<edition>9</edition>
<publisher-loc><![CDATA[San London ]]></publisher-loc>
<publisher-name><![CDATA[Elsevier]]></publisher-name>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
