<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0864-0289</journal-id>
<journal-title><![CDATA[Revista Cubana de Hematología, Inmunología y Hemoterapia]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Hematol Inmunol Hemoter]]></abbrev-journal-title>
<issn>0864-0289</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias MédicasEditorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0864-02892021000400009</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Caracterización del hemograma completo en adultos mayores cubanos tratados con Biomodulina T®]]></article-title>
<article-title xml:lang="en"><![CDATA[Characterization of the complete blood count of Cuban older adults treated with Biomodulina T®]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Simón Pita]]></surname>
<given-names><![CDATA[Ana María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández Rego]]></surname>
<given-names><![CDATA[Yaquima]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández Ramos]]></surname>
<given-names><![CDATA[Elizabeth]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Marsán Suárez]]></surname>
<given-names><![CDATA[Vianed]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Triana Marrero]]></surname>
<given-names><![CDATA[Yenisey]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes Zamora]]></surname>
<given-names><![CDATA[Mari Carmen]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Macías Abraham]]></surname>
<given-names><![CDATA[Consuelo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto de Hematología e Inmunología  ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Nacional de Biopreparados (BIOCEN)  ]]></institution>
<addr-line><![CDATA[ Mayabeque]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2021</year>
</pub-date>
<volume>37</volume>
<numero>4</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0864-02892021000400009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0864-02892021000400009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0864-02892021000400009&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  Durante las últimas décadas es evidente el aumento progresivo de los adultos mayores en Cuba. El proceso de envejecimiento provoca cambios en el sistema inmune que afectan su funcionamiento y desarrollo.  Objetivo:  Caracterizar parámetros hematológicos e inmunológicos mediante el hemograma completo en adultos mayores cubanos antes y después de la administración de la Biomodulina T®.  Métodos: Se realizó un estudio descriptivo y observacional para evaluar el efecto de la Biomodulina T® sobre los parámetros del hemograma completo. Se utilizó el paquete estadístico GraphPad Prism (versión 6.00). Los datos que presentaban una distribución normal, se procesaron utilizando la t Student. La prueba de rangos con signo de Wilcoxon se empleó cuando los datos no cumplían una distribución normal, ambos para un nivel de significación de p &lt; 0,05.  Resultados:  Predominaron las mujeres en relación a los hombres, que representó 27,6 %. Hubo superioridad de adultos mayores de 76-80 años de edad. El conteo global de leucocitos se mantuvo dentro de parámetros normales y solo en 5 pacientes disminuyeron las plaquetas después de la administración de Biomodulina T. Estos resultados no fueron estadísticamente significativos.  Conclusiones:  Se demostró que el tratamiento con Biomodulina T® no modifica los diferentes parámetros del hemograma completo en el adulto mayor.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  In the last decade it has been evident the rise in the older adults in Cuba. The process of aging causes changes in the immune system that affects the development and function.  Objective:  To characterize hematological and immunological parameters by means of the complete blood count in Cuban older adults before and after the administration of Biomodulin T®  Materials and methods:  A descriptive and observational study was to conducted to evaluate the use of Biomodulina T, the statistic package used was the GraphPad Prism (version 6.00). The data that showed a normal distribution were processed using the Student´s t test. The Wilcoxon´s signed range test with was used when the data did not comply with the normal distribution. Both for a signification level of p &lt; 0.05.  Results:  Women predominated in relation to men, representing 27.6%. There was a predominance of older adults aged 76-80 years. The global leukocyte count remained within normal parameters and platelets decreased only in 5 patients after the administration of Biomodulina T, that results were not statistically significant.  Conclusion:  It was shown that the Biomodulina T did not modify the hemogram results in the elderly patients.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[hemograma completo]]></kwd>
<kwd lng="es"><![CDATA[BiomodulinaT]]></kwd>
<kwd lng="es"><![CDATA[adulto mayor]]></kwd>
<kwd lng="en"><![CDATA[complete blood count]]></kwd>
<kwd lng="en"><![CDATA[Biomodulina T]]></kwd>
<kwd lng="en"><![CDATA[elderly]]></kwd>
</kwd-group>
</article-meta>
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