<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0864-0300</journal-id>
<journal-title><![CDATA[Revista Cubana de Investigaciones Biomédicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Invest Bioméd]]></abbrev-journal-title>
<issn>0864-0300</issn>
<publisher>
<publisher-name><![CDATA[ECIMED]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0864-03002019000300006</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Neuroimmunological approach for evaluation of viral measles, mumps and rubella (MMR) triple vaccine]]></article-title>
<article-title xml:lang="es"><![CDATA[Enfoque neuroinmunológico para la evaluación de la vacuna triple vírica contra el sarampión, la parotiditis y la rubéola]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castillo González]]></surname>
<given-names><![CDATA[William]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cruz Quevedo]]></surname>
<given-names><![CDATA[Mileydis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Pérez]]></surname>
<given-names><![CDATA[José Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barrios Lamoth]]></surname>
<given-names><![CDATA[Eneida]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Losada]]></surname>
<given-names><![CDATA[Cristóbal]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Dorta Contreras]]></surname>
<given-names><![CDATA[Alberto Juan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Facultad de Ciencias Médicas &#8220;Miguel Enríquez&#8221; Laboratorio Central de Líquido Cefalorraquídeo (LABCEL) ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana Instituto de Ciencias Básicas y Preclínicas &#8220;Victorias de Girón&#8221; ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2019</year>
</pub-date>
<volume>38</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0864-03002019000300006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0864-03002019000300006&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0864-03002019000300006&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  During the neuroinflammatory processes there are a poly-specific and polyclonal activation in the cerebrospinal fluid. It means that there can be quantified antibodies against all the components of the vaccines may have received.  Objective: To evaluate the immune response against measles, mumps and rubella in vaccinated pediatric patients.  Methods: All the serum and cerebrospinal fluid (CSF) paired samples from pediatric patients with neurological symptoms, that were submitted to hospitals from Havana City and were performed a lumbar puncture, were collected. Serum and CSF IgG, albumin were measured by immune-diffusion techniques using NOR and LC Partigen Immunoplates (Siemens, Marburg) and specific antibodies against measles, mumps and rubella were quantified by ELISA kits (Enzygnost, Siemens, Marburg). Reibergrams were employed in order to determine if there was IgG intrathecal synthesis. Later on, antibody index against the specific virus were calculated.  Results:  In all the neuroimmune inflammation process were found antibody index against measles, mumps and rubella in a different ample confidence variation among the different virus. Antibodies against mumps are significantly different from the other ones. It could be due to a natural different immune response or due to a deficient vaccine quality lot. Also it was possible to identify six pediatric patients that had no immune antibody index at all. It coincides with a transient hypogammaglobulinemia of infancy in such patients. Conclusions: This neuroimmunological approach can be used to evaluate the immune status in pediatric population.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  Durante los procesos neuroinflamatorios se produce una activación poliespecífica y policlonal en el líquido cefalorraquídeo. Eso significa que pueden existir anticuerpos cuantificados contra todos los componentes de las vacunas que se reciban.  Objetivo:  Evaluar la respuesta inmune contra el sarampión, las paperas y la rubéola en pacientes pediátricos vacunados.  Métodos:  Se recogieron muestras pareadas de suero y líquido cefalorraquídeo (LCR) de pacientes pediátricos con síntomas neurológicos mediante punciones lumbares realizadas en hospitales de Ciudad de La Habana. El IgG y la albúmina del suero y el LCR fueron medidos con técnicas de inmunodifusión usando inmunoplacas Partigen NOR y LC (Siemens, Marburgo). Los anticuerpos específicos contra el sarampión, la parotiditis y la rubéola se cuantificaron con dispositivos para ELISA (Enzygnost, Siemens, Marburgo). Se utilizaron reibergramas para determinar la presencia de síntesis intratecal de IgG. Seguidamente se calculó el índice de anticuerpos contra el virus específico.  Resultados:  En todos los procesos de inflamación neuroinmune se encontraron índices de anticuerpos contra el sarampión, la parotiditis y la rubéola con una variación amplia y diferente entre los distintos virus. Los anticuerpos contra la parotiditis son significativamente diferentes a los demás, lo que puede deberse a una respuesta inmune natural distinta o a una deficiente calidad de las vacunas. También fue posible identificar a seis pacientes pediátricos en los que no se observó ningún índice de anticuerpos inmunes, en coincidencia con la presencia de hipogammaglobulinemia transitoria infantil en esos pacientes.  Conclusiones:  El enfoque neuroinmunológico que se describe puede usarse para evaluar el estado inmunológico de la población pediátrica.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[neuroimmunology]]></kwd>
<kwd lng="en"><![CDATA[triple vaccine]]></kwd>
<kwd lng="en"><![CDATA[antibody index]]></kwd>
<kwd lng="es"><![CDATA[neuroinmunología]]></kwd>
<kwd lng="es"><![CDATA[vacuna triple]]></kwd>
<kwd lng="es"><![CDATA[índice de anticuerpos]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reiber]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Cerebrospinal fluid data compilation and knowledge-based interpretation of bacterial, viral, parasitic, oncological, chronic inflammatory and demyelinating diseases. Diagnostic patterns not to be missed in neurology and psychiatry]]></article-title>
<source><![CDATA[Arquivos de Neuro-Psiquiatria]]></source>
<year>2016</year>
<volume>74</volume>
<page-range>337-50</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kliegman]]></surname>
<given-names><![CDATA[RM]]></given-names>
</name>
<name>
<surname><![CDATA[Berhman]]></surname>
<given-names><![CDATA[RE]]></given-names>
</name>
<name>
<surname><![CDATA[Jenson Hal]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Stanton Bonita]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<source><![CDATA[Tratado de Pediatría]]></source>
<year>2013</year>
<edition>19a</edition>
<publisher-loc><![CDATA[Barcelona ]]></publisher-loc>
<publisher-name><![CDATA[Elseiver]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Black]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<source><![CDATA[Microbiology. Principles and Explorations]]></source>
<year>2014</year>
<publisher-loc><![CDATA[Boston ]]></publisher-loc>
<publisher-name><![CDATA[John Wiley &amp; Sons, Inc]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dorta]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pattern of intrathecal immunoglobulin synthesis in pediatric patients with infectious meningoencephalitis]]></article-title>
<source><![CDATA[Biotecnología Aplicada]]></source>
<year>2006</year>
<volume>23</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>383-7</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Eroglu]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Aerts Kaya]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Cagdas]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Yilmaz]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[B lymphocyte subsets and outcomes in patients with an initial diagnosis of transient hypogammaglobulinemia of infancy]]></article-title>
<source><![CDATA[Scand J Immunol]]></source>
<year>2018</year>
<volume>88</volume>
<numero>4</numero>
<issue>4</issue>
</nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Robinson Agramonte]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Hansotto]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Cabrera Gomez]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Galvizu]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Intrathecal polyspecific immune response to neurotropic viruses in multiple esclerosis: a comparative report from Cuban patients]]></article-title>
<source><![CDATA[Acta Neurol Scand]]></source>
<year>2007</year>
<volume>115</volume>
<page-range>312-8</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Castillo González]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[González Losada]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Iglesias González]]></surname>
<given-names><![CDATA[IM]]></given-names>
</name>
<name>
<surname><![CDATA[Dorta Contreras]]></surname>
<given-names><![CDATA[AJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pesquisa inmuno-epidemiológica en niños con meningoencefalitis vírica vacunados contra la parotiditis, rubeola y sarampión]]></article-title>
<source><![CDATA[Vaccimonitor]]></source>
<year>2019</year>
<volume>28</volume>
<page-range>19-28</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Abbas]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Litchman]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Pillai]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<source><![CDATA[Cellular and Molecular Immunology]]></source>
<year>2014</year>
<edition>8th</edition>
<page-range>544</page-range><publisher-name><![CDATA[Elsevier]]></publisher-name>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
