<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0864-0300</journal-id>
<journal-title><![CDATA[Revista Cubana de Investigaciones Biomédicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Invest Bioméd]]></abbrev-journal-title>
<issn>0864-0300</issn>
<publisher>
<publisher-name><![CDATA[ECIMED]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0864-03002019000300009</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[The effects of microgravity exposure on maximal oxygen consumption in humans]]></article-title>
<article-title xml:lang="es"><![CDATA[Efectos de la exposición a la microgravedad en el consumo máximo de oxígeno de los humanos]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferretti]]></surname>
<given-names><![CDATA[Guido]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Université de Genève Department of Anesthesiology ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Switzerland</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,University of Brescia Department of Molecular and Translational Medicine ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Italy</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2019</year>
</pub-date>
<volume>38</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0864-03002019000300009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0864-03002019000300009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0864-03002019000300009&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT After a short summary of the multifactorial models of maximal O2 consumption (VO2max) limitation, microgravity exposure is discussed as a convenient experimental condition to test these models. The following points are highlighted: 1) The decrease of (VO2max) in microgravity concerns specifically exercise performed in upright posture upon resumption of gravity exposure; 2) The decrease of (VO2max) after microgravity exposure has two components: one is fast and is related to cardiovascular adaptation, the other is slow and is related to the development of muscle atrophy; 3) (VO2max) does not decrease during microgravity or in supine posture upon resumption of gravity exposure, if the time in microgravity is sufficiently short; 4) cardiovascular oxygen transport accounts for 70% of (VO2max) limitation also after microgravity exposure.]]></p></abstract>
<abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN Luego de un breve resumen de los modelos multifactoriales de la limitación del consumo máximo de oxígeno (VO2max), se analiza la exposición a la microgravedad como condición experimental conveniente para evaluar tales modelos. Se destacan los siguientes aspectos: 1) El decrecimiento en la microgravedad tiene que ver específicamente con los ejercicios realizados en posición vertical después de reanudar la exposición a la gravedad; 2) El decrecimiento posterior a la exposición a la microgravedad tiene dos componentes: uno es rápido y está relacionado con la adaptación cardiovascular, el otro es lento y está relacionado con la aparición de la atrofia muscular; 3) No decrece durante la microgravedad o en posición supina después de reanudarse la exposición a la gravedad, siempre que el tiempo transcurrido en microgravedad sea suficientemente corto; 4) el transporte de oxígeno cardiovascular representa el 70 % de la limitación también después de la exposición a la microgravedad.]]></p></abstract>
<kwd-group>
<kwd lng="en"><![CDATA[microgravity]]></kwd>
<kwd lng="en"><![CDATA[exercise]]></kwd>
<kwd lng="en"><![CDATA[cardiovascular oxygen transport]]></kwd>
<kwd lng="en"><![CDATA[muscle atrophy]]></kwd>
<kwd lng="en"><![CDATA[models]]></kwd>
<kwd lng="es"><![CDATA[microgravedad]]></kwd>
<kwd lng="es"><![CDATA[ejercicios]]></kwd>
<kwd lng="es"><![CDATA[transporte de oxígeno cardiovascular]]></kwd>
<kwd lng="es"><![CDATA[atrofia muscular]]></kwd>
<kwd lng="es"><![CDATA[modelos]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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