<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0864-0300</journal-id>
<journal-title><![CDATA[Revista Cubana de Investigaciones Biomédicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Invest Bioméd]]></abbrev-journal-title>
<issn>0864-0300</issn>
<publisher>
<publisher-name><![CDATA[ECIMED]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0864-03002020000300016</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Eficacia de la profilaxis antibiótica en la prevención de infecciones posquirúrgicas en la cirugía del tercer molar impactado]]></article-title>
<article-title xml:lang="en"><![CDATA[Efficacy of antibiotic prophylaxis to prevent postoperative infections in impacted third molar surgery]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castro-Rodríguez]]></surname>
<given-names><![CDATA[Yuri]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chumpitaz-Cerrate]]></surname>
<given-names><![CDATA[Víctor]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chávez-Rimache]]></surname>
<given-names><![CDATA[Lesly]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Mayor de San Marcos Facultad de Odontología ]]></institution>
<addr-line><![CDATA[Lima ]]></addr-line>
<country>Peru</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2020</year>
</pub-date>
<volume>39</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0864-03002020000300016&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0864-03002020000300016&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0864-03002020000300016&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La profilaxis antibiótica es controvertida, además que su uso inapropiado expone a los pacientes en riesgo de reacciones adversas y desarrollo de resistencia bacteriana.  Objetivo:  Realizar una revisión sistemática de ensayos clínicos aleatorizados que evaluaron le eficacia de la profilaxis antibiótica en la reducción de infecciones posoperatorias luego de la extracción de terceros molares impactados.  Métodos: Fueron utilizadas las bases de datos ScienceDirect, Clinical trials.gov y Scopus para ubicar ensayos clínicos. Las variables primarias incluyeron: presencia de infecciones posoperatorias (de la herida y/o alveolitis), reacciones adversas, trismo y dolor. Se realizó un metaanálisis con los estudios homogéneos a través del análisis de efectos aleatorios. El riesgo de sesgo de los ensayos incluidos fue evaluado a través de la guía Cochrane. El riesgo relativo global fue calculado utilizando el enfoque del inverso de la varianza con el método de efectos aleatorios.  Resultados: Fueron analizados cualitativamente 14 ensayos clínicos y 9 cuantitativamente. De un total de 874 pacientes, 49 (5,6 %) presentaron infecciones posoperatorias (16/446 para el grupo experimental y 33/428 para el grupo placebo). El metaanálisis arrojó un riesgo relativo global de 0,5 (IC 95 %: 0,27-0,94). El riesgo de sesgo para los estudios que utilizaron solo amoxicilina como medida profiláctica fue de 0,53 (IC 95 %: 0,27-1,03). Las principales reacciones adversas incluyeron: diarreas, reacciones gastrointestinales, fiebre y dolor gástrico.  Conclusiones: Los antibióticos sistémicos administrados antes de la cirugía fueron eficaces para reducir las frecuencias de aparición de infecciones posoperatorias luego de la extracción de terceros molares impactados.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Antibiotic prophylaxis is controversial, and its inappropriate use exposes patients to the risk of adverse reactions and the development of bacterial resistance.  Objective:  Carry out a systematic review of randomized clinical trials evaluating the efficacy of antibiotic prophylaxis for the reduction of postoperative infections after extraction of impacted third molars.  Methods: The search for clinical trials was conducted in the databases ScienceDirect, Clinicaltrials.gov and Scopus. The primary variables considered were presence of postoperative infections (of the wound and/or alveolitis), adverse reactions, trismus and pain. A meta-analysis was made of homogeneous studies applying the random effects model. The risk of bias in the trials included was evaluated using the Cochrane guide. The inverse variance approach and the random effects method were used for estimation of the global relative risk.  Results: Fourteen clinical trials were analyzed qualitatively and 9 quantitatively. Of the total 874 patients, 49 (5.6%) developed postoperative infections (16 / 446 for the experimental group and 33 / 428 for the placebo group). The meta-analysis found a global relative risk of 0,5 (CI 95 %: 0,27-0,94). Bias risk for studies using only amoxicillin as a prophylactic measure was 0,53 (CI 95 %: 0,27-1,03). The main adverse reactions were diarrhea, gastrointestinal reactions, fever and abdominal pain.  Conclusions: The systemic antibiotics administered before the surgery were effective to reduce the frequency of appearance of postoperative infections after extraction of impacted third molars.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[metaanálisis]]></kwd>
<kwd lng="es"><![CDATA[profilaxis antibiótica]]></kwd>
<kwd lng="es"><![CDATA[tercer molar]]></kwd>
<kwd lng="es"><![CDATA[alveolo seco]]></kwd>
<kwd lng="es"><![CDATA[cirugía bucal]]></kwd>
<kwd lng="en"><![CDATA[meta-analysis]]></kwd>
<kwd lng="en"><![CDATA[antibiotic prophylaxis]]></kwd>
<kwd lng="en"><![CDATA[third molar]]></kwd>
<kwd lng="en"><![CDATA[dry socket]]></kwd>
<kwd lng="en"><![CDATA[oral surgery]]></kwd>
</kwd-group>
</article-meta>
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