<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0864-0300</journal-id>
<journal-title><![CDATA[Revista Cubana de Investigaciones Biomédicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Invest Bioméd]]></abbrev-journal-title>
<issn>0864-0300</issn>
<publisher>
<publisher-name><![CDATA[ECIMED]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0864-03002021000200009</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Actividad antibacteriana y antifúngica del aceite esencial de Minthostachys mollis frente a microorganismos de la cavidad oral]]></article-title>
<article-title xml:lang="en"><![CDATA[Antibacterial and Antifungal Activity of the essential oil of Minthostachys mollis against oral microorganisms]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Paucar-Rodriguez]]></surname>
<given-names><![CDATA[Elizabeth]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peltroche-Adrianzen]]></surname>
<given-names><![CDATA[Nimia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cayo-Rojas]]></surname>
<given-names><![CDATA[César Félix]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
<xref ref-type="aff" rid="A a"/>
<xref ref-type="aff" rid="A3"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Nacional Federico Villarreal Facultad de Odontología ]]></institution>
<addr-line><![CDATA[Lima ]]></addr-line>
<country>Peru</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Nacional Federico Villarreal Escuela de Posgrado ]]></institution>
<addr-line><![CDATA[Lima ]]></addr-line>
<country>Peru</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Privada San Juan Bautista Escuela de Estomatología ]]></institution>
<addr-line><![CDATA[Lima ]]></addr-line>
<country>Peru</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2021</year>
</pub-date>
<volume>40</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0864-03002021000200009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0864-03002021000200009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0864-03002021000200009&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La Minthostachys mollises una planta aromática que crece en América Latina y produce aceites esenciales con acción antimicrobiana.  Objetivo:  Determinar la actividad del aceite esencial de Minthostachys mollis en diferentes concentraciones, comparado con doxiciclina y fluconazol frente a Porphyromonas gingivalis, Staphylococcus aureus y Candida albicans, a las 24, 48 y 72 horas.  Métodos:  Se realiza estudio experimental in vitro y longitudinal. Se prepararon 15 pocillos por subgrupo para evaluar el efecto inhibitorio de todas las concentraciones, dando un total de 360 pocillos. Por cromatografía de gases acoplada a espectrometría de masas se identificaron los componentes químicos del aceite esencial. Se analizó el efecto inhibitorio por el método de difusión de Kirby-Bauer en Agar Columbia y Agar Muller Hinton. El análisis estadístico se realizó mediante la prueba ANOVA y Tukey.  Resultados:  En el análisis químico se identificó principalmente pulegona (30,17 %) y mentona (16,55 %). Los halos de inhibición de Minthostachys mollis al 100 % a las 24, 48 y 72 horas frente a la Porphyromonas gingivalis, midieron: 10,2 mm, 9,8 mm y 9,6 mm, respectivamente; frente al Staphylococcus aureus, midieron: 10,4 mm, 9,7 mm y 9,4 mm, respectivamente; y, por último, frente a Candida albicans midieron: 9,8 mm, 8,9 mm y 8,5 mm, respectivamente. Todas las concentraciones de Minthostachys mollis presentaron un efecto antimicrobiano significativamente menor que el fluconazol y la doxiciclina (p &lt; 0,001).  Conclusiones:  El aceite esencial de Minthostachys mollis al 100 % presentó su mejor actividad inhibitoria frente al Staphylococcus aureus, la Porphyromonas gingivalis y la Candida albicans a las 24 horas. Sin embargo, este efecto antimicrobiano disminuye a medida que pasa el tiempo.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: Minthostachys mollis is an aromatic plant species growing in Latin America which produces essential oils with antimicrobial activity.  Objective:  Determine the activity of essential oil from Minthostachys mollis at various concentrations as compared with doxycycline and fluconazole against Porphyromonas gingivalis, Staphylococcus aureus and Candida albicans at 24, 48 and 72 hours.  Methods:  An in vitro experimental longitudinal study was conducted. Fifteen wells were prepared per subgroup to evaluate the inhibitory effect of all concentrations, for a sum total of 360 wells. Chemical components of the essential oil were identified by gas chromatography-mass spectrometry. The inhibitory effect was analyzed with the Kirby-Bauer diffusion method in Mueller-Hinton and Columbia agar. Statistical analysis was based on ANOVA and Tukey's test.  Results:  Chemical analysis mainly found pulegone (30.17%) and menthone (16.55%). The inhibition halos of 100% Minthostachys mollis at 24, 48 and 72 hours against Porphyromonas gingivalis measured 10.2 mm, 9.8 mm and 9.6 mm, respectively, against Staphylococcus aureus they measured 10.4 mm, 9.7 mm and 9.4 mm, respectively, and against Candida albicans they measured 9.8 mm, 8.9 mm and 8.5 mm, respectively. The antimicrobial effect of Minthostachys mollis at all concentrations was significantly lower than that of fluconazole and doxycycline (p &lt; 0.001).  Conclusions:  The essential oil from 100% Minthostachys mollis displayed its best inhibitory activity against Staphylococcus aureus, Porphyromonas gingivalis and Candida albicans at 24 hours. However, such antimicrobial effect decreases with the passing of time.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Minthostachys mollis]]></kwd>
<kwd lng="es"><![CDATA[Staphylococcus aureus]]></kwd>
<kwd lng="es"><![CDATA[Porphyromonas gingivalis]]></kwd>
<kwd lng="es"><![CDATA[Candida albicans]]></kwd>
<kwd lng="es"><![CDATA[fluconazol]]></kwd>
<kwd lng="es"><![CDATA[doxiciclina]]></kwd>
<kwd lng="es"><![CDATA[Kirby-Bauer]]></kwd>
<kwd lng="en"><![CDATA[Minthostachys mollis]]></kwd>
<kwd lng="en"><![CDATA[Staphylococcus aureus]]></kwd>
<kwd lng="en"><![CDATA[Porphyromonas gingivalis]]></kwd>
<kwd lng="en"><![CDATA[Candida albicans]]></kwd>
<kwd lng="en"><![CDATA[fluconazole, doxycycline, Kirby-Bauer]]></kwd>
</kwd-group>
</article-meta>
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