<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0864-0300</journal-id>
<journal-title><![CDATA[Revista Cubana de Investigaciones Biomédicas]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Invest Bioméd]]></abbrev-journal-title>
<issn>0864-0300</issn>
<publisher>
<publisher-name><![CDATA[ECIMED]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0864-03002021000400004</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Efecto antibacteriano del aceite esencial de Minthostachys mollis (Griseb) L. frente a Streptococcus mutans y Lactobacillus acidophilus]]></article-title>
<article-title xml:lang="en"><![CDATA[Antibacterial effect of Minthostachys mollis (Griseb) L. essential oil against Streptococcus mutans and Lactobacillus acidophilus]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez-Tito]]></surname>
<given-names><![CDATA[Marco Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cartagena-Cutipa]]></surname>
<given-names><![CDATA[Raúl]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Collantes-Díaz]]></surname>
<given-names><![CDATA[Ingrit]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Privada de Tacna Escuela Profesional de Odontología ]]></institution>
<addr-line><![CDATA[ Tacna]]></addr-line>
<country>Peru</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Privada de Tacna Escuela Profesional de Ingeniería Agroindustrial ]]></institution>
<addr-line><![CDATA[ Tacna]]></addr-line>
<country>Peru</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Nacional de Ingeniería Facultad de Ingeniería Química y Textil ]]></institution>
<addr-line><![CDATA[ Lima]]></addr-line>
<country>Peru</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>09</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>09</month>
<year>2021</year>
</pub-date>
<volume>40</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0864-03002021000400004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0864-03002021000400004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0864-03002021000400004&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: El uso de los aceites esenciales de plantas medicinales ha demostrado poseer propiedades antibacterianas frente a diversas especies bacterianas.  Objetivo: Identificar la composición química del aceite esencial de Minthostachys mollis (Griseb) L. y determinar su actividad antibacteriana frente a Streptococcus mutans y Lactobacillus acidophilus.  Métodos: Se realizó un estudio experimental in vitro. Se empleó el software EpiInfoTM para el cálculo de las repeticiones. Se obtuvo aceite esencial de M. mollis proveniente de la región altoandina del Perú. La composición química fue analizada por cromatografía de gases acoplada a espectrometría de masas. La actividad antibacteriana se evaluó por medio del método de difusión en disco, además, se identificó la concentración mínima inhibitoria y la concentración mínima bactericida.  Resultados: Los principales constituyentes del aceite esencial fueron mentona (32,9 %) y eucaliptol (28,06 %). El aceite esencial fue efectivo para inhibir el crecimiento de S. mutans y L. acidophilus, con halos de inhibición de 19,040 ± 0,883 mm y 18,008 ± 0,861 mm. La clorhexidina al 0,12 % fue más efectiva que el aceite esencial para inhibir el crecimiento de L. acidophilus (p &lt; 0,05). Una concentración de 1,6 % (v/v) del aceite esencial fue inhibitoria y bactericida frente a S. mutans; para L. acidophilus una concentración de 3,2 % (v/v) fue inhibitoria.  Conclusiones: Los principales constituyentes del aceite esencial de M. mollis fueron mentona y eucaliptol y demostró ser efectivo para inhibir el crecimiento de S. mutans y L. acidophilus.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  The use of essential oils from medicinal plants has been shown to possess antibacterial properties against various bacterial species.  Objective:  To identify the chemical composition of the essential oil of Minthostachys mollis (Griseb) L. and determine its antibacterial activity against Streptococcus mutans and Lactobacillus acidophilus.  Methods:  An experimental study was performed in vitro. EpiInfoTM software was used to calculate the repetitions. Essential oil of M. mollis was obtained from the high Andean region of Peru. The chemical composition was analyzed by gas chromatography coupled to mass spectrometry; antibacterial activity was evaluated by means of the disk diffusion method, in addition the minimum inhibitory concentration and the minimum bactericidal concentration were identified.  Results:  The main constituents of the essential oil were menthone (32.9 %) and eucalyptol (28.06 %). The essential oil was effective in inhibiting the growth of S. mutans and L. acidophilus, with inhibition halos of 19.040 ± 0.883 mm and 18.008 ± 0.861 mm. Chlorhexidine 0.12 % was more effective than essential oil in inhibiting the growth of L. acidophilus (p &lt; 0.05). A concentration of 1.6 % (v/v) of the essential oil was inhibitory and bactericidal against S. mutans; for L. acidophilus a concentration of 3.2 % (v/v) was inhibitory.  Conclusions:  The main constituents of the essential oil of M. mollis were menthone and eucalyptol and it was shown to be effective in inhibiting the growth of S. mutans and L. acidophilus.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[antibacterianos]]></kwd>
<kwd lng="es"><![CDATA[aceites vegetales]]></kwd>
<kwd lng="es"><![CDATA[Minthostachys mollis (Griseb) L.]]></kwd>
<kwd lng="es"><![CDATA[muña]]></kwd>
<kwd lng="es"><![CDATA[Streptococcus mutans]]></kwd>
<kwd lng="es"><![CDATA[Lactobacillus acidophilus]]></kwd>
<kwd lng="en"><![CDATA[anti-bacterial agents]]></kwd>
<kwd lng="en"><![CDATA[plant oils]]></kwd>
<kwd lng="en"><![CDATA[Minthostachys mollis (Griseb) L.]]></kwd>
<kwd lng="en"><![CDATA[muña]]></kwd>
<kwd lng="en"><![CDATA[Streptococcus mutans]]></kwd>
<kwd lng="en"><![CDATA[Lactobacillus acidophilus]]></kwd>
</kwd-group>
</article-meta>
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