<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0864-2125</journal-id>
<journal-title><![CDATA[Revista Cubana de Medicina General Integral]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Med Gen Integr]]></abbrev-journal-title>
<issn>0864-2125</issn>
<publisher>
<publisher-name><![CDATA[ECIMED]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0864-21252019000200004</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Impacto de la consanguinidad en la descendencia de matrimonios consanguíneos]]></article-title>
<article-title xml:lang="en"><![CDATA[Impact of Consanguinity in the Offspring of Consanguineous Marriages]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mesa Trujillo]]></surname>
<given-names><![CDATA[Daisy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lantigua Cruz]]></surname>
<given-names><![CDATA[Araceli]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Sectorial Municipal de Salud  ]]></institution>
<addr-line><![CDATA[Pinar del Río ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro Nacional de Genética Médica  ]]></institution>
<addr-line><![CDATA[Ciudad de La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<volume>35</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0864-21252019000200004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0864-21252019000200004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0864-21252019000200004&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La consanguinidad continúa siendo un fenómeno universal, hoy día los matrimonios consanguíneos y su descendencia suponen aproximadamente el 10,4 % de la población mundial; sus descendientes tienen una elevada probabilidad de padecer enfermedades mendelianas recesivas, así como enfermedades complejas de naturaleza multifactorial.  Objetivos: Determinar el coeficiente de endogamia de la región y las principales afectaciones encontradas en la descendencia de matrimonios consanguíneos.  Métodos: Se realizó una investigación descriptiva, aplicada y retrospectiva de corte transversal sobre coeficiente de endogamia en el Consejo Popular Paso Quemado, municipio Los Palacios, Pinar del Río, en el período comprendido entre mayo 2016 y febrero 2017.  Resultados: Fueron identificados 11 matrimonios consanguíneos (1,96 %), mayormente en área rural y entre primos hermanos. El coeficiente de endogamia medio fue 0,00115. Después de la década del 70 no se efectuaron matrimonios consanguíneos. Afectaciones como mortalidad infantil, enfermedades monogénicas raras, malformaciones congénitas, discapacidad intelectual leve y enfermedades comunes aparecieron con mayor frecuencia en la descendencia de primos hermanos.  Conclusiones: En correspondencia con la apertura de nuevas oportunidades sociales, económicas y educativas en la región la consanguinidad no constituye hoy en día un problema de salud, no obstante 52,5 % de la descendencia en consanguíneos resultó afectada, mayormente por enfermedades complejas. El estudio sienta las bases para establecer una estrategia de educación y promoción de salud a nivel comunitario.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Consanguinity continues to be a universal phenomenon. Nowadays, consanguineous marriages and their descendants are estimated at 10,4% of the world population; their descendants have a high probability of suffering recessive Mendelian diseases, as well as complex diseases of multifactorial nature.  Objectives:  To determine the inbreeding coefficient of the region and the main affectations found in offspring of consanguineous marriages.  Methods:  A descriptive, applied and retrospective cross-sectional research on the inbreeding coefficient was conducted at Paso Quemado Popular Council, Los Palacios Municipality, Pinar del Río, from May 2016 to February 2017.  Results:  We identified 11 consanguineous marriages (1.96%), mostly in rural areas and among first cousins. The average inbreeding coefficient was 0.00115. After the 70's, there was no occurrence of consanguineous marriages. Affectations such as infant mortality, rare monogenic diseases, congenital malformations, mild intellectual disability and common diseases appeared more frequently in the offspring of first cousins.  Conclusions:  In correspondence with the opening of new social, economic and educational opportunities in the region, consanguinity does not constitute a health problem nowadays; however, mostly complex diseases affected 52.5% of offspring in consanguineous couples. The study lays the foundations to establish a health education and promotion strategy at the community level.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Consanguinidad]]></kwd>
<kwd lng="es"><![CDATA[coeficiente de endogamia]]></kwd>
<kwd lng="es"><![CDATA[homocigocidad]]></kwd>
<kwd lng="en"><![CDATA[Consanguinity]]></kwd>
<kwd lng="en"><![CDATA[inbreeding coefficient]]></kwd>
<kwd lng="en"><![CDATA[homozygosity]]></kwd>
</kwd-group>
</article-meta>
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