<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0864-2125</journal-id>
<journal-title><![CDATA[Revista Cubana de Medicina General Integral]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Med Gen Integr]]></abbrev-journal-title>
<issn>0864-2125</issn>
<publisher>
<publisher-name><![CDATA[ECIMED]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0864-21252019000400001</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Agregación familiar para cáncer de cuello uterino]]></article-title>
<article-title xml:lang="en"><![CDATA[Family aggregation for cervical cancer]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Pérez]]></surname>
<given-names><![CDATA[Alvaro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gonzáles Moreno]]></surname>
<given-names><![CDATA[Ivian Zoila]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Larralde]]></surname>
<given-names><![CDATA[Raúl Lázaro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Terrero Quiala]]></surname>
<given-names><![CDATA[Lisbet]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Holguín Facultad de Ciencias Médicas "Mariana Grajales Coello ]]></institution>
<addr-line><![CDATA[Holguín ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas de Holguín Centro Oncológico de Holguín. Hospital General Docente "Vladimir Ilich Lenin" ]]></institution>
<addr-line><![CDATA[Holguín ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2019</year>
</pub-date>
<volume>35</volume>
<numero>4</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0864-21252019000400001&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0864-21252019000400001&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0864-21252019000400001&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  El cáncer de cuello uterino es una neoplasia maligna originada en el cuello del útero, principalmente en la zona de transformación donde confluyen células escamosas y glandulares.  Objetivo:  Determinar la existencia de agregación familiar para cáncer de cuello uterino.  Métodos:  Se realizó un estudio analítico transversal de casos y controles (estudio de agregación familiar) en pacientes atendidas en consulta de Oncología Ginecológica. Hospital General Universitario "Vladimir Ilich Lenin", desde septiembre de 2017 a febrero de 2018. La muestra quedó conformada por 60 mujeres con el diagnóstico histológico de cáncer de cuello uterino (casos) y por 60 mujeres sin diagnóstico de enfermedad oncológica (controles). Ambos grupos fueron tomados de las áreas de salud pertenecientes al municipio Holguín y pareados por edad.  Resultados:  En el grupo casos existió una mayor frecuencia en el antecedente familiar para cáncer de cuello uterino, siendo más elevada para los familiares de 1er grado (31 familiares, 41,3 %). El antecedente de infecciones vaginales se presentó como el factor de riesgo de mayor frecuencia, con 36,7 % en el grupo casos y 37,1 % en el grupo controles. Se determinó un riesgo aproximadamente 4 veces mayor de padecer cáncer de cuello uterino en aquellos individuos con historia familiar positiva de 1er grado, mientras que las mujeres con antecedentes de infecciones vaginales tenían 4,8 más riesgo de padecer cáncer de cuello uterino.  Conclusiones:  Mediante esta investigación se determinó que existe agregación familiar para cáncer de cuello uterino, mostraron un riesgo mayor de enfermar las pacientes con historia familiar positiva para la enfermedad y antecedentes de infecciones vaginales.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Cervical cancer is a malignant neoplasm originating in the cervix uteri, mainly in the transformation area where squamous and glandular cells converge.  Objective:  Determine the existence of family aggregation for cervical cancer.  Methods:  An analytical cross-sectional case-control family aggregation study was conducted of patients attending the Gynecologic Oncology Service at Vladimir Ilich Lenin General University Hospital from September 2017 to February 2018. The sample was 60 women with a histological diagnosis of cervical cancer (cases) and 60 women without an oncological diagnosis (controls). Both groups were recruited from the health areas in the municipality of Holguín and paired by age.  Results:  In the case group there was a greater frequency of family antecedents of cervical cancer, which was higher for first-degree relatives (31 relatives, 41.3%). A history of vaginal infection was the most common risk factor with 36.7% in the case group and 37.1% in the control group. It was determined that the risk for cervical cancer is approximately fourfold greater among individuals with a positive first-degree family history, whereas women with antecedents of vaginal infection were at 4.8 times greater risk for cervical cancer.  Conclusions:  The study determined the existence of family aggregation for cervical cancer, with a greater risk for the disease among women with a positive family history and antecedents of vaginal infection.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Cuello uterino]]></kwd>
<kwd lng="es"><![CDATA[cáncer de cuello uterino]]></kwd>
<kwd lng="es"><![CDATA[agregación familiar]]></kwd>
<kwd lng="en"><![CDATA[cervix]]></kwd>
<kwd lng="en"><![CDATA[cervical cancer]]></kwd>
<kwd lng="en"><![CDATA[family aggregation]]></kwd>
</kwd-group>
</article-meta>
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