<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>0864-3466</journal-id>
<journal-title><![CDATA[Revista Cubana de Salud Pública]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Salud Pública]]></abbrev-journal-title>
<issn>0864-3466</issn>
<publisher>
<publisher-name><![CDATA[Editorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S0864-34662018000100086</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Reacciones adversas por antipalúdicos en hospitales centrales y provinciales de Angola]]></article-title>
<article-title xml:lang="en"><![CDATA[Adverse reactions due to antimalarials in central and provincial hospitals in Angola]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[João Fernandes]]></surname>
<given-names><![CDATA[Mateus Sebastião]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castañeda Abascal]]></surname>
<given-names><![CDATA[Ileana Elena]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lara Fernández]]></surname>
<given-names><![CDATA[Héctor Lázaro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Furones Mourelle]]></surname>
<given-names><![CDATA[Juan Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Ministerio de Salud Dirección Nacional de Medicamentos y Equipos Médicos ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Angola</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Escuela Nacional de Salud Pública  ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Centro Nacional Coordinador de Ensayos Clínicos  ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>03</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>03</month>
<year>2018</year>
</pub-date>
<volume>44</volume>
<numero>1</numero>
<fpage>86</fpage>
<lpage>99</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S0864-34662018000100086&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S0864-34662018000100086&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S0864-34662018000100086&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  El paludismo es la primera causa de morbilidad y mortalidad en Angola. Las particularidades de las reacciones adversas a antipalúdicos no están bien establecidas en pacientes hospitalizados.  Objetivo:  Caracterizar las reacciones adversas a medicamentos antipalúdicos.  Método:  Estudio de farmacovigilancia activa de serie de casos. El universo fueron 2 634 pacientes ingresados con paludismo confirmado en los hospitales centrales y provinciales de Angola durante el primer semestre de 2015. Médicos entrenados realizaron pesquisa diaria a través de interrogatorios farmacológicos, pases de visita y revisión de historias clínicas.  Resultados:  Hubo una tasa de 7,5 reacciones adversas por cada 100 pacientes internados. El 77,8 % eran adultos y el 15,7 % niños. Hubo predominio del sexo femenino en los niños y adultos (51,6 % y 52,6 %, respectivamente). Las reacciones más notificadas fueron las náuseas y vómitos (14,3 %), el dolor abdominal (13,4 %) y la erupción cutánea y los temblores, ambos con el 11,7 %. La quinina endovenosa fue el antipalúdico de mayores reportes de reacciones adversas (29,0 %). Además, las quininas (oral y endovenosa) provocaron el 41,1 % del total de reacciones adversas encontradas. Predominaron las reacciones adversas leves (73,2 %), las probables (47,6 %) y las de aparición frecuentes (69,7 %).  Conclusiones:  Existen reacciones adversas a los tratamientos antipalúdicos impuestos en los hospitales centrales y provinciales de Angola. Es importante la vigilancia activa en la identificación y el reporte de los efectos adversos por fármacos en los escenarios con sistema de farmacovigilancia que no alcanzan una implementación efectiva.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Malaria is the main cause of morbidity and mortality in Angola. Characteristics of adverse reactions due to antimalarials are not well established in hospitalized patients.  Objective:  Characterization of adverse reactions to antimalarial drugs.  Method:  An active pharmacovigilance study was carried out in a series of cases. There was a total of 2 634 patients admitted in central and provincial hospitals of Angola with confirmed malaria during the first semester of 2015. Trained doctors conducted daily screenings through pharmacological questionnaires, visits to the patients and reviews of medical records.  Results:  It was found that there was a rate of 7.5 adverse reactions per 100 hospitalized patients. 77.8 % were adults and 15.7 % were children. There was a predominance of females in children and adults (51.6 % and 52.6 %, respectively). The most commonly reported reactions were nausea and vomiting (14.3 %), abdominal pain (13.4 %) and rash and tremors both with 11.7 %. Intravenous quinine was the antimalarial with the highest number of reports of adverse reactions (29.0 %). In addition, oral and intravenous quinine caused 41.1 % of the total number of ADRs found. Mild adverse reactions (73.2 %), probable adverse reactions (47.6 %) and frequent adverse reactions (69.7 %) were predominant.  Conclusions:  Data provided by the study show the existence of adverse reactions to antimalarial treatments in central and provincial hospitals in Angola. It is highlighted the importance of an active surveillance in the identification and reporting of adverse effects due to drugs in scenarios with a pharmacovigilance system that does not reach an effective implementation.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Reacción adversa a medicamentos]]></kwd>
<kwd lng="es"><![CDATA[monitorización intensiva]]></kwd>
<kwd lng="es"><![CDATA[antipalúdicos]]></kwd>
<kwd lng="es"><![CDATA[farmacovigilancia.]]></kwd>
<kwd lng="en"><![CDATA[Adverse reaction to drugs]]></kwd>
<kwd lng="en"><![CDATA[intensive monitoring]]></kwd>
<kwd lng="en"><![CDATA[antimalarials]]></kwd>
<kwd lng="en"><![CDATA[pharmacovigilance]]></kwd>
</kwd-group>
</article-meta>
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