<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1025-0255</journal-id>
<journal-title><![CDATA[Revista Archivo Médico de Camagüey]]></journal-title>
<abbrev-journal-title><![CDATA[AMC]]></abbrev-journal-title>
<issn>1025-0255</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de Camagüey]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1025-02552020000400012</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Enfermedad de Crohn perianal fistulizante]]></article-title>
<article-title xml:lang="en"><![CDATA[Fistulizing perianal Crohn's disease]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cervantes-Peláez]]></surname>
<given-names><![CDATA[Dayan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas-Peláez]]></surname>
<given-names><![CDATA[Yosvany]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Gutiérrez]]></surname>
<given-names><![CDATA[Damary]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Quiróz Sánchez]]></surname>
<given-names><![CDATA[Evaristo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gaspar-Sánchez]]></surname>
<given-names><![CDATA[Joaquín]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Camagüey Hospital Universitario Manuel Ascunce Domenech Servicio de Coloproctología]]></institution>
<addr-line><![CDATA[Camagüey ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas de Camagüey Policlínico Docente José Martí Servicio de Gastroenterología]]></institution>
<addr-line><![CDATA[Camagüey ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Ciencias Médicas de Camagüey Hospital Universitario Manuel Ascunce Domenech Servicio de Cirugía]]></institution>
<addr-line><![CDATA[Camagüey ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad de Ciencias Médicas Victoria de Girón Centro Nacional Coordinador de Ensayos Clínicos ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<volume>24</volume>
<numero>4</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1025-02552020000400012&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1025-02552020000400012&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1025-02552020000400012&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Fundamento: la enfermedad de Crohn se caracteriza por inflamación granulomatosa segmentaria del tracto intestinal y suele afectar los tejidos cutáneos. Su desarrollo incluye la compleja interacción entre la predisposición genética, la exposición al medio ambiente, la disfunción de la barrera epitelial y la respuesta inmunitaria anormal a bacterias patógenas y comensales. Las lesiones específicas de la enfermedad son manifestaciones extraintestinales, las más comunes: aftas orales y las fístulas perianales.  Objetivo:  exponer un caso con enfermedad de Crohn perianal fistulizante.  Presentación del caso:  paciente de 42 años masculino, blanco con antecedentes de haber sido atendido desde el año 2006 por estomatitis aftosa recurrente. Llega al Hospital Universitario Manuel Ascunce Domenech por primera vez en el 2013, donde fue valorado y seguido por el servicio de Coloproctología.  Conclusiones:  se realizó colonoscopia evolutiva y toma de biopsia, se sospechó por el cuadro en la enfermedad de Crohn con localización perianal.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Background:  Crohn's disease is characterized by segmental granulomatous inflammation of the intestinal tract and usually affects the cutaneous tissues. Its development includes the complex interaction between genetic predisposition, exposure to the environment, dysfunction of the epithelial barrier and the abnormal immune response to pathogenic and commensal bacteria. The specific lesions of the disease are extra-intestinal manifestations, the most common: oral aphthae and perianal fistulas.  Objective:  to report a case with fistulizing perianal Crohn's disease.  Case report:  42-year-old male patient, white; with a history of having been treated since 2006 for recurrent aphthous stomatitis. He arrives at the Manuel Ascunce Domenech University Hospital for the first time in 2013, where he was evaluated and followed by the Coloproctology service.  Conclusions:  an evolutionary colonoscopy and biopsy was performed, it was suspected by the symptoms in Crohn's disease with perianal localization.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[ENFERMEDAD DE CROHN]]></kwd>
<kwd lng="es"><![CDATA[FÍSTULA RECTAL]]></kwd>
<kwd lng="es"><![CDATA[ENFERMEDADES INFLAMATORIAS DEL INTESTINO/etiología]]></kwd>
<kwd lng="es"><![CDATA[COLONOSCOPÍA]]></kwd>
<kwd lng="es"><![CDATA[INFORMES DE CASOS]]></kwd>
<kwd lng="en"><![CDATA[CROHN DISEASE]]></kwd>
<kwd lng="en"><![CDATA[RECTAL FISTULA]]></kwd>
<kwd lng="en"><![CDATA[INFLAMMATORY BOWEL DISEASES/etiology]]></kwd>
<kwd lng="en"><![CDATA[COLONOSCOPY]]></kwd>
<kwd lng="en"><![CDATA[CASE REPORTS]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dutta]]></surname>
<given-names><![CDATA[AK]]></given-names>
</name>
<name>
<surname><![CDATA[Chacko]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Influence of environmental factors on the onset and course of inflammatory bowel disease]]></article-title>
<source><![CDATA[World J Gastroenterol]]></source>
<year>2016</year>
<volume>22</volume>
<page-range>1088-100</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fumis]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Bidabehere]]></surname>
<given-names><![CDATA[MB]]></given-names>
</name>
<name>
<surname><![CDATA[Gubiani]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
<name>
<surname><![CDATA[Boldrini]]></surname>
<given-names><![CDATA[MP]]></given-names>
</name>
<name>
<surname><![CDATA[Pinardi]]></surname>
<given-names><![CDATA[BA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pioderma vegetante]]></article-title>
<source><![CDATA[Dermatol Rev Mex]]></source>
<year>2018</year>
<volume>62</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>62-6</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sarmiento Quintero]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluación del sangrado digestivo bajo en la urgencia pediátrica]]></article-title>
<source><![CDATA[Rev Colomb Gastroenterol]]></source>
<year>2018</year>
<volume>33</volume>
<page-range>74-9</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[García Duperly]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Enfermedad de Crohn perianal fistulizante compleja: ¿Antibióticos, setones o terapia biológica?]]></article-title>
<source><![CDATA[Rev Colomb Gastroenterol]]></source>
<year>2018</year>
<volume>33</volume>
<page-range>97-100</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Irvine]]></surname>
<given-names><![CDATA[EJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Usual therapy improves perianal Crohn ´s disease as measured by a new disease activity index McMaster IBD Study Group]]></article-title>
<source><![CDATA[J Clin Gastroenterol]]></source>
<year>1995</year>
<volume>20</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>27-32</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sandborn]]></surname>
<given-names><![CDATA[WJ]]></given-names>
</name>
<name>
<surname><![CDATA[Fazio]]></surname>
<given-names><![CDATA[VW]]></given-names>
</name>
<name>
<surname><![CDATA[Feagan]]></surname>
<given-names><![CDATA[BG]]></given-names>
</name>
<name>
<surname><![CDATA[Hanauer]]></surname>
<given-names><![CDATA[SB]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[AGA technical review on perianal Crohn's disease]]></article-title>
<collab>American Gastroenterological Association Clinical Practice Committee</collab>
<source><![CDATA[Gastroenterology]]></source>
<year>2003</year>
<volume>125</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1508-30</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kay]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Eng]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Wyllie]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Colonic polyps and polyposis syndromes in pediatric patients]]></article-title>
<source><![CDATA[Curr Opin Pediatr]]></source>
<year>2015</year>
<volume>27</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>634-41</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Reyes]]></surname>
<given-names><![CDATA[GA]]></given-names>
</name>
<name>
<surname><![CDATA[Gil]]></surname>
<given-names><![CDATA[FL]]></given-names>
</name>
<name>
<surname><![CDATA[Carvajal]]></surname>
<given-names><![CDATA[GD]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez]]></surname>
<given-names><![CDATA[CB]]></given-names>
</name>
<name>
<surname><![CDATA[Aponte]]></surname>
<given-names><![CDATA[DM]]></given-names>
</name>
<name>
<surname><![CDATA[González]]></surname>
<given-names><![CDATA[CA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Enfermedad inflamatoria intestinal: características de fenotipo y tratamiento en un hospital universitario de Bogotá, Colombia]]></article-title>
<source><![CDATA[Rev Col Gastroenterol]]></source>
<year>2018</year>
<volume>33</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>117-26</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mauryane Lopes]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Bezerra de Moura]]></surname>
<given-names><![CDATA[LN]]></given-names>
</name>
<name>
<surname><![CDATA[Silva Machado]]></surname>
<given-names><![CDATA[R da]]></given-names>
</name>
<name>
<surname><![CDATA[Freitas da Silva]]></surname>
<given-names><![CDATA[GR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Quality of life of patients with Crohn's disease]]></article-title>
<source><![CDATA[Enferm Global]]></source>
<year>2017</year>
<volume>47</volume>
</nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[López-Cepeda]]></surname>
<given-names><![CDATA[LD]]></given-names>
</name>
<name>
<surname><![CDATA[Hernández-Barrios]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Cortés-Esparza]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
<name>
<surname><![CDATA[Navarrete-Franco]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Ramos Garibay]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[González-González]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Úlceras genitales y perianales como manifestación de enfermedad de Crohn]]></article-title>
<source><![CDATA[Dermatol Rev Mex]]></source>
<year>2018</year>
<volume>62</volume>
<numero>3</numero>
<issue>3</issue>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Martín Varas]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Heras]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Saiz]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Coloma]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Calle]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Callejas]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Vasculitis asociada a anticuerpo anticitoplasma de neutrófilo en paciente con enfermedad de Crohn en tratamiento con adalimumab]]></article-title>
<source><![CDATA[Nefrología]]></source>
<year>2017</year>
<volume>37</volume>
<numero>5</numero>
<issue>5</issue>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Guimarães de Carvalho]]></surname>
<given-names><![CDATA[AC]]></given-names>
</name>
<name>
<surname><![CDATA[Silva Fonseca]]></surname>
<given-names><![CDATA[AM da]]></given-names>
</name>
<name>
<surname><![CDATA[Ribeiro Moreira da Costa]]></surname>
<given-names><![CDATA[EM]]></given-names>
</name>
<name>
<surname><![CDATA[Jesus Costa Lira]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
<name>
<surname><![CDATA[Gomes Grácio dos Reis]]></surname>
<given-names><![CDATA[ACC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Doença inflamatória intestinal com eritema nodoso como manifestação inicial-dois casos clínicos]]></article-title>
<source><![CDATA[Sci Med]]></source>
<year>2018</year>
<volume>28</volume>
<numero>3</numero>
<issue>3</issue>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
