<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1025-0255</journal-id>
<journal-title><![CDATA[Revista Archivo Médico de Camagüey]]></journal-title>
<abbrev-journal-title><![CDATA[AMC]]></abbrev-journal-title>
<issn>1025-0255</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de Camagüey]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1025-02552021000500011</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Síndrome de Alagille: una causa de colestasis del lactante a tener en cuenta]]></article-title>
<article-title xml:lang="en"><![CDATA[Alagille syndrome: cause of the child's cholestasis to have in account]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carmenates-Álvarez]]></surname>
<given-names><![CDATA[Bárbara Maitee]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Reyes-Escobar]]></surname>
<given-names><![CDATA[Ana Dianelis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peña-Borroto]]></surname>
<given-names><![CDATA[Yamilka Joamis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas-Peláez]]></surname>
<given-names><![CDATA[Yosvany]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Camagüey. Hospital Pediátrico Universitario Eduardo Agramonte Piña Departamento de Gastroenterología]]></institution>
<addr-line><![CDATA[Camagüey ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas de Camagüey. Hospital Pediátrico Provincial Eduardo Agramonte Piña. Servicio de Imagenología.]]></institution>
<addr-line><![CDATA[Camagüey ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Ciencias Médicas de Camagüey. Policlínico Docente José Martí Pérez. Departamento de Gastroenterología.]]></institution>
<addr-line><![CDATA[Camagüey ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2021</year>
</pub-date>
<volume>25</volume>
<numero>5</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1025-02552021000500011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1025-02552021000500011&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1025-02552021000500011&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Fundamento: el síndrome de Alagille, también conocido como displasia arteriohepática, es una enfermedad poco frecuente en lactantes. Es una enfermedad hereditaria, de transmisión autosómica dominante con penetración incompleta. Clínicamente se determina por cinco características principales: colestasis, estenosis pulmonar congénita, vértebras en forma de mariposa, alteraciones oculares y unas facciones singulares.  Objetivo: presentar el caso de un lactante con síndrome de Alagille como causa de colestasis crónica.  Presentación del caso: paciente de raza blanca, femenina de dos meses de edad, procedente de la provincia Camagüey, que ingresó en Hospital Pediátrico Eduardo Agramonte Piña en octubre 2018, con antecedentes de bajo peso al nacer, que presentó íctero, coluria, acolia, fenotipo peculiar (cara triangular, hipertelorismo, frente ancha, ojos profundos, mentón puntiagudo) y ganancia insuficiente de peso. Por esta sintomatología es atendida por la especialidad de Gastroenterología.  Conclusiones:  se debe sospechar el síndrome de Alagille en lactantes con síntomas y signos de colestasis crónica. Su seguimiento es ambulatorio, en consulta de hepatopatía crónica.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Background:  Alagille syndrome, also known as arterio-hepatic dysplasia, is a rare disease in infants. It is a hereditary disease, of autosomal dominant transmission with incomplete penetration. Clinically, it is determined by five main characteristics: cholestasis, congenital pulmonary stenosis, butterfly-shaped vertebrae, ocular alterations, and unique features.  Objective:  to present a case of an infant with Alagille syndrome as cause of chronic cholestasis.  Case report:  a two month old female white patient from the Camagüey province, who was admitted to the Eduardo Agramonte Piña Pediatric Hospital in October 2018, with a history of low birth weight, who presented with icterus, coluria, acholia, peculiar phenotype (triangular face, hypertelorism, wide forehead, deep eyes, pointed chin) and insufficient weight gain. For these symptoms she is attended by the specialty of Gastroenterology.  Conclusions:  the Alagille syndrome must be suspected in infants with symptoms and signs of chronic cholestasis. Their follow-up is ambulatory, in chronic hepatopaty's consultation.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[SÍNDROME DE ALAGILLE]]></kwd>
<kwd lng="es"><![CDATA[COLESTASIS]]></kwd>
<kwd lng="es"><![CDATA[LACTANTE]]></kwd>
<kwd lng="es"><![CDATA[INFORMES DE CASOS]]></kwd>
<kwd lng="es"><![CDATA[HEPATOPATÍAS]]></kwd>
<kwd lng="en"><![CDATA[ALAGILLE SYNDROME]]></kwd>
<kwd lng="en"><![CDATA[CHOLESTASIS]]></kwd>
<kwd lng="en"><![CDATA[INFANT]]></kwd>
<kwd lng="en"><![CDATA[CASE REPORTS]]></kwd>
<kwd lng="en"><![CDATA[LIVER DISEASES]]></kwd>
</kwd-group>
</article-meta>
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