<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1025-0255</journal-id>
<journal-title><![CDATA[Revista Archivo Médico de Camagüey]]></journal-title>
<abbrev-journal-title><![CDATA[Arch méd Camagüey]]></abbrev-journal-title>
<issn>1025-0255</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de Camagüey]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1025-02552023000100055</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Caracterización morfométrica nuclear de la epidermis sana en pacientes de diferentes edades y sexo]]></article-title>
<article-title xml:lang="en"><![CDATA[Nuclear Morphometric characterization of the healthy epidermis in patients with different ages and sex]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peña-Marrero]]></surname>
<given-names><![CDATA[Doralny]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez-Anta]]></surname>
<given-names><![CDATA[Alejandro de Jesús]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz-Rojas]]></surname>
<given-names><![CDATA[Pedro Augusto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Macareño-Ávila]]></surname>
<given-names><![CDATA[Dunia Yailin]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Silva-Jardínez]]></surname>
<given-names><![CDATA[Liúdisis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mármol-Caballero]]></surname>
<given-names><![CDATA[Leticia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas Facultad de Ciencias Médicas Mariana Grajales Coello Departamento de Ciencias Básicas Biomédicas]]></institution>
<addr-line><![CDATA[Holguín ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>27</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1025-02552023000100055&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1025-02552023000100055&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1025-02552023000100055&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción : La piel es un órgano complejo altamente vulnerable al envejecimiento, fenómeno que biológicamente provoca cambios a nivel tisular y celular. De manera usual los elementos histológicos que la caracterizan se describen con un enfoque cualitativo, sin tener en cuenta la edad, sin embargo, desde el punto de vista cuantitativo, aspecto este que lo posibilita la morfometría no ha sido abordado en todas sus potencialidades.  Objetivo : Caracterizar el comportamiento de indicadores morfométricos como perímetro, área, volumen nuclear en las células de la capa espinosa de la epidermis sana, según edad y sexo.  Métodos : Se realizó un estudio de serie de casos con 12 pacientes con diagnóstico histopatológico de carcinoma basocelular atendidos en Centro Oncológico del Hospital Provincial Universitario Vladimir Ilich Lenin de Holguín, en el año 2019 y a los cuales se les extirpó el tumor mediante una biopsia escisional que incluía la lesión y un borde amplio de piel sana. Se emplearon métodos teóricos y empíricos, estos últimos basados en técnicas morfométricas, luego se realizó análisis estadísticos de los datos obtenidos y se reflejaron en tablas.  Resultados : A medida que avanza la edad el perímetro, el área y el volumen nuclear disminuyen en ambos sexos.  Conclusiones : Tanto el perímetro, como el área y el volumen nuclear disminuyen en las células de la capa espinosa de la epidermis sana en ambos sexos a medida que avanza la edad, lo que traduce disminución del tamaño nuclear.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: The skin is a complex organ highly vulnerable to aging, a phenomenon that biologically causes changes at the tissue and cellular level. Usually the histological elements that characterize it are described with a qualitative approach, without taken age into account, however from the quantitative point of view, this aspect that morphometry makes possible has not been addressed in all its potentialities.  Objective: To characterize the behavior of morphometric indicators such as perimeter, area, nuclear volume in the cells of the spinous layer of the healthy epidermis, according to age and sex.  Methods: A case series study was carried out with 12 patients diagnosed with histopathology of basal cell carcinoma treated at the Oncology Center of the Provincial University Hospital Vladimir Ilich Lenin of Holguin, in the year 2019 and to which the tumor was removed by means of an excisional biopsy that included the lesion and a broad border of healthy skin. Theoretical and empirical methods were used, the latter based on techniques morphometric, then statistical analysis of the data obtained was performed and were reflected in tables.  Results: As age advances the nuclear perimeter, area, and volume decreased in both sexes.  Conclusions: Both the perimeter, the area and the nuclear volume decrease in the cell of the spinous layer of the healthy epidermis in both sexes as age advances, which translates into a decrease in nuclear size.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[EPIDERMIS]]></kwd>
<kwd lng="es"><![CDATA[PIEL]]></kwd>
<kwd lng="es"><![CDATA[ENVEJECIMIENTO DE LA PIEL]]></kwd>
<kwd lng="es"><![CDATA[CARCINOMA BASOCELULAR/patología]]></kwd>
<kwd lng="es"><![CDATA[CARCINOMA BASOCELULAR/terapia]]></kwd>
<kwd lng="en"><![CDATA[EPIDERMIS]]></kwd>
<kwd lng="en"><![CDATA[SKIN]]></kwd>
<kwd lng="en"><![CDATA[SKIN AGING]]></kwd>
<kwd lng="en"><![CDATA[CARCINOMA, BASAL CELL/pathology]]></kwd>
<kwd lng="en"><![CDATA[CARCINOMA, BASAL CELL/therapy]]></kwd>
</kwd-group>
</article-meta>
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<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cantwell]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Nurse]]></surname>
<given-names><![CDATA[P.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Unravelling nuclear size control.]]></article-title>
<source><![CDATA[Current Genetics]]></source>
<year>2019</year>
<volume>65</volume>
<page-range>1281-5</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
