<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1027-2852</journal-id>
<journal-title><![CDATA[Biotecnología Aplicada]]></journal-title>
<abbrev-journal-title><![CDATA[Biotecnol Apl]]></abbrev-journal-title>
<issn>1027-2852</issn>
<publisher>
<publisher-name><![CDATA[Editorial Elfos Scientiae]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1027-28522010000200012</article-id>
<title-group>
<article-title xml:lang="en"><![CDATA[Could it be possible that the Anti-vector brigades, in charge of controlling Aedes aegypti mosquito infestation levels play a role in reducing the rate of amputations caused by diabetic foot ulcers in Cuba?]]></article-title>
<article-title xml:lang="es"><![CDATA[¿Podrían las Brigadas de lucha contra el mosquito Aedes aegypti ayudar a reducir los índices de amputación por úlceras de pie diabético en Cuba?]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Raíces]]></surname>
<given-names><![CDATA[Manuel]]></given-names>
</name>
<xref ref-type="aff" rid="A01"/>
</contrib>
</contrib-group>
<aff id="A01">
<institution><![CDATA[,Centro de Ingeniería Genética y Biotecnología  ]]></institution>
<addr-line><![CDATA[Ciudad de La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2010</year>
</pub-date>
<volume>27</volume>
<numero>2</numero>
<fpage>173</fpage>
<lpage>174</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1027-28522010000200012&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1027-28522010000200012&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1027-28522010000200012&amp;lng=en&amp;nrm=iso"></self-uri></article-meta>
</front><body><![CDATA[ <DIV class="Sect"   >        <P align="right"   ><font size="2" color="#000000" face="Verdana, Arial, Helvetica, sans-serif"><b>FOCUS</b></font></P >       <P align="right"   >&nbsp;</P >   <FONT size="+1" color="#000000">        <P   ><font size="2" face="Verdana, Arial, Helvetica, sans-serif"><B><font size="4">Could      it be possible that the Anti-vector brigades, in charge of controlling <i>Aedes      aegypti</i> mosquito infestation levels play a role in reducing the rate of      amputations caused by diabetic foot ulcers in Cuba?</font></b></font></P >       <P   >&nbsp;</P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="3"><b>&iquest;Podr&iacute;an      las Brigadas de lucha contra el mosquito <i>Aedes aegypti</i> ayudar a reducir      los &iacute;ndices de amputaci&oacute;n por &uacute;lceras de pie diab&eacute;tico      en Cuba?</b></font></P >       <P   >&nbsp;</P >       <P   >&nbsp;</P >   <FONT size="+1">        <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2"><b>Manuel Ra&iacute;ces</b>      </font></P >   <FONT size="+1">        <P   ><font size="2" face="Verdana, Arial, Helvetica, sans-serif">Centro de Ingenier&iacute;a      Gen&eacute;tica y Biotecnolog&iacute;a, CIGB Ave. 31 entre 158 y 190, Cubanac&aacute;n,      Playa, AP 6162, CP 10 600, Ciudad de La Habana, Cuba</font></P >   </font></font></font>   <hr>   <FONT size="+1" color="#000000"><FONT size="+1"><FONT size="+1"><FONT size="+1"><FONT color="#0000FF"><FONT color="#000000">        ]]></body>
<body><![CDATA[<P   >&nbsp;</P >       <P   >&nbsp;</P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">Quite recently a      group of the staff at the Center for Genetic Engineering and Biotechnology      (CIGB abreviation of Centro de Ingenier&iacute;a Gen&eacute;tica y Biotecnolog&iacute;a),      I included, agreed on responding to a call from our political and trade union      organizations to support the Cuban Ministry of Health campaign to control      mosquito infestation levels in our capital city (1). This call was due to      the need to diminish <I>Aedes aegypti </I>infestation in several Havana municipalities.      </font></P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">Among the CIGB employees,      willing to support the mosquito fight crusade, there were some people engaged      in the campaign for extending the use of Heberprot-P, which is a unique Cuban      biotech drug able to heal wounds in diabetic foot ulcers (DFU), as part of      a national program. The desicion to spend time in controlling mosquitoes for      a limited period of time meant that we have to follow up our Heberprot P duties      at extra hours. </font></P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">Once at the polyclinic,      located on 25 st. between 54 ave. and 56 ave., in Buena Vista district, we      were assigned to work on what is known <I>in situ </I>vector control, which      means moving to a block and visiting people house by house, mainly searching      for mosquito larvae.The results of each inspection were reported in writing      on Model 9109, after each visit (a written evidence from the Ministry of Health      to record all visits performed by health workers involved in each anti-vector      brigade to each house). </font></P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">Once in the inspection      area, the CIGB&acute;s brigade was divided into small teams of two people.      Both my partner and I were involved in CIGB Heberprot-P project, so during      the inspection we used to talk and discuss about our specific work regarding      the extention of Heberprot-P DFU specialized services with this drug in Cuba.      In this respect we are not certain whether it was because Heberprot-P topics      were so deep in our minds, the fact is that after visiting the third house      in the first block, my partner and I felt the need to ask the inhabitants      the following questions: </font></P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">&bull; Are there      any diabetic patients living in this house? </font></P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">&bull; Do any of      your relatives suffer from diabetes? </font></P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">&bull; Have you heard      of a Cuban drug called Heberprot- P, effective in healing DFU? </font></P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">&bull; Do you know      where in the city the health center units in charge of treating DFU with Heberprot-P      are located? </font></P >       ]]></body>
<body><![CDATA[<P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">It is important to      highlight that in more than 300 houses, almost everybody acknowledged the      information given and many of them thought that delivering it in printing      would be even more effective. </font></P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">During those days,      we gave additional information about the treatment of DFU with Heberprot-P      in all houses in each block assigned including where to go in case of any      complications. For this reason we want to share the following proposal: </font></P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">That the Cuban Ministry      of Health analyzes the possibility of joinning the health promoter of each      zone of the municipality health department with the Cuban Anti-Vector brigades      (more than 30 000 employees) incharge of fighting mosquito infection throughout      the country (2) to help this ministry to diminish the number of amputations      in the Cuban population, by delivering printed information on Heberprot-P,      house by house, including the units that offer Heberprot-P for the treatment      of DFU and where they are located. If the above proposal is implemented, the      only aditional task to be performed by each brigade will be delivering a printed      document that explains what Heberprot-P is intended for. </font></P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">Upon acceptance,      a previous coordination with the Ministry of Health will be needed to have:      </font></P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">1. A printed document      to be shared either printed or in electronic format with information about:      diabetes, diabetic foot ulcers and its associated risk for amputation, a summary      about what Heberprot-P and its therapeutic action, also including a map with      all the 93 units that currently use Heberprot-P for the treatment of DFU.      </font></P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">2. The distribution      of updated information about DFU might be centralized by the health promoter      of each polyclinic. This person will be in charge of giving the documents      to the anti-vector staff in order to distribute them house by house, once      the inspection for vectors ends. </font></P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">Considering that      the delivery of the printed material will be performed without any further      information, the cost of the program will be very flexible and cheap. </font></P >       <P   ><font size="3" face="Verdana, Arial, Helvetica, sans-serif"><b>POTENTIAL ADVANTAGES</b></font><font size="2" face="Verdana, Arial, Helvetica, sans-serif">      </font></P >   <FONT size="+1">        <P   ><font size="2" face="Verdana, Arial, Helvetica, sans-serif">1. This proposal      launched for analysis fits the instructions given by the Cuban national authorities      to avoid extra expences in each governmental entity. </font></P >   <FONT size="+1">        <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">2. The proposal will      allow a new working attitude to potentiate the knowledge about Heberprot-P      in the Cuban population, a product registered in Cuba in the year 2006 and      included in the Basic Drug Frame of Cuba in the year 2007, with more than      93 centers in all provinces and that today are not receiving the expected      amount of patients. </font></P >       ]]></body>
<body><![CDATA[<P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">Professor Jos&eacute;      Fern&aacute;ndez Montequ&iacute;n, eminent Cuban Angiologist and pioneer in      extending the use of Heberprot-P in Cuba as well as in other countries, has      stated that this drug changed paradigms regarding treatments for DFU handling      (3). </font></P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">Nowadays promoting      the knowledge about Heberprot- P is one of the most important goals, not only      among medical personnel but also among diabetic patients, their relatives      and the whole population. No one better qualified than the anti-mosquito vector      brigades to help us to face this challenge. </font></P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">Novel contributions      in medicine as it was the introduction of anesthesia in surgery (the use of      ether as anesthesia was first described in 1846 (4) but it took 50 years extending      it use (5, 6)) and the use of antibiotics (Alexander Flemming discovered penicillin      in 1928 (7), but its use was not broaden until 1944) took many years spreading      their use. </font></P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">Lets imagine what      would happen if each of the more than 30 000 workers involved in the fight      against mosquito vectors, linked to the Deputy Direction of Epidemiology and      Hygiene of our Ministry of Health, qualified and authorized to visit each      Cuban family in their specific working sectors, delivers a dossier with information      about DFU in each house visited, how to trait it and where to go for free      of charge treatments with Heberprot-P. </font></P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">More than 1000 amputations      caused by DFU per year in Cuba show that there is still a lot of work to be      done in this matter. </font></P >       <P   > </P >   <FONT size="+1">        <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="3"><b>REFERENCES</b></font><font face="Verdana, Arial, Helvetica, sans-serif" size="2">      </font></P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">1. Ochoa O, Esperanza.      1998. Modelajes de vigilancia y lucha antivectorial en Cuba. Direcci&oacute;n      Nacional de Estad&iacute;sticas, Unidad Nacional Vigilancia y de Lucha Antivectorial.      </font></P >       <!-- ref --><P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">2. Noriega V, Ramos      I, Couterejuz&oacute;n L, Mart&iacute;n L, Mirabal M, D&iacute;az G. Situaci&oacute;n      organizacional de los grupos de control de vectores en Ciudad de La Habana.      Rev Cub Salud P&uacute;b 35(2). Disponible en: <a href="http://www.scielosp.org/pdf/rcsp/v35n2/spu18209.pdf">http://www.scielosp.org/pdf/rcsp/v35n2/spu18209.pdf</a>      (Consultado, julio 23 de 2010). </font></P >       <!-- ref --><P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">3. Montequ&iacute;n      JF, Santiesteban L. &iquest;Puede el Heberprot-P cambiar conceptos quir&uacute;rgicos      en el pie diab&eacute;tico? Conferencia impartida por el Dr. Montequ&iacute;n      en el marco del II Taller Nacional sobre la extensi&oacute;n del Heberprot-P.      Centro de Ingenier&iacute;a Gen&eacute;tica y Biotecnolog&iacute;a, 9-10 Abril,      2009. </font></P >       <!-- ref --><P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">4. Bigelow HJ. Insensibility      during surgical operations produced by inhalation. Boston Med Surg J 1846;35:309-17.      </font></P >       <!-- ref --><P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">5. Colton GQ. A true      history of the discovery of anaesthesia: A reply to Mrs. Elizabeth Whitman      Morton. New York, AG Sherwood, 1896. </font></P >       <!-- ref --><P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">6. Bigelow HJ. Surgical      Anaesthesia. Little, Brown, and Company. Boston, 1900. 378 p. </font></P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">7. Fleming A. The      antibacterial action of culture of a , with special reference to their use      in the isolation of B. influenzae. Brit J Exp Pathol 1929;10:226-36. </font></P >       <!-- ref --><P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">8. Sokoloff B. The      Story of Penicillin. Ziff-Davis Publishing Company, New York, 1945, 167 p.      </font></P >       <P   > </P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="2">Received in August,      2010.    <br>     </font><font face="Verdana, Arial, Helvetica, sans-serif" size="2">Accepted      for publication in September, 2010. </font></P >       <P   ><font face="Verdana, Arial, Helvetica, sans-serif" size="+1" color="#000000"><font size="2">Manuel      Ra&iacute;ces, </font> </font><font size="2" face="Verdana, Arial, Helvetica, sans-serif" color="#000000">Centro      de Ingenier&iacute;a Gen&eacute;tica y Biotecnolog&iacute;a, CIGB Ave. 31      entre 158 y 190, Cubanac&aacute;n, Playa, AP 6162, CP 10 600, Ciudad de La      Habana, Cuba E-mail: <a href="mailto:manuel.raices@cigb.edu.cu"> manuel.raices@cigb.edu.cu</a></font></P >   </font></font></font></font></font></font></font></font></font></DIV >      ]]></body><back>
<ref-list>
<ref id="B1">
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</person-group>
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</article>
