<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1028-4818</journal-id>
<journal-title><![CDATA[Multimed]]></journal-title>
<abbrev-journal-title><![CDATA[Multimed]]></abbrev-journal-title>
<issn>1028-4818</issn>
<publisher>
<publisher-name><![CDATA[Centro Provincial de Información de Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1028-48182021000200015</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Papel del sistema cannabinoide endógeno en el intestino]]></article-title>
<article-title xml:lang="en"><![CDATA[Role of the endogenous cannabinoid system in the gut]]></article-title>
<article-title xml:lang="pt"><![CDATA[Papel do sistema canabinoide endógeno no intestino]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pelaez Llorente]]></surname>
<given-names><![CDATA[Maythe]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ricardo Serrano]]></surname>
<given-names><![CDATA[Yoel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[La O Fernández]]></surname>
<given-names><![CDATA[Kacenys]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Martínez]]></surname>
<given-names><![CDATA[Talía Betania]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Granma Facultad de Ciencias Médicas de Bayamo ]]></institution>
<addr-line><![CDATA[ Granma]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital General Universitario Carlos Manuel de Céspedes  ]]></institution>
<addr-line><![CDATA[Bayamo Granma]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2021</year>
</pub-date>
<volume>25</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1028-48182021000200015&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1028-48182021000200015&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1028-48182021000200015&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El sistema cannabinoide endógeno es un nuevo sistema de comunicación intercelular que constituye una pieza crucial en la regulación de la función intestinal. Se realizó una revisión bibliográfica con el objetivo de describir cómo el sistema cannabinoide endógeno modula la función intestinal. Se consultaron un total de 31 referencias bibliográficas entre libros, revistas, tesis doctorales y artículos en internet. Se encontró que los endocannabinoides son inmunomoduladores a nivel intestinal, que el sistema cannabinoide endógeno regula la composición de la microbiota intestinal y esta a su vez determina la concentración de los endocannabinoides, además tanto la secreción como la motilidad intestinal disminuyen por estimulación del sistema cannabinoide endógeno. Los receptores de cannabinoides, los endocannabinoides anandamida y 2-araquidonoilglirerol y las proteínas responsables de su síntesis y degradación están ampliamente distribuidos en el intestino en condiciones fisiológicas, aumentando su expresión en la enfermedad inflamatoria intestinal lo que le permite regular la función intestinal en ambas condiciones. El sistema cannabinoide endógeno tiene un enorme potencial terapéutico en la enfermedad inflamatoria intestinal debido a los efectos inmunosupresores, antiinflamatorios y analgésicos que posee.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT The endogenous cannabinoid system is a new intercellular communication system that constitutes a crucial piece in the regulation of intestinal function. A bibliographic review was carried out in order to describe how the endogenous cannabinoid system modulates intestinal function. A total of 31 bibliographic references were consulted between books, magazines, doctoral theses and articles on the internet. It was found that endocannabinoids are immunomodulatory at the intestinal level, that the endogenous cannabinoid system regulates the composition of the intestinal microbiota and this in turn determines the concentration of endocannabinoids, in addition both secretion and intestinal motility decrease by stimulation of the endogenous cannabinoid system. The cannabinoid receptors, the endocannabinoids anandamide and 2-arachidonoylglirerol, and the proteins responsible for their synthesis and degradation are widely distributed in the intestine under physiological conditions, increasing their expression in inflammatory bowel disease, which allows it to regulate intestinal function in both conditions. The endogenous cannabinoid system has enormous therapeutic potential in inflammatory bowel disease due to its immunosuppressive, anti-inflammatory and analgesic effects.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO O sistema canabinoide endógeno é umnovo sistema de comunicação intercelular que constitui uma peça crucial na regulação da função intestinal. Foi realizada uma revisão bibliográfica para descrever como o sistema canabinoide endógeno modula a função intestinal. Foram consultadas 31referências bibliográficas entre livros, revistas, teses de doutorado e artigosna internet. Verificou-se que os endocanabinoides são imunomoduladores em nível intestinal, que o sistema canabinoide endógeno regula a composição da microbiota intestinal e esta, por sua vez, determina a concentração de endocanabinoides, além da diminuição da secreção e da motilidade intestinal pela estimulação do sistema canabinoide endógeno. Os receptores canabinoides, os endocanabinoides anandamida e 2-araquidonoilglirerol e as proteínas responsáveis &#8203;&#8203;por sua síntese e degradação estão amplamente distribuídos no intestino em condições fisiológicas, aumentando sua expressão em doenças inflamatórias intestinais que permitem regular a função intestinal em ambas as condições. O sistema canabinoide endógeno apresenta enorme potencial terapêutico na doença inflamatória intestinal devido aos seus efeitos imunossupressores, antiinflamatórios e analgésicos.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Sistema cannabinoide endógeno]]></kwd>
<kwd lng="es"><![CDATA[Secreción intestinal]]></kwd>
<kwd lng="es"><![CDATA[Motilidad intestinal]]></kwd>
<kwd lng="es"><![CDATA[Enfermedad inflamatoria intestinal]]></kwd>
<kwd lng="en"><![CDATA[Endogenous cannabinoid system]]></kwd>
<kwd lng="en"><![CDATA[Intestinal discharge]]></kwd>
<kwd lng="en"><![CDATA[Intestinal motility]]></kwd>
<kwd lng="en"><![CDATA[Inflammatory bowel disease]]></kwd>
<kwd lng="pt"><![CDATA[Sistema canabinóide endógeno]]></kwd>
<kwd lng="pt"><![CDATA[Descarga intestinal]]></kwd>
<kwd lng="pt"><![CDATA[Motilidade intestinal]]></kwd>
<kwd lng="pt"><![CDATA[Doença inflamatória intestinal]]></kwd>
</kwd-group>
</article-meta>
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