<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1028-9933</journal-id>
<journal-title><![CDATA[Revista Información Científica]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. inf. cient.]]></abbrev-journal-title>
<issn>1028-9933</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas Guantánamo]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1028-99332018000400766</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Inmunoterapia con vacunas Valergen por vía sublingual en asmáticos de Cabaiguán, Sancti Spíritus]]></article-title>
<article-title xml:lang="en"><![CDATA[Immunotherapy with Valergen sublingual vaccines in asthmatics patients from Cabaiguan to Sancti Spiritus]]></article-title>
<article-title xml:lang="pt"><![CDATA[Imunoterapia com vacinas de Valerge por via sublingual em asmáticos de Cabaiguán, Sancti Spíritus]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Perdomo Pulido]]></surname>
<given-names><![CDATA[Yusely]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Marín]]></surname>
<given-names><![CDATA[Álvaro Tomás]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez Pérez]]></surname>
<given-names><![CDATA[Emilia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Castro González]]></surname>
<given-names><![CDATA[Vladimir]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Iglesias]]></surname>
<given-names><![CDATA[Álvaro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Policlínico Universitario &#8220;Ramón Balboa Monzón&#8221;  ]]></institution>
<addr-line><![CDATA[ Sancti Spíritus]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Pediátrico Docente Provincial &#8220;José Martí Pérez&#8221;  ]]></institution>
<addr-line><![CDATA[ Sancti Spíritus]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Policlínico Universitario &#8220;Juan Miguel Martínez Puentes&#8221;  ]]></institution>
<addr-line><![CDATA[ Sancti Spíritus]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>97</volume>
<numero>4</numero>
<fpage>766</fpage>
<lpage>776</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1028-99332018000400766&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1028-99332018000400766&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1028-99332018000400766&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  la inmunoterapia sublingual se abre paso en la práctica alergológica, numerosos estudios avalan su eficacia y seguridad.  Objetivo:  caracterizar los resultados con el uso de las vacunas Valergen vía sublingual, en pacientes asmáticos, del municipio Cabaiguán.  Método:  se realizó una investigación descriptiva-prospectiva, de enero del 2013 a diciembre del 2016 en pacientes con diagnóstico de asma bronquial intermitente, persistente leve y moderado. El universo quedó constituido por 467 pacientes. La muestra fue de 44 pacientes, de todas las edades y sexos que reunían esas condiciones, fueron atendidos en consulta durante todo el periodo de estudio y evaluado cada paciente al cumplir tres años de tratamiento con inmunoterapia. Los datos fueron obtenidos de las historias clínicas y del registro de vacunación del departamento de alergia.  Resultados: predominaron los pacientes del sexo femenino, entre 5-14 años (34,1 %), el Dermatofagoide pteronyssinus fue el ácaro de mayor sensibilidad y utilización (45,4 %), a los 3 años de tratamiento predominaron los pacientes con un mejor control de sus síntomas (72,7 %), no se presentaron eventos adversos (79,5 %) en los pacientes, los presentados fueron clasificados como locales y/o sistémicos leves (20,5 %).  Conclusiones:  la inmunoterapia sublingual para el asma bronquial demostró ser segura y clínicamente favorable en los pacientes estudiados.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  sublingual immunotherapy makes its way into allergological practice and numerous studies confirm its effectiveness and safety.  Objective:  to characterize the results with the use of Valergen sublingual vaccines in asthmatic patients of Cabaiguan municipality.  Method:  a descriptive-prospective investigation was conducted from January 2013 to December 2016 in patients diagnosed with intermittent bronchial asthma, persistent, slow and moderate. The universe was constituted by 467 patients. The sample was of 44 patients, of all ages and sexes, who met these conditions, were seen in consultation during the studied period and evaluated each patient after three years of treatment with immunotherapy. The data were obtained from the clinical records and the vaccination record of the allergy department.  Results:  female patients between 5-14 years (34.1%), and Dermatophagoide pteronyssinus was the mite with the highest sensitivity and use (45.4%), after 3 years of treatment, patients with a better control of their symptoms (72.7%), there were no adverse events (79.5%) in the patients, those presented were classified as local and mild systemic (20.5%).  Conclusions:  sublingual immunotherapy for bronchial asthma proved to be safe and clinically favorable in the patients.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO  Introdução:  a imunoterapia sublingual faz parte da prática alergológica, e numerosos estudos confirmam sua eficácia e segurança.  Objetivo:  caracterizar os resultados com o uso de vacinas sublinguais de Valergen, em pacientes asmáticos, do município de Cabaiguán.  Método:  inquérito descritivo-prospectivo foi realizado no período de janeiro de 2013 a dezembro de 2016 em pacientes com diagnóstico de asma brônquica intermitente, persistente leve e moderada. O universo foi constituído por 467 pacientes. A amostra foi de 44 pacientes, de todas as idades e sexos que preencheram essas condições, foram atendidos em consulta durante todo o período do estudo e avaliaram cada paciente após três anos de tratamento com imunoterapia. Os dados foram obtidos a partir dos registros clínicos e do registro de vacinação do departamento de alergia.  Resultados:  predominaram pacientes do sexo feminino, entre 5-14 anos (34,1%), Dermatophagoide pteronyssinus foi o ácaro com maior sensibilidade e utilização (45,4%), após 3 anos de tratamento, pacientes com melhor controle de seus sintomas (72,7%), não houve eventos adversos (79,5%) nos pacientes, aqueles apresentados foram classificados como sistêmicos locais e / ou leves (20,5%).  Conclusões:  a imunoterapia sublingual para asma brônquica mostrou-se segura e clinicamente favorável nos pacientes estudados.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[ácaros]]></kwd>
<kwd lng="es"><![CDATA[extracto alergénico]]></kwd>
<kwd lng="es"><![CDATA[inmunoterapia sublingual]]></kwd>
<kwd lng="es"><![CDATA[vacunas Valergen]]></kwd>
<kwd lng="en"><![CDATA[mites]]></kwd>
<kwd lng="en"><![CDATA[allergenic extract]]></kwd>
<kwd lng="en"><![CDATA[sublingual immunotherapy]]></kwd>
<kwd lng="en"><![CDATA[vaccines Valergen]]></kwd>
<kwd lng="pt"><![CDATA[ácaros]]></kwd>
<kwd lng="pt"><![CDATA[extracto de alergeno]]></kwd>
<kwd lng="pt"><![CDATA[SLIT]]></kwd>
<kwd lng="pt"><![CDATA[vacinas Valergen]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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