<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1028-9933</journal-id>
<journal-title><![CDATA[Revista Información Científica]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. inf. cient.]]></abbrev-journal-title>
<issn>1028-9933</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas Guantánamo]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1028-99332018000601111</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Comportamiento de malformaciones congénitas en Guantánamo durante el año 2010]]></article-title>
<article-title xml:lang="en"><![CDATA[Behavior of congenital malformations in Guantánamo during the year 2010]]></article-title>
<article-title xml:lang="pt"><![CDATA[Comportamento de malformações congênitas em Guantánamo durante o ano de 2010]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ramírez Lantigua]]></surname>
<given-names><![CDATA[Fidel Alejandro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez Velázquez]]></surname>
<given-names><![CDATA[Mireya]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Leyva Matos]]></surname>
<given-names><![CDATA[Luis Ángel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Barcelay Leyva]]></surname>
<given-names><![CDATA[Favián Alexis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez Martínez]]></surname>
<given-names><![CDATA[María]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Facultad de Ciencias Médicas  ]]></institution>
<addr-line><![CDATA[ Guantánamo]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Policlínico Universitario &#8220;Asdrúbal López Vázquez&#8221;  ]]></institution>
<addr-line><![CDATA[ Guantánamo]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Clínico Quirúrgico &#8220;Hermanos Ameijeiras&#8221;  ]]></institution>
<addr-line><![CDATA[ Ciudad de La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Policlínico Universitario &#8220;Emilio Daudinot Bueno&#8221;  ]]></institution>
<addr-line><![CDATA[ Guantánamo]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2018</year>
</pub-date>
<volume>97</volume>
<numero>6</numero>
<fpage>1111</fpage>
<lpage>1123</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1028-99332018000601111&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1028-99332018000601111&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1028-99332018000601111&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: en el desarrollo histórico de la humanidad las malformaciones congénitas se han presentado teniendo distintas explicaciones, atribuyéndoles significados que oscilan entre ciencia y superstición. Con la expresión diagnóstica prenatal de los defectos congénitos se agrupan aquellas acciones diagnósticas encaminadas a descubrir durante el embarazo un defecto congénito.  Objetivo: analizar el comportamiento de algunas variables en el pesquisaje de malformaciones congénitas en gestantes de la provincia de Guantánamo.  Método:  se realizó un estudio longitudinal retrospectivo sobre malformaciones congénitas en gestantes, en el período enero-diciembre de 2010. El universo está constituido por 7 585 nacimientos y la muestra por 76 malformaciones que se produjeron en ese período, con utilización del muestreo aleatorio simple. Se analizaron las siguientes variables: edad, municipio de procedencia, tipo de malformación congénita, vivo o fallecido, resultado de AFP, resultado de ultrasonido en el primer y segundo trimestre, diagnóstico prenatal de hemoglobinopatías, diagnóstico prenatal de errores innatos del metabolismo y resultado del diagnóstico prenatal citogenético.  Resultados:  las tasas más altas correspondiendo a los municipios de Caimanera, Baracoa y Maisí, con 11,2; 2,74 y 2,28; respectivamente. Las malformaciones más frecuentes se encontraron en el sistema nervioso central con el 23,68 %, cardiovascular y osteomioarticular, con 19,73 y 18,42 %, cada uno. Los municipios con mayor tasa de malformaciones congénitas fueron Imías, Caimanera y Niceto Pérez con 30,86; 28,09 y 12,98 por mil.  Conclusiones:  la tasa de mortalidad por malformaciones congénitas en la provincia de Guantánamo durante el 2010 fue superior a la reportada nacionalmente. La frecuencia de malformaciones congénitas durante el año 2010 en la provincia Guantánamo fue inferior a la reportada en la literatura. El grupo etario con predominio de malformaciones congénitas fue el de 20 a 29 años de edad. Los medios diagnósticos más utilizados fueron el ultrasonido, seguidas de la alfafetoproteínas, y los estudios citogenéticos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  in the historical development of humanity, congenital malformations have been presented with different explanations, attributing meanings that oscillate between science and superstition. With the prenatal diagnostic expression of congenital defects are grouped those diagnostic actions aimed at discovering a congenital defect during pregnancy.  Objective:  to analyze the behavior of some variables in the screening of congenital malformations in pregnant women in the province of Guantánamo.  Method:  a retrospective longitudinal study was performed on congenital malformations in pregnant women, in the period January-December 2010. The universe is constituted by 7 585 births and the sample by 76 malformations that occurred in that period, using simple random sampling. The following variables were analyzed: age, municipality of origin, type of congenital malformation, alive or deceased, AFP result, ultrasound result in the first and second trimester, prenatal diagnosis of hemoglobinopathies, prenatal diagnosis of inborn errors of metabolism and outcome of the prenatal cytogenetic diagnosis.  Results:  the highest rates corresponding to the municipalities of Caimanera, Baracoa and Maisí, with 11.2; 2.74 and 2.28; respectively. The most frequent malformations were found in the central nervous system with 23.68%, cardiovascular and osteomyoarticular, with 19.73 and 18.42%, each. The municipalities with the highest rate of congenital malformations were Imías, Caimanera and Niceto Pérez with 30.86; 28.09 and 12.98 per thousand.  Conclusions:  the mortality rate due to congenital malformations in the province of Guantanamo during 2010 was higher than that reported nationally. The frequency of congenital malformations during the year 2010 in Guantanamo province was lower than that reported in the literature. The age group with predominance of congenital malformations was 20 to 29 years of age. The most used diagnostic means were ultrasound, followed by alpha-fetoproteins, and cytogenetic studies.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO  Introdução:  no desenvolvimento histórico da humanidade, malformações congênitas foram apresentadas com diferentes explicações, atribuindo significados que oscilam entre ciência e superstição. Com a expressão diagnóstica pré-natal de defeitos congênitos agrupam-se aquelas ações diagnósticas que visam descobrir um defeito congênito durante a gravidez.  Objetivo:  analisar o comportamento de algumas variáveis na triagem de malformações congênitas em gestantes da província de Guantánamo.  Método:  Um estudo retrospectivo longitudinal de defeitos congénitos em mulheres grávidas foi realizada em Janeiro-Dezembro de 2010. O universo consiste em 7585 nascimentos e as malformações amostra 76 que ocorreram durante o mesmo período, com o uso de amostragem aleatória . idade, cidade de origem, tipo de malformação congênita, viva ou morta, resultado AFP, o resultado da ultra-sonografia no primeiro e segundo diagnóstico pré-natal trimestre de hemoglobinopatias, diagnóstico pré-natal de erros inatos do metabolismo e resultar Foram analisadas as seguintes variáveis diagnóstico citogenético pré-natal.  Resultados:  as maiores taxas correspondentes aos municípios de Caimanera, Baracoa e Maisí, com 11,2; 2,74 e 2,28; respectivamente. Os defeitos mais comuns foram encontradas no sistema nervoso central, com 23,68 %, cardiovascular e osteomioarticular com 19,73 e 18,42 %, cada. Os municípios com maior índice de malformações congênitas foram Imías, Caimanera e Niceto Pérez com 30,86; 28,09 e 12,98 por mil.  Conclusões:  a taxa de mortalidade por malformações congênitas na província de Guantánamo em 2010 foi superior à relatada nacionalmente. A freqüência de malformações congênitas durante o ano de 2010 na província de Guantánamo foi menor do que a relatada na literatura. A faixa etária com predomínio de malformações congênitas foi de 20 a 29 anos de idade. Os meios diagnósticos mais utilizados foram a ultra-sonografia, seguida das alfa-fetoproteínas e os estudos citogenéticos.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[malformaciones congénitas]]></kwd>
<kwd lng="es"><![CDATA[cromosomopatías]]></kwd>
<kwd lng="es"><![CDATA[alfafetoproteínas]]></kwd>
<kwd lng="en"><![CDATA[congenital malformations]]></kwd>
<kwd lng="en"><![CDATA[chromosomopathies]]></kwd>
<kwd lng="en"><![CDATA[alpha-fetoproteins]]></kwd>
<kwd lng="pt"><![CDATA[malformações congênitas]]></kwd>
<kwd lng="pt"><![CDATA[cromossomopatias]]></kwd>
<kwd lng="pt"><![CDATA[alfa-fetoproteínas]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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