<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1028-9933</journal-id>
<journal-title><![CDATA[Revista Información Científica]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. inf. cient.]]></abbrev-journal-title>
<issn>1028-9933</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas Guantánamo]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1028-99332019000400524</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Aspectos epidemiológicos, clínicos y quirúrgicos de los tumores cerebrales metastásicos]]></article-title>
<article-title xml:lang="en"><![CDATA[Epidemiological, clinical and surgical aspects of metastatic brain tumors]]></article-title>
<article-title xml:lang="pt"><![CDATA[Aspectos epidemiológicos, clínicos e cirúrgicos dos tumores cerebrais metastáticos]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hodelin Maynard]]></surname>
<given-names><![CDATA[Edwin Humberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cardona Castillo]]></surname>
<given-names><![CDATA[Marianela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Maynard Bermúdez]]></surname>
<given-names><![CDATA[Gladys Ivette]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Maynard Bermúdez]]></surname>
<given-names><![CDATA[Ruby Esther]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Internacional de Restauración Neurológica (CIREN)  ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital General Docente &#8220;Dr. Agostinho Neto&#8221;  ]]></institution>
<addr-line><![CDATA[ Guantánamo]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Facultad de Ciencias Médicas  ]]></institution>
<addr-line><![CDATA[ Guantánamo]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Universidad de Ciencias Médicas  ]]></institution>
<addr-line><![CDATA[ Guantánamo]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<volume>98</volume>
<numero>4</numero>
<fpage>524</fpage>
<lpage>539</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1028-99332019000400524&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1028-99332019000400524&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1028-99332019000400524&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  los tumores que se diseminan en el cerebro, provenientes de una neoplasia primaria localizada en otros órganos del cuerpo son conocidos como tumores cerebrales metastásicos. Se estima que el 25 % de los tumores malignos en otros lugares del organismo provocan metástasis en la cabeza.  Objetivo:  sistematizar los aspectos clínicos, epidemiológicos y quirúrgicos de los tumores cerebrales metastásicos, así como las herramientas diagnósticas y terapéuticas necesarias para ofrecerles al enfermo y familiares las mejores alternativas ante la enfermedad.  Método:  se realizó una revisión narrativa a partir del estudio documental de revisiones sistemáticas, metaanálisis, guías de práctica clínica, artículos originales y tesis doctorales que se encontraron en las bases de datos electrónicas.  Resultados:  la incidencia de la metástasis cerebral varía en dependencia de la localización del tumor primario. En los adultos, la incidencia más alta se observó entre la quinta y séptima década de vida, sin diferencias en el sexo. Los tumores cerebrales tienen diferentes formas de presentación clínica, entre ellas se encontraron el síndrome de hipertensión intracraneal, signos focales, crisis epilépticas y síndrome endocrino. Los tres componentes primordiales del manejo de pacientes con metástasis cerebral fueron las drogas no quimioterapéuticas y quimioterapéuticas, la intervención quirúrgica para la exéresis tumoral y la radioterapia.  Conclusiones:  los tumores metastásicos cerebrales constituyen un problema de salud con incidencia creciente, con un cuadro sindrómico complejo y polimorfo, poseen amplio arsenal terapéutico que abarca las drogas no quimioterapéuticas, la quimioterapia, la quirúrgica y la radioterapia las cuales deben ser ajustadas a las características de cada paciente para lograr una sobrevida lo más larga posible, con mayor calidad de vida.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  tumors that spread in the brain, from a primary neoplasm located in other organs of the body are known as metastatic brain tumors. It is estimated that 25% of malignant tumors in other parts of the body cause head metastases.  Objective:  to systematize the clinical, epidemiological and surgical aspects of metastatic brain tumors, as well as the diagnostic and therapeutic tools necessary to offer the patient and family the best alternatives to the disease.  Method:  a narrative review was carried out based on the documentary study of systematic reviews, meta-analysis, clinical practice guides, original articles and doctoral theses that were found in the electronic databases.  Results:  the incidence of brain metastasis varies depending on the location of the primary tumor. In adults, the highest incidence was observed between the fifth and seventh decade of life, without differences in sex. Brain tumors have different forms of clinical presentation, including intracranial hypertension syndrome, focal signs, epileptic seizures and endocrine syndrome. The three primary components of the management of patients with cerebral metastases were non-chemotherapeutic and chemotherapeutic drugs, surgical intervention for tumor excision and radiotherapy.  Conclusions:  metastatic brain tumors constitute a health problem with increasing incidence, with a complex syndromic and polymorphic picture, they have a wide therapeutic arsenal that includes non-chemotherapeutic drugs, chemotherapy, surgery and radiotherapy which must be adjusted to the characteristics of each patient to achieve a survival as long as possible, with a better quality of life.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO  Introdução:  tumores que se espalham no cérebro, a partir de uma neoplasia primária localizada em outros órgãos do corpo, são conhecidos como tumores cerebrais metastáticos. Estima-se que 25% dos tumores malignos em outras partes do corpo causem metástases na cabeça.  Objetivo:  sistematizar os aspectos clínicos, epidemiológicos e cirúrgicos dos tumores cerebrais metastáticos, bem como as ferramentas diagnósticas e terapêuticas necessárias para oferecer ao paciente e à família as melhores alternativas para a doença.  Método:  foi realizada uma revisão narrativa baseada no estudo documental de revisões sistemáticas, metanálises, guias de prática clínica, artigos originais e teses de doutorado encontradas nas bases de dados eletrônicas.  Resultados:  a incidência de metástases cerebrais varia de acordo com a localização do tumor primário. Nos adultos, a maior incidência foi observada entre a quinta e a sétima década de vida, sem diferenças entre os sexos. Os tumores cerebrais têm diferentes formas de apresentação clínica, incluindo síndrome de hipertensão intracraniana, sinais focais, convulsões epilépticas e síndrome endócrina. Os três componentes principais do tratamento de pacientes com metástases cerebrais foram medicamentos não quimioterápicos e quimioterápicos, intervenção cirúrgica para excisão de tumores e radioterapia.  Conclusões:  os tumores cerebrais metastáticos constituem um problema de saúde com incidência crescente, com quadro sindrômico e polimórfico complexo, possuem amplo arsenal terapêutico que abrange medicamentos não quimioterápicos, quimioterapia, cirurgia e radioterapia, que devem ser ajustados às características de cada paciente para alcançar a sobrevivência o maior tempo possível, com uma melhor qualidade de vida.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[tumor cerebral]]></kwd>
<kwd lng="es"><![CDATA[tumores cerebrales metastásicos]]></kwd>
<kwd lng="es"><![CDATA[metástasis cerebrales]]></kwd>
<kwd lng="en"><![CDATA[brain tumor]]></kwd>
<kwd lng="en"><![CDATA[metastatic brain tumors]]></kwd>
<kwd lng="en"><![CDATA[brain metastases]]></kwd>
<kwd lng="pt"><![CDATA[tumor cerebral]]></kwd>
<kwd lng="pt"><![CDATA[tumores cerebrais metastáticos]]></kwd>
<kwd lng="pt"><![CDATA[metástases cerebrais]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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