<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1028-9933</journal-id>
<journal-title><![CDATA[Revista Información Científica]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. inf. cient.]]></abbrev-journal-title>
<issn>1028-9933</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas Guantánamo]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1028-99332023000100032</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Impacto cognitivo del uso crónico de opioides]]></article-title>
<article-title xml:lang="en"><![CDATA[Cognitive impact of chronic opioid use]]></article-title>
<article-title xml:lang="pt"><![CDATA[Impacto cognitivo do uso crônico de opioides]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Macedo-Soares]]></surname>
<given-names><![CDATA[Lara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Estrin]]></surname>
<given-names><![CDATA[Marcelo Adrián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Abierta Interamericana Facultad de Medicina y Ciencias de la Salud ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Argentina</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>102</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1028-99332023000100032&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1028-99332023000100032&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1028-99332023000100032&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: El impacto del uso crónico de opioides se ha relacionado con una amplia gama de desórdenes cognitivos, que abarcan desde deficiencias menores en habilidades cognitivas hasta problemas en habilidades como atención, aprendizaje, memoria y funciones ejecutivas.  Objetivo:  Realizar una revisión sistemática para investigar el impacto cognitivo en pacientes que usan opioides crónicamente y evaluar la gravedad de ese impacto.  Método: Se evaluaron ensayos clínicos aleatorizados, estudios de casos y controles, cohortes prospectivas y retrospectivas en dos bases de datos: PubMed y Cochrane Central, con la utilización de los siguientes términos en su búsqueda: "analgesic opioids", "cognitive dysfunction"," cognition impairments", "chronic disease" y "abuse, substance". La búsqueda fue en los idiomas inglés, español y portugués de estudios realizados en humanos adultos en uso crónico de opioides y su impacto cognitivo.  Resultados:  Fueron seleccionados 7 estudios, 5 de los cuales los pacientes hicieron uso de tramadol y fue constatado el impacto cognitivo negativo, un estudio con el uso de tapentadol con impacto positivo sobre la cognición y un estudio con el uso de hidrocodona con impacto positivo en la neurocognición de los pacientes.  Conclusiones:  A pesar de las limitaciones encontradas, como conclusión se considera que el tramadol tiene un impacto negativo en la neurocognición, lo que no ocurre en relación con el tapentadol y la hidrocodona, que presentarán una mejoría en la calidad de vida y cognición de los pacientes.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  The impact of chronic opioid use has been related to a wide range of cognitive disorders, ranging from minor deficiencies in cognitive abilities to problems in abilities such as attention, learning, memory, and executive functions.  Objective:  To carry out a systematic review to research the cognitive impact in patients who use opioids chronically and to assess the severity of this impact.  Method:  Randomized clinical trials, case-control studies, prospective and retrospective cohorts were evaluated in two databases: PubMed and Cochrane Central, using the following search terms: "analgesic opioids", "cognitive dysfunction", "cognition impairments", "chronic disease" and "abuse, substance". The search was in English, Spanish, and Portuguese for studies conducted in adult humans with chronic opioid use and its cognitive impact.  Results:  Seven studies were selected, five of which the patients used tramadol and the negative cognitive impact was verified, a study with the use of tapentadol with a positive impact on cognition and a study with the use of hydrocodone with a positive impact on neurocognition of patients.  Conclusions:  despite the limitations found, as a conclusion it is considered that tramadol has a negative impact on neurocognition, which does not occur in relation to tapentadol and hydrocodone, which will present an improvement in the quality of life and cognition of patients.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO  Introdução:  O impacto do uso crônico de opioides tem sido relacionado a uma ampla gama de distúrbios cognitivos, desde pequenas deficiências nas habilidades cognitivas até problemas em habilidades como atenção, aprendizado, memória e funções executivas.  Objetivo:  Realizar uma revisão sistemática para investigar o impacto cognitivo em pacientes que fazem uso crônico de opioides e avaliar a gravidade desse impacto.  Método:  Ensaios clínicos randomizados, estudos de caso-controle, coortes prospectivas e retrospectivas foram avaliados em duas bases de dados: PubMed e Cochrane Central, usando os seguintes termos em sua busca: "analgesic opioids", "cognitive dysfunção", "cognitive impairments", "doença crônica" e "abuso, substância". A busca foi em inglês, espanhol e português para estudos conduzidos em humanos adultos sobre o uso crônico de opioides e seu impacto cognitivo.  Resultados:  Foram selecionados 7 estudos, 5 dos quais os pacientes usaram tramadol e foi verificado o impacto cognitivo negativo, um estudo com o uso de tapentadol com impacto positivo na cognição e um estudo com o uso de hidrocodona com impacto positivo na neurocognição de pacientes.  Conclusões:  Apesar das limitações encontradas, como conclusão considera-se que o tramadol tem impacto negativo na neurocognição, o que não ocorre em relação ao tapentadol e hidrocodona, que apresentarão melhora na qualidade de vida e cognição dos pacientes.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[opioides]]></kwd>
<kwd lng="es"><![CDATA[narcóticos]]></kwd>
<kwd lng="es"><![CDATA[cognición]]></kwd>
<kwd lng="es"><![CDATA[disfunción cognitiva]]></kwd>
<kwd lng="es"><![CDATA[enfermedad crónica]]></kwd>
<kwd lng="es"><![CDATA[abuso]]></kwd>
<kwd lng="es"><![CDATA[sustancias]]></kwd>
<kwd lng="en"><![CDATA[opioids]]></kwd>
<kwd lng="en"><![CDATA[narcotics]]></kwd>
<kwd lng="en"><![CDATA[cognition]]></kwd>
<kwd lng="en"><![CDATA[cognitive dysfunction]]></kwd>
<kwd lng="en"><![CDATA[chronic disease]]></kwd>
<kwd lng="en"><![CDATA[abuse]]></kwd>
<kwd lng="en"><![CDATA[substances]]></kwd>
<kwd lng="pt"><![CDATA[opioides]]></kwd>
<kwd lng="pt"><![CDATA[narcóticos]]></kwd>
<kwd lng="pt"><![CDATA[conhecimento]]></kwd>
<kwd lng="pt"><![CDATA[disfunção cognitiva]]></kwd>
<kwd lng="pt"><![CDATA[doença crônica]]></kwd>
<kwd lng="pt"><![CDATA[Abuso]]></kwd>
<kwd lng="pt"><![CDATA[substâncias]]></kwd>
</kwd-group>
</article-meta>
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