<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1028-9933</journal-id>
<journal-title><![CDATA[Revista Información Científica]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. inf. cient.]]></abbrev-journal-title>
<issn>1028-9933</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas Guantánamo]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1028-99332024000100016</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Diagnóstico de tuberculosis con ensayo Xpert® MTB/RIF en la región oriental de Cuba]]></article-title>
<article-title xml:lang="en"><![CDATA[Diagnosis of tuberculosis withXpert® MTB/RIF test in the easternregion of Cuba]]></article-title>
<article-title xml:lang="pt"><![CDATA[Diagnóstico de tuberculose com ensaio Xpert® MTB/RIF na região leste de Cuba]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Carmenates Ricardo]]></surname>
<given-names><![CDATA[Ernesto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Díaz]]></surname>
<given-names><![CDATA[Marilin]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Centro Provincial de Higiene, Epidemiología y Microbiología de Holguín  ]]></institution>
<addr-line><![CDATA[ Holguín]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<volume>103</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1028-99332024000100016&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1028-99332024000100016&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1028-99332024000100016&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: La infección por tuberculosis repercute en el mundo a pesar de los años de estudio y avances tecnológicos en su diagnóstico. El ensayo Xpert® MTB/RIF permite, en gran medida, la identificación del bacilo de Koch en cualquier muestra patológica, y lo hace con una alta sensibilidad, especificidad y rapidez con respecto a otros métodos.  Objetivo: Realizar el diagnóstico de tuberculosis con ensayo Xpert® MTB/RIF.  Método: Se realizó un estudio transversal en 46 muestras analizadas (n=46) de las provincias orientales de Cuba con ensayo Xpert® MTB/RIF, entre abril y septiembre de 2023, por el Centro Provincial de Higiene, Epidemiología y Microbiología de Holguín. Las variables estudiadas fueron: provincia de procedencia, edad, sexo, tipo de muestra, factores de riesgo, resultado al ensayo y resistencia a la rifampicina.  Resultados: Santiago de Cuba y Guantánamo fueron las provincias que mayor cantidad de casos reportaron, con 14 casos cada una (30,4 %). El sexo masculino fue el de mayor incidencia, 33 casos (71,7 %), independientemente de la provincia. El grupo de edad de 25 a 34 años fue el de mayor prevalencia, con el 26,1 %. Los grupos de riesgos más afectados fueron: los fumadores (37,0 %), los reclusos (32,6 %), los adultos mayores de 60 años (26,6 %) y los alcohólicos (23,9 %).  Conclusiones:  La introducción del GeneXpert en su diagnóstico es muy efectivo, por su alta sensibilidad y especificidad con relación a los estudios tradicionales, como son la baciloscopia y el cultivo, además de la rapidez en la obtención del resultado.Informa también sobre la resistencia a la rifampicina, atribuible al gen rpo&#946;, lo que resulta muy oportuno en momentos en que la multidrogorresistencia aumenta aceleradamente.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Tuberculosis infection affects the world despite years of study and technological advances in its diagnosis.The Xpert® MTB/RIF test allows, to a largeextent, the identification of Koch bacillus in any pathological sample, and does so with high sensitivity, specificity and speed compared too ther methods.  Objective: To diagnose tuberculosis with the Xpert® MTB/RIF test.  Method:  A cross-sectional study was carried out on 46 analyzed samples (n 46) from the eastern provinces of Cuba with the Xpert® MTB/RIF test, between April and September 2023, by the Centro Provincial de Higiene, Epidemiología y Microbiología de Holguín (Provincial Center of Hygiene, Epidemiology and Microbiology of Holguín).The variables studied were: province of origin, age, sex, type of sample, risk factors, test resultand resistance to rifampicin.  Results:  Santiago de Cuba and Guantánamo were the provinces that reported the highest number of cases, with 14 cases each(30.4%).The maleshad the highest incidence, 33 cases (71.7%), regardless of the province.The age group of 25 to 34 years was the one with the highest prevalence, with 26.1%.The most affected risk groups were: smokers (37.0%), prisoners (32.6%), adults over 60 years of age (26.6%) and alcoholics (23.9%).  Conclusions:  The introduction of GeneXpert in tuberculosis diagnosis is very effective, due to its high sensitivity and specificity in relation to traditional studies, such as smear microscopy and culture, in addition to the speed in obtaining the result. It also reports on resistance to rifampicin, attributable to the rpo&#946; gene, which is timely at a moment when multidrug resistance is increasing rapidly.]]></p></abstract>
<abstract abstract-type="short" xml:lang="pt"><p><![CDATA[RESUMO  Introdução:  A infecção tuberculosa afeta o mundo apesar de anos de estudo e avanços tecnológicos no seu diagnóstico.O ensaio Xpert® MTB/RIF permite, em grande medida, a identificação do bacilo de Koch em qualquer amostra patológica, e fá-lo com elevada sensibilidade, especificidade e rapidez em comparação com outros métodos.  Objetivo:  Diagnosticar tuberculose com o ensaio Xpert® MTB/RIF.  Método:  Foi realizado um estudo transversal em 46 amostras analisadas (n 46) das províncias orientais de Cuba com o ensaio Xpert® MTB/RIF, entre abril e setembro de 2023, pelo Centro Provincial de Higiene, Epidemiologia e Microbiologia de Holguín.As variáveis estudadas foram: província de origem, idade, sexo, tipo de amostra, fatores de risco, resultado de exame e resistência à rifampicina.  Resultados:  Santiago de Cuba e Guantánamo foram as províncias que notificaram o maior número de casos, com 14 casos cada (30,4%).O sexo masculino teve a maior incidência, 33 casos (71,7%), independentemente da província.A faixa etária de 25 a 34 anos foi a que apresentou maior prevalência, com 26,1%.Os grupos de risco mais acometidos foram: fumantes (37,0%), presidiários (32,6%), adultos acima de 60 anos (26,6%) e alcoolistas (23,9%).  Conclusões:  A introdução do GeneXpert no seu diagnóstico é muito eficaz, devido à sua alta sensibilidade e especificidade em relação aos estudos tradicionais, como baciloscopia e cultura, além da rapidez na obtenção do resultado.Também relata a resistência à rifampicina, atribuível ao gene rpo&#946;, que é muito oportuna numa altura em que a resistência a múltiplos medicamentos está a aumentar rapidamente.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[tuberculosis]]></kwd>
<kwd lng="es"><![CDATA[factores de riesgos]]></kwd>
<kwd lng="es"><![CDATA[resistencia a rifampicina]]></kwd>
<kwd lng="es"><![CDATA[Mycobacterium tuberculosis]]></kwd>
<kwd lng="en"><![CDATA[tuberculosis]]></kwd>
<kwd lng="en"><![CDATA[risk factors]]></kwd>
<kwd lng="en"><![CDATA[rifampicin resistance]]></kwd>
<kwd lng="en"><![CDATA[Mycobacterium tuberculosis]]></kwd>
<kwd lng="pt"><![CDATA[tuberculose]]></kwd>
<kwd lng="pt"><![CDATA[fatores de risco]]></kwd>
<kwd lng="pt"><![CDATA[resistência à rifampicina]]></kwd>
<kwd lng="pt"><![CDATA[Mycobacterium tuberculose]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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