<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1029-3019</journal-id>
<journal-title><![CDATA[MEDISAN]]></journal-title>
<abbrev-journal-title><![CDATA[MEDISAN]]></abbrev-journal-title>
<issn>1029-3019</issn>
<publisher>
<publisher-name><![CDATA[Centro Provincial de Información de Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1029-30192020000400565</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Variabilidad de los resultados de la PCR evolutiva en pacientes con la COVID-19]]></article-title>
<article-title xml:lang="en"><![CDATA[Variability of the evolutionary PCR results in patients with COVID -19]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez Hernández]]></surname>
<given-names><![CDATA[Ernesto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cardona Gordo]]></surname>
<given-names><![CDATA[Odalis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferrer Castro]]></surname>
<given-names><![CDATA[Jacno Erik]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Fouces]]></surname>
<given-names><![CDATA[Fernando]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Despaigne Bicet]]></surname>
<given-names><![CDATA[Adrial]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas Hospital Militar Dr. Joaquín Castillo Duany ]]></institution>
<addr-line><![CDATA[Santiago de Cuba ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<volume>24</volume>
<numero>4</numero>
<fpage>565</fpage>
<lpage>577</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1029-30192020000400565&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1029-30192020000400565&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1029-30192020000400565&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La nueva especie de coronavirus (COVID-19), ha generado escenarios de emergencia sanitaria en muchos países de todos los continentes.  Objetivo: Caracterizar la variabilidad de los resultados de la PCR evolutiva en pacientes con la COVID-19.  Métodos:  Se realizó un estudio observacional, descriptivo longitudinal y prospectivo de 68 pacientes con la COVID-19 (niños y adultos de ambos sexos) ingresados en el Hospital Militar Dr. Joaquín Castillo Duany de Santiago de Cuba, desde el 12 de marzo hasta el 30 de abril de 2020. Para la colecta de la muestra virológica se realizó el hisopado faríngeo y nasal, cuyo análisis de la PCR-RT se procesó en el centro de referencia territorial. Se incluyeron variables sociodemográficas, epidemiológicas y de gestión, entre otras.  Resultados: En la serie predominó el sexo femenino (52,9 %). Al total de los pacientes se le realizaron 2 pruebas de PCR-RT; evolutivamente, 40,0 % de los niños y 10,0 % de los adultos mayores requirieron una tercera muestra virológica. En el segundo y tercer tercios del período de observación clínica y epidemiológica, la comunicación del resultado promedió 1,5 días (DE±0,6) y 3,2 días (DE±1,6), respectivamente. A los 15 días de tratamiento en todos los grupos poblacionales hubo casos positivos activos; asimismo, 60,0 % de los que permanecieron con carga viral entre 16-20 días fueron asintomáticos, al igual que 66,7 % de aquellos con más de 20 días de medicación.  Conclusiones: Independientemente de la edad y la duración del tratamiento médico, algunos individuos se mantuvieron con carga viral detectable. No es aconsejable el egreso de pacientes sin que la PCR-RT resulte negativa, sobre todo para los casos asintomáticos, en quienes el seguimiento evolutivo ha sido menos favorable.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  The new coronavirus specimen (COVID-19), has generated scenarios of sanitary emergencies in many countries from all continents.  Objective:  To characterize the variability of the PCR evolutionary results in patients with COVID-19.  Methods:  An observational, descriptive, prospective and cross-sectional study was carried out in 68 patients with COVID-19 (children and adults from both sexes) admitted in Dr. Joaquín Castillo Duany Military Hospital in Santiago de Cuba, from March 12th to April 30th, 2020. To collect the virological, the nasal and pharyngeal use of isotope was carried out, which analysis of PCR-RT was processed in the territorial reference center. Management, social, demographic and epidemiological variables were included, among others.  Results:  Female sex prevailed in the series (52.9 %). Two PCR-RT fast tests were made to all the patients, through their clinical course, 40.0 % of the children and 10.0 % of the aged patients requiered a third virological test. In the second and third third of the clinical and epidemiological observation period, the report of the result averaged 1.5 days (SD ± 0.6) and 3.2 days (SD±1.6), respectively. After 15 days of treatment there were active positive cases in all populational groups; likewise 60.0 % of those with viral charge between 16-20 days were asymptomatic, as the 66.7 % of those with more than 20 days under medication.  Conclusions:  Independently from the age and duration of the medical treatment, some patients remained with detectable viral charge. It is not adviced to discharge patients without a negative PCR-RT, above all for asympthomatic cases, in whom the evolutionary clinical course has been less favorable.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[pandemia]]></kwd>
<kwd lng="es"><![CDATA[coronavirus]]></kwd>
<kwd lng="es"><![CDATA[reacción en cadena de la polimerasa]]></kwd>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="es"><![CDATA[carga viral detectable]]></kwd>
<kwd lng="en"><![CDATA[pandemic]]></kwd>
<kwd lng="en"><![CDATA[coronavirus]]></kwd>
<kwd lng="en"><![CDATA[polymerase chain reaction]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[detectable viral charge]]></kwd>
</kwd-group>
</article-meta>
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