<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1029-3019</journal-id>
<journal-title><![CDATA[MEDISAN]]></journal-title>
<abbrev-journal-title><![CDATA[MEDISAN]]></abbrev-journal-title>
<issn>1029-3019</issn>
<publisher>
<publisher-name><![CDATA[Centro Provincial de Información de Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1029-30192022000300005</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Caracterización clinicoepidemiológica de pacientes con hemofilia congénita de tipos A y B en Santiago de Cuba]]></article-title>
<article-title xml:lang="en"><![CDATA[Clinical epidemiological characterization of patients with types A and B congenital hemophilia in Santiago de Cuba]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández Alvarez]]></surname>
<given-names><![CDATA[Haron]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital General Docente Dr. Juan Bruno Zayas Alfonso  ]]></institution>
<addr-line><![CDATA[Santiago de Cuba ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<volume>26</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1029-30192022000300005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1029-30192022000300005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1029-30192022000300005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La hemofilia es una enfermedad de origen genético, ligada al cromosoma X, que afecta la capacidad natural de la sangre para formar un coágulo, debido a la ausencia, disminución o un defectuoso funcionamiento de los factores VIII y IX, de ahí los tipos A y B, respectivamente.  Objetivo:  Describir las características clínicas y epidemiológicas de pacientes con hemofilia congénita de tipos A y B en Santiago de Cuba.  Método:  Se realizó un estudio descriptivo y transversal de los 41 pacientes con hemofilia congénita de tipos A y B (en una población pediátrica y de adultos) atendidos en la consulta de trastornos hemostáticos del Hospital General Docente Dr. Juan Bruno Zayas Alfonso de Santiago de Cuba, desde noviembre de 2017 hasta diciembre de 2018.  Resultados:  En la serie predominaron los adultos jóvenes con hemofilia A (56,1 %), la hemofilia moderada (58,6 %), la lesión articular ligera (36,6 %), el crioprecipitado como tratamiento más utilizado y el nivel de escolaridad secundario.  Conclusiones:  La hemofilia A fue la más frecuente, en adultos jóvenes residentes en el municipio de Santiago de Cuba, principalmente la de tipo moderada y con artropatía leve. No se encontraron diferencias en relación con los informes nacionales e internacionales y el estudio de las alteraciones genéticas y moleculares estuvo limitado por las condiciones tecnológicas del momento.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  The hemophilia is a disease of genetic origin, linked to chromosome X that affects the natural capacity of the blood to form a clot, due to the absence, decrease or a defective operation of the factors VIII and IX, hence the types A and B, respectively.  Objective:  To describe the clinical and epidemiologic characteristics of patients with types A and B congenital hemophilia in Santiago de Cuba.  Method:  A descriptive and cross-sectional study of the 41 patients with types A and B congenital hemophilia (in a pediatric and adults population) assisted in the hemostatic disorders service of Dr. Juan Bruno Zayas Alfonso Teaching General Hospital in Santiago de Cuba, was carried out from November, 2017 to December, 2018.  Results:  In the series there was a prevalence of young adults with hemophilia A (56.1 %), moderate hemophilia (58.6 %), light articular lesion (36.6 %), the cryoprecipitate as the most used treatment and the secondary school level.  Conclusions:  The hemophilia A was the most frequent, in young adults residents in Santiago de Cuba municipality, mainly that of moderated type and with light arthropathy. There were no differences related to the national and international reports and the study of the genetic and molecular disorders was limited by the technological conditions of the moment.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[hemofilia]]></kwd>
<kwd lng="es"><![CDATA[hemofilia A]]></kwd>
<kwd lng="es"><![CDATA[hemofilia B]]></kwd>
<kwd lng="es"><![CDATA[epidemiología]]></kwd>
<kwd lng="en"><![CDATA[hemophilia]]></kwd>
<kwd lng="en"><![CDATA[hemophilia A]]></kwd>
<kwd lng="en"><![CDATA[hemophilia B]]></kwd>
<kwd lng="en"><![CDATA[epidemiology]]></kwd>
</kwd-group>
</article-meta>
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