<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1029-3019</journal-id>
<journal-title><![CDATA[MEDISAN]]></journal-title>
<abbrev-journal-title><![CDATA[MEDISAN]]></abbrev-journal-title>
<issn>1029-3019</issn>
<publisher>
<publisher-name><![CDATA[Centro Provincial de Información de Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1029-30192023000600004</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Características microbiológicas de la enfermedad neumocócica en niños menores de 5 años de Santiago de Cuba]]></article-title>
<article-title xml:lang="en"><![CDATA[Microbiologic characteristics of the pneumococcus disease in children under 5 years from Santiago de Cuba]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Arias Portales]]></surname>
<given-names><![CDATA[Itciar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Valdés García]]></surname>
<given-names><![CDATA[Luis Eugenio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Laboratorio Provincial de Higiene, Epidemiología y Microbiología  ]]></institution>
<addr-line><![CDATA[Santiago de Cuba ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Instituto Finlay de Vacunas  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<volume>27</volume>
<numero>6</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1029-30192023000600004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1029-30192023000600004&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1029-30192023000600004&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La infección por Streptococcus pneumoniae constituye una causa importante de morbimortalidad en el mundo, sobre todo en niños menores de 5 años, en los que ocasiona de 1 a 2 millones de muertes anuales.  Objetivo:  Determinar la presencia de S. pneumoniae en muestras clínicas obtenidas en niños.  Métodos:  Se realizó un estudio descriptivo y transversal en niños menores de 5 años de edad con diagnóstico clínico de enfermedad neumocócica invasiva, asistidos en dos hospitales pediátricos de Santiago de Cuba durante el periodo 2014-2018. De las 1466 muestras clínicas tomadas y procesadas, en 131 fue aislado el agente patógeno; estas correspondieron a 59 pacientes con formas clínicas de la infección y 72 portadores. Para el procesamiento estadístico de la información se utilizaron las frecuencias absoluta y relativa como medidas de resumen.  Resultados:  En general, la positividad por S. pneumoniae fue de 8,9 %, con mayores frecuencias de aislamiento en las muestras de líquido cefalorraquídeo (81,8 %), líquido pleural (47,1 %) y exudado ótico (21,9 %), que asimismo coincidieron con los porcentajes más elevados de neumonía (61,0), otitis media aguda (23,7) y meningitis (15,3), como formas clínicas de la enfermedad neumocócica, que aquejó principalmente a niños de 1 año de edad, seguidos de los mayores de 2 años. De igual modo, se identificaron 9 serotipos de S. pneumoniae, con predominio del 19A (39,0 %), el 14 (25,4 %) y el 6A (11,9 %). En los pacientes que portaban la bacteria en la nasofaringe se identificaron 8 tipos serológicos, predominantemente el 19A y el 14. Por último, se halló una alta resistencia microbiana a la eritromicina y a la combinación trimetoprima-sulfametoxazol.  Conclusiones:  Los resultados de este estudio proporcionaron un referente científico antes de la introducción de la vacuna antineumocócica cubana, lo que permitirá evaluar su impacto en la incidencia de dicha enfermedad.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  The infection due to Streptococcus pneumoniae constitutes an important cause of morbimortality in the world, mainly in children under 5 years, that causes from 1 to 2 million annual deaths.  Objective:  To determine the presence of S. pneumoniae in clinical samples obtained in children.  Methods:  A descriptive and cross-sectional study was carried out in children under 5 years with clinical diagnosis of invasive pneumococcus disease, assisted in two children hospitals from Santiago de Cuba during the period 2014-2018. Of the 1466 clinical samples taken and processed, in 131 the pathogen agent was isolated; these corresponded to 59 patients with clinical forms of the infection and 72 carriers of the disease. For the statistical processing of the information the absolute and relative frequencies were used as summary measures.  Results:  In general the positivity for S. pneumoniae was of 8.9 %, with more isolation frequencies in the samples of cerebrospinal fluid (81.8 %), pleural fluid (47.1 %) and otic exudate (21.9 %) that also coincided with the highest percentages of pneumonia (61.0), acute otitis media (23.7) and meningitis (15.3), as clinical forms of the neumococcus disease that mainly affected 1 year children, followed by those over 2 years. In a same way, 9 serotypes of S. pneumoniae were identified, with prevalence of the 19A (39.0 %), and 14 (25.4 %) and the 6A (11.9 %). In the nasopharyngeal carriers 8 serotypes were identified, of which the 19A and 14 prevailed. Lastly, a high microbian resistance to erythromycin and the combination trimethoprim-sulfametoxazole was found.  Conclusions:  The results of this study provided a scientific referent before the introduction of the Cuban antipneumococcus vaccine that will allow to evaluate its impact in the incidence of this disease.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[enfermedad neumocócica invasiva]]></kwd>
<kwd lng="es"><![CDATA[Streptococcus pneumoniae]]></kwd>
<kwd lng="es"><![CDATA[niños]]></kwd>
<kwd lng="es"><![CDATA[otitis media]]></kwd>
<kwd lng="es"><![CDATA[meningitis]]></kwd>
<kwd lng="es"><![CDATA[neumonía]]></kwd>
<kwd lng="es"><![CDATA[vacunas antineumocócicas]]></kwd>
<kwd lng="es"><![CDATA[resistencia antimicrobiana]]></kwd>
<kwd lng="en"><![CDATA[invasive neumococcus disease]]></kwd>
<kwd lng="en"><![CDATA[Streptococcus pneumoniae]]></kwd>
<kwd lng="en"><![CDATA[children]]></kwd>
<kwd lng="en"><![CDATA[otitis media]]></kwd>
<kwd lng="en"><![CDATA[meningitis]]></kwd>
<kwd lng="en"><![CDATA[pneumonia]]></kwd>
<kwd lng="en"><![CDATA[antineumococcus vaccine]]></kwd>
<kwd lng="en"><![CDATA[antimicrobian resistance]]></kwd>
</kwd-group>
</article-meta>
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