<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1029-3019</journal-id>
<journal-title><![CDATA[MEDISAN]]></journal-title>
<abbrev-journal-title><![CDATA[MEDISAN]]></abbrev-journal-title>
<issn>1029-3019</issn>
<publisher>
<publisher-name><![CDATA[Centro Provincial de Información de Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1029-30192023000600005</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Sensibilidad ante 2 concentraciones de extractos alergénicos de ácaros]]></article-title>
<article-title xml:lang="en"><![CDATA[Sensibility considering 2 concentrations of mite allergenic extracts]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Olivera Álvarez]]></surname>
<given-names><![CDATA[Pável Benito]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Montero Naranjo]]></surname>
<given-names><![CDATA[Ada Elaine]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Gutiérrez López]]></surname>
<given-names><![CDATA[Jerjes Iván]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Reyna]]></surname>
<given-names><![CDATA[Ruby]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Figueredo Tornés]]></surname>
<given-names><![CDATA[Juan Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Policlínico Docente Ernesto Guevara de la Serna. Niquero  ]]></institution>
<addr-line><![CDATA[Granma ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2023</year>
</pub-date>
<volume>27</volume>
<numero>6</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1029-30192023000600005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1029-30192023000600005&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1029-30192023000600005&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  Los extractos alergénicos Valergen® (Dermatophagoides pteronyssinus, Blomia tropicalis y Dermatophagoides siboney), desarrollados en el Centro Nacional de Biopreparados para usarlos en pruebas cutáneas de pacientes con alergia, han demostrado altas sensibilidad y especificidad.  Objetivo:  Determinar la sensibilidad ante 2 concentraciones diferentes de extractos alergénicos de ácaros mediante pruebas cutáneas por punción.  Métodos:  Se realizó un estudio observacional, descriptivo y transversal de 230 pacientes de 5 a 49 años de edad, atendidos en el Policlínico Docente Ernesto Guevara de la Serna de Niquero, provincia de Granma, durante el 2022. Las variables analizadas fueron respuestas positivas según la edad, tipo de extractos alergénicos, sensibilización según enfermedades alérgicas, así como reacción adversa local.  Resultados:  En ambas concentraciones, la de 20 000 UB/ml y la de 2000 UB/ml, predominaron el grupo etario de 5 a 13 años (47,0 %), las respuestas positivas (27,8 y 25,7 % para cada dilución) y el extracto alergénico Dermatophagoides pteronyssinus (con 93,9 y 89,1 %, respectivamente). La rinitis fue la enfermedad alérgica con mayor sensibilización (29,1 % en la primera concentración y 28,3 % en la segunda). Los efectos adversos locales se presentaron solo en la de 20 000 UB/ml (3,9 %), con un diámetro promedio del habón de 15,9 mm (IC 95 %: 15,4 - 16,4 mm) para la reacción superior.  Conclusiones:  Los extractos alergénicos de ácaros con una concentración de 2000 UB/ml resultaron igualmente sensibles y seguros que la dilución establecida de 20 000 UB/ml, la cual es reconocida a escala nacional por su calidad como medio diagnóstico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  The Valergen® allergenic extracts (Dermatophagoides pteronyssinus, Blomia tropicalis and Dermatophagoides siboney), developed in the National Center for Biopreparations to use them in cutaneous tests to the patients with allergy, have demonstrated a high sensibility and specificity.  Objective: To determine the sensibility considering 2 different concentrations of mite allergenic extracts by means of needle cutaneous tests.  Methods: An observational, descriptive and cross-sectional study of 230 patients aged 5 to 49 was carried out. They were assisted in Ernesto Guevara de la Serna Teaching Polyclinic in Niquero, Granma province, during 2022. The analyzed variables were positive responses according to age, type of allergenic extracts, sensitization according to allergic diseases, as well as local adverse reaction.  Results:  In both concentrations, 20 000 UB/ml and 2000 UB/ml, there was a prevalence of the 5 to 13 age group (47.0%), the positive responses (27.8 and 25.7% for each dilution) and the Dermatophagoides pteronyssinus allergenic extract (93.9 and 89.1%, respectively). Rhinitis was the allergic disease with more sensitization (29.1 in the first concentration and 28.3% in the second one). The local adverse events were just presented in that of 20 000 UB/ml (3.9%) with an average wheal diameter of 15.9 mm (IC 95%: 15.4 - 16.4 mm) for the higher reaction.  Conclusions:  Mite allergenic extracts with a concentration of 2000 UB/ml were equally sensitive and safe than the established dilution of 20 000 UB/ml, which is recognized on a national scale by its quality as diagnosis method.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[pruebas cutáneas]]></kwd>
<kwd lng="es"><![CDATA[extracto alergénico]]></kwd>
<kwd lng="es"><![CDATA[concentración]]></kwd>
<kwd lng="es"><![CDATA[sensibilidad]]></kwd>
<kwd lng="en"><![CDATA[cutaneous tests]]></kwd>
<kwd lng="en"><![CDATA[allergenic extract]]></kwd>
<kwd lng="en"><![CDATA[concentration]]></kwd>
<kwd lng="en"><![CDATA[sensibility]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[González Pérez]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Durmiendo con su enemigo: Ácaros y alergia]]></article-title>
<source><![CDATA[Ars Clínica Académica]]></source>
<year>2019</year>
<volume>5</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>10-5</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bermudez Cordoví]]></surname>
<given-names><![CDATA[LL]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez Pérez]]></surname>
<given-names><![CDATA[JR]]></given-names>
</name>
<name>
<surname><![CDATA[Reyes González]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Escalona Lallana]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sensibilización a ácaros y hongos ambientales en pacientes pediátricos con asma y rinitis alérgica]]></article-title>
<source><![CDATA[Rev Electrón. "Dr. Zoilo E. Marinello Vidaurreta."]]></source>
<year>2021</year>
<volume>46</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>1-9</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pérez Reyes]]></surname>
<given-names><![CDATA[LM]]></given-names>
</name>
<name>
<surname><![CDATA[Morera Franco]]></surname>
<given-names><![CDATA[MI]]></given-names>
</name>
<name>
<surname><![CDATA[Hernández Brito]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Reactividad cutánea e inmunoterapia con ácaros Vallergen en pacientes alérgicos. Municipio Yaguajay 2014-2018]]></article-title>
<source><![CDATA[RCCS]]></source>
<year>2019</year>
<volume>4</volume>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Escalona Lallana]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Martínez Pérez]]></surname>
<given-names><![CDATA[JR]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Modificación de los resultados de la prueba cutánea de Prick después del tratamiento con inmunoterapia]]></article-title>
<source><![CDATA[Rev Electrón. "Dr. Zoilo E. Marinello Vidaurreta."]]></source>
<year>2022</year>
<volume>47</volume>
<numero>4</numero>
<issue>4</issue>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zambrano Ibarra]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pruebas cutáneas]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Agache]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
<name>
<surname><![CDATA[Alonso Lebrero]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Álvarez Perea]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[de Aramburu Mera]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Audicana Berasategui]]></surname>
<given-names><![CDATA[MT]]></given-names>
</name>
<name>
<surname><![CDATA[Baeza Ochoa de Ocáriz]]></surname>
<given-names><![CDATA[ML]]></given-names>
</name>
</person-group>
<source><![CDATA[El libro de las enfermedades alérgicas]]></source>
<year>2021</year>
<edition>2 ed</edition>
<publisher-loc><![CDATA[Bilbao ]]></publisher-loc>
<publisher-name><![CDATA[Fundación BBVA]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Rodríguez]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Labrada]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Célio]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Aboukhair]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Meli]]></surname>
<given-names><![CDATA[VR]]></given-names>
</name>
<name>
<surname><![CDATA[Barata]]></surname>
<given-names><![CDATA[HJ]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Comparación de la potencia de extractos alergénicos de ácaros en pacientes con asma y rinitis alérgica]]></article-title>
<source><![CDATA[VacciMonitor]]></source>
<year>2012</year>
<volume>21</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>25-9</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Perdomo Pulido]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[González Marín]]></surname>
<given-names><![CDATA[AT]]></given-names>
</name>
<name>
<surname><![CDATA[González Iglesias]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Morales Valdés]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[González Iglesias]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sensibilización cutánea en pacientes alérgicos, utilizando extractos de ácaros Valergen]]></article-title>
<source><![CDATA[Gac Méd Espirit]]></source>
<year>2020</year>
<volume>22</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>81-9</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Toribio Pájaro]]></surname>
<given-names><![CDATA[EC]]></given-names>
</name>
<name>
<surname><![CDATA[García Asensi]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez Santos]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Rinitis alérgica, apnea-hipopnea obstructiva del sueño y sensibilización a ácaros]]></article-title>
<source><![CDATA[VacciMonitor]]></source>
<year>2022</year>
<volume>31</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>120-6</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Inguillay Chacha]]></surname>
<given-names><![CDATA[GL]]></given-names>
</name>
<name>
<surname><![CDATA[Gagñay Angamarca]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
</person-group>
<source><![CDATA[Método de Prick-test en la etiología de la rinitis alérgica infantil. Centro Asma-Alergias Muñoz, 2018]]></source>
<year>2019</year>
<publisher-loc><![CDATA[Riobamba ]]></publisher-loc>
<publisher-name><![CDATA[Universidad Nacional de Chimborazo]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Villavicencio Varas]]></surname>
<given-names><![CDATA[JP]]></given-names>
</name>
</person-group>
<source><![CDATA[Importancia de la determinación de las reacciones cruzadas en las pruebas diagnósticas para alergias por Dermatophagoides pteronyssinus, farinae y microceras]]></source>
<year>2020</year>
<publisher-loc><![CDATA[Quito ]]></publisher-loc>
<publisher-name><![CDATA[Universidad Central del Ecuador]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[González Pérez]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Pineda]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Poza Guedes]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Castillo]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Matheu]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez Machín]]></surname>
<given-names><![CDATA[I]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Molecular Allergen Profiling of Dual Mite Sensitization in Severe Allergic Rhinitis]]></article-title>
<source><![CDATA[J Investig Allergol Clin Immunol]]></source>
<year>2020</year>
<volume>30</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>421-9</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[González Pérez]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Poza Guedes]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Pineda]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Castillo]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Depiction of Major Mite Allergens in Severe Allergic Rhinitis with High Mite Perennial Exposure]]></article-title>
<source><![CDATA[Turk. Arch. Otorhinolaryngol]]></source>
<year>2020</year>
<volume>58</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>155-62</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sánchez]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Cardona]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Diferencias clínicas entre niños con asma y rinitis de áreas rurales y urbanas]]></article-title>
<source><![CDATA[Colomb Med]]></source>
<year>2018</year>
<volume>49</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>169-74</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Montes Ángel]]></surname>
<given-names><![CDATA[IA]]></given-names>
</name>
<name>
<surname><![CDATA[López González]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Torres Concepción]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Álvarez Castelló]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Castro Almarales]]></surname>
<given-names><![CDATA[RL]]></given-names>
</name>
<name>
<surname><![CDATA[Rodríguez Canosa]]></surname>
<given-names><![CDATA[JS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Caracterización de la rinitis alérgica en el Hospital Universitario "General Calixto García". Octubre 2016-Octubre 2017]]></article-title>
<source><![CDATA[VacciMonitor]]></source>
<year>2020</year>
<volume>29</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>75-81</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Díaz Rodríguez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Fabré Ortiz]]></surname>
<given-names><![CDATA[DE]]></given-names>
</name>
<name>
<surname><![CDATA[Coutin Marie]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Gonzáles Méndez]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Sensibilización a ácaros Relación con enfermedades atópicas en escolares de San Antonio de los Baños]]></article-title>
<source><![CDATA[Rev Alerg Mex]]></source>
<year>2009</year>
<volume>56</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>80-5</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sánchez]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Sánchez]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Cardona]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Preguntas comunes en alergias. Enfoque práctico para el diagnóstico y manejo en atención primaria]]></article-title>
<source><![CDATA[Rev Alerg Mex]]></source>
<year>2018</year>
<volume>65</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>197-207</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Matos Benavides]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[García Gomero]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Inocente Malpartida]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pruebas de apoyo al diagnóstico en enfermedades alérgicas]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Aguilar Olano]]></surname>
<given-names><![CDATA[JL]]></given-names>
</name>
</person-group>
<source><![CDATA[Bases de la inmunología clínica]]></source>
<year>2019</year>
<edition>2 ed</edition>
<publisher-loc><![CDATA[Lima ]]></publisher-loc>
<publisher-name><![CDATA[Universidad Peruana Cayetano Heredia]]></publisher-name>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
