<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1029-3043</journal-id>
<journal-title><![CDATA[Medicentro Electrónica]]></journal-title>
<abbrev-journal-title><![CDATA[Medicentro Electrónica]]></abbrev-journal-title>
<issn>1029-3043</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de Villa Clara]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1029-30432021000200265</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Relación entre el diagnóstico precoz y la mortalidad por sepsis: nuevos conceptos]]></article-title>
<article-title xml:lang="en"><![CDATA[Relationship between early diagnosis and mortality due to sepsis: new concepts]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Merlán Martínez]]></surname>
<given-names><![CDATA[Mabel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ferrer Aguilar]]></surname>
<given-names><![CDATA[Eliety]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Morel]]></surname>
<given-names><![CDATA[Miriam]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Universitario Clínico-Quirúrgico Arnaldo Milián Castro  ]]></institution>
<addr-line><![CDATA[Santa Clara Villa Clara]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas de Villa Clara  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2021</year>
</pub-date>
<volume>25</volume>
<numero>2</numero>
<fpage>265</fpage>
<lpage>290</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1029-30432021000200265&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1029-30432021000200265&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1029-30432021000200265&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  la sepsis es la respuesta desregulada del organismo ante una infección. Se reconoce por un conjunto de manifestaciones: clínicas, hemodinámicas, hematológicas, bioquímicas e inflamatorias, las cuales forman parte de una respuesta orgánica global. Se trata de una enfermedad compleja y controvertida en cuanto a: su clasificación, epidemiología, presentación, diagnóstico y tratamiento. Constituye una de las afecciones más frecuentes en los hospitales y especialmente en las UCI. Varios estudios epidemiológicos recientes demuestran que su incidencia aumenta, y que ha superado a otras enfermedades como: el ictus, el cáncer o el infarto de miocardio, ya que, además de generar un importante consumo de recursos, presenta una elevada mortalidad, que en el caso del shock séptico puede alcanzar cifras cercanas al 50 %.  Objetivo:  realizar una revisión de la evidencia disponible sobre la relación entre el diagnóstico precoz y la mortalidad por sepsis.  Métodos: s e realizó una búsqueda sistemática de publicaciones en las bases de datos Medline, PubMed, y Elsevier; se utilizaron los términos: sepsis, shock séptico, sepsis grave y citoquinas.  Resultados:  para la redacción de este artículo se seleccionaron 42 publicaciones, de un total de 111. Todos los documentos fueron revisados y se escogieron los que resultaron transcendentales para entender las características fisiopatológicas y la evolución de la sepsis; se destacó el papel fundamental del diagnóstico precoz y su relación con la mortalidad.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: sepsis is the unregulated response of the body to an infection. It is recognized by a set of clinical, hemodynamic, hematological, biochemical and inflammatory manifestations, which are part of a global organic response. It is a complex and controversial disease in terms of its classification, epidemiology, presentation, diagnosis and treatment. It is one of the most frequent conditions in hospitals and especially in ICUs. Several recent epidemiological studies show that its incidence increases, and that it has exceeded other diseases such as stroke, cancer or myocardial infarction, since, in addition to generate a significant consumption of resources, it presents a high mortality, which in the case of septic shock can reach figures close to 50%.  Objective: to conduct a review of the available evidence on the relationship between early diagnosis and mortality due to sepsis.  Methods: a systematic search of publications was carried out in Medline, PubMed, and Elsevier databases; the terms sepsis, septic shock, severe sepsis, and cytokines were used.  Results:  42 publications from a total of 111 were selected to write this article. All documents were reviewed and those that were transcendental were chosen for understanding the physiopathological characteristics and evolution of sepsis; the fundamental role of early diagnosis and its relationship with mortality was highlighted.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[diagnóstico precoz]]></kwd>
<kwd lng="es"><![CDATA[infección hospitalaria/epidemiología]]></kwd>
<kwd lng="en"><![CDATA[early diagnosis]]></kwd>
<kwd lng="en"><![CDATA[cross infection/epidemiology]]></kwd>
</kwd-group>
</article-meta>
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<name>
<surname><![CDATA[Ferrer]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Artigas]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Levy]]></surname>
<given-names><![CDATA[MM]]></given-names>
</name>
<name>
<surname><![CDATA[Blanco]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[González-Díaz]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Garnacho-Montero]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Edusepsis Study Group. Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain]]></article-title>
<source><![CDATA[JAMA]]></source>
<year>2008</year>
<volume>299</volume>
<numero>19</numero>
<issue>19</issue>
<page-range>2294-303</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
