<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1029-3043</journal-id>
<journal-title><![CDATA[Medicentro Electrónica]]></journal-title>
<abbrev-journal-title><![CDATA[Medicentro Electrónica]]></abbrev-journal-title>
<issn>1029-3043</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de Villa Clara]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1029-30432023000200010</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Factores genéticos y ambientales asociados al fenotipo longevo]]></article-title>
<article-title xml:lang="en"><![CDATA[Genetic and environmental factors associated with the longevity phenotype]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández Caraballo]]></surname>
<given-names><![CDATA[Douglas]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Heredia Ruiz]]></surname>
<given-names><![CDATA[Danay]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Herrera Martínez]]></surname>
<given-names><![CDATA[Manuela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Chaviano Machado]]></surname>
<given-names><![CDATA[Sonia Yanet]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Yanetsy García]]></surname>
<given-names><![CDATA[Yisel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Villa Clara Unidad de Investigaciones Biomédicas ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas de Villa Clara  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Centro Provincial de Genética  ]]></institution>
<addr-line><![CDATA[ Villa Clara]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2023</year>
</pub-date>
<volume>27</volume>
<numero>2</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1029-30432023000200010&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1029-30432023000200010&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1029-30432023000200010&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: La prevalencia de la longevidad en la población abierta ha aumentado en los últimos cien años. Existen coincidencias en la literatura sobre la importancia de varios factores relacionados con el estilo de vida como elementos favorecedores de la longevidad.  Objetivo: Demostrar la influencia de factores genéticos y ambientales en el fenotipo longevo.  Métodos: Se estudiaron 178 individuos provenientes del municipio Santa Clara: 86 longevos de 80 años y más, y 92 no longevos (menores de 80 años). A todos se les aplicó un instrumento de recogida de información genealógica sobre antecedentes de longevidad y factores genéticos y ambientales favorecedores. Para los análisis de asociación se procedió a la confección de tablas de contingencia tetracóricas. Se evaluó la asociación mediante la prueba Ji cuadrado de Mantel-Haenszel, así como V de Cramer para medir la magnitud de asociación; cuando el nivel de significación fue p&lt;0,05, se calculó la oportunidad relativa y el intervalo de confianza al 95 %.  Resultados: Las asociaciones resultaron significativas para las siguientes variables: no hábito de fumar, no beber alcohol, tener índice de masa corporal normopeso, no padecer enfermedades respiratorias, tener madre longeva, y ser del sexo femenino. Las razones de ventajas más elevadas se alcanzaron en dos factores: no padecer de enfermedades respiratorias y no beber alcohol. La asociación más fuerte fue con la longevidad de la madre (V Cramer=0,234).  Conclusiones: Los factores genéticos y ambientales que, de manera consistente, se asociaron a la longevidad, indicaron que en los individuos estudiados existen factores favorecedores de la longevidad.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  prevalence of longevity in open population has increased in the last hundred years. There are coincidences in the literature on the importance of various factors related to lifestyle as elements that favour longevity.  Objective: to demonstrate the influence of genetic and environmental factors on the longevity phenotype.  Methods: 178 individuals from Santa Clara municipality were studied: 86 longevous people aged 80 years and over and 92 non-longevous ones aged less than 80 years. An instrument for collecting genealogical information on longevity antecedents and favorable genetic and environmental factors was applied to all of them. Tetrachoric contingency tables were prepared for the association analysis. This association was evaluated using the Mantel-Haenszel chi-square test, as well as the Cramer's V test to measure the magnitude of association; an odds ratio and a 95% confidence interval were calculated when the significance level was p&lt;0.05.  Results: the associations were significant for the following variables: not-smoking and not-drinking alcohol, not suffering from respiratory diseases, having a normal weight body mass index and a longevous mother, as well as being female. The highest odds ratios were achieved in two factors: not suffering from respiratory diseases and not drinking alcohol. The strongest association was with maternal longevity (V Cramer=0.234).  Conclusions: the genetic and environmental factors that were consistently associated with longevity indicated that there are factors that favour longevity in the studied individuals.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[longevidad]]></kwd>
<kwd lng="es"><![CDATA[envejecimiento]]></kwd>
<kwd lng="es"><![CDATA[adulto mayor]]></kwd>
<kwd lng="en"><![CDATA[longevity]]></kwd>
<kwd lng="en"><![CDATA[aging]]></kwd>
<kwd lng="en"><![CDATA[elderly]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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