<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1560-4381</journal-id>
<journal-title><![CDATA[Correo Científico Médico]]></journal-title>
<abbrev-journal-title><![CDATA[ccm]]></abbrev-journal-title>
<issn>1560-4381</issn>
<publisher>
<publisher-name><![CDATA[Universidad Ciencias Médicas de Holguín]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1560-43812019000200599</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Ataxias cerebelosas hereditarias: principales avances neurofisiológicos, clínicos y genéticos]]></article-title>
<article-title xml:lang="en"><![CDATA[Main neurophysiological, clinical and genetics advances on Hereditary cerebellar ataxias]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Pupo]]></surname>
<given-names><![CDATA[Jorge Michel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Núñez Arias]]></surname>
<given-names><![CDATA[Enriqueta]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rojas Rodríguez]]></surname>
<given-names><![CDATA[Yesenia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aguilera Sánchez]]></surname>
<given-names><![CDATA[Yolaine]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Amieiro Paz]]></surname>
<given-names><![CDATA[Myrurgia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sarmiento Oliveros]]></surname>
<given-names><![CDATA[Martha Aleida]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Clínico-Quirúrgico Lucía Iñiguez Landín  ]]></institution>
<addr-line><![CDATA[Holguín ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Pediátrico Octavio de la Concepción de la Pedraja  ]]></institution>
<addr-line><![CDATA[Holguín ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Ciencias Médicas  ]]></institution>
<addr-line><![CDATA[Holguín ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2019</year>
</pub-date>
<volume>23</volume>
<numero>2</numero>
<fpage>599</fpage>
<lpage>622</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1560-43812019000200599&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1560-43812019000200599&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1560-43812019000200599&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El término ataxias cerebelosas hereditarias comprende un amplio espectro de trastornos neurológicos en los cuales la ataxia es el síntoma principal. Conforman un complejo grupo de entidades cuyo reconocimiento es esencial para el correcto asesoramiento genético, el adecuado control clínico y, en algunos casos, el apropiado abordaje terapéutico. La riqueza clínico-semiológica y los avances en la biología molecular han convertido a las ataxias hereditarias en uno de los temas más apasionantes de la neurología.   El diagnóstico clínico de los subtipos de ataxias es complicado, por la prominente superposición de fenotipos entre los subtipos genéticos. En este artículo abordamos los principales avances neurofisiológicos, clínicos y genéticos de las ataxias cerebelosas hereditarias.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT The term &#8220;Hereditary cerebellar ataxia&#8221; comprises a wide spectrum of neurological disorders where ataxia is the main symptom. Hereditary ataxias are a complex group of entities, in which detection is essential for an adequate genetic assessment, satisfactory clinical control and in some cases, a suitable therapeutic approach. Clinical semiology variety and molecular biology advanceshave become hereditary ataxias one of the most interesting subjects inside neurology. Subtypes clinical diagnosis of ataxias is complicated by the salient overlap of phenotypes between genetic subtypes. In this article, we refer to the most important neurophysiological, clinical and genetics advances of hereditary cerebellar ataxias.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[ataxias cerebelosas hereditarias]]></kwd>
<kwd lng="es"><![CDATA[asesoramiento genético]]></kwd>
<kwd lng="es"><![CDATA[biología molecular]]></kwd>
<kwd lng="es"><![CDATA[fenotipos]]></kwd>
<kwd lng="en"><![CDATA[hereditary cerebellar ataxias]]></kwd>
<kwd lng="en"><![CDATA[genetic assessment]]></kwd>
<kwd lng="en"><![CDATA[molecular biology]]></kwd>
<kwd lng="en"><![CDATA[phenotypes]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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