<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1560-4381</journal-id>
<journal-title><![CDATA[Correo Científico Médico]]></journal-title>
<abbrev-journal-title><![CDATA[ccm]]></abbrev-journal-title>
<issn>1560-4381</issn>
<publisher>
<publisher-name><![CDATA[Universidad Ciencias Médicas de Holguín]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1560-43812020000200702</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Nuevos enfoques terapéuticos de las dislipidemias]]></article-title>
<article-title xml:lang="en"><![CDATA[New therapeutic approaches to dyslipidemias]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ojeda Armas]]></surname>
<given-names><![CDATA[Iliana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Expósito Lara]]></surname>
<given-names><![CDATA[Alexander]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Benítez]]></surname>
<given-names><![CDATA[Sonia Noemí]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Freire Maridueña]]></surname>
<given-names><![CDATA[Elsa Narcisa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Campoverde Bravo]]></surname>
<given-names><![CDATA[Javier Antonio]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Escuela Superior Politécnica de Chimborazo  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Coordinación Provincial de Prestaciones de Seguro de Salud Guayas  ]]></institution>
<addr-line><![CDATA[Guayas ]]></addr-line>
<country>Ecuador</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<volume>24</volume>
<numero>2</numero>
<fpage>702</fpage>
<lpage>722</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1560-43812020000200702&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1560-43812020000200702&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1560-43812020000200702&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN La dislipidemia es un factor de riesgo importante modificable de enfermedad cardiovascular por aterosclerosis. Se realizó una revisión bibliográfica con los descriptores dislipidemia y tratamiento, en inglés y español, en PubMed, PubMed Central, SciELO y Clinical Key. Se enfatizó sobre las nuevas modalidades terapéuticas aprobadas o en desarrollo que actúan principalmente sobre las dianas moleculares: paraproteína convertasa subtilisina/kexina tipo 9 (PCSK9), proteína transferidora de ésteres de colesterol (CETP), proteína semejante a angiopoyetina 3 (ANGPTL3), receptor activado por proliferador de peroxisoma alfa (PPAR&#945;), acetil-CoA carboxilasa, citrato ATP liasa, diacilglicerol aciltransferasa, apo A1, apo C-III, apo (a) y proteína microsomal de transferencia de triglicéridos (MTP). Las modalidades terapéuticas fundamentales fueron los anticuerpos monoclonales (alirocumab y evolocumab), los oligonucleótidos sin sentido (inclisiran, volanesorsen), las vacunas, la edición del genoma, los inhibidores enzimáticos (gemcabeno, prodigastat) y los suplementos nutricionales (omega 3).]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Dyslipidemia is a major modifiable risk factor for cardiovascular disease due to atherosclerosis. A literature review was conducted with the descriptors dyslipidemia and treatment, in English and Spanish, in PubMed, PubMed Central, SciELO and Clinical Key. Emphasis was placed on new therapeutic modalities approved or under development that act mainly on molecular targets: subtilisin/kexin type 9 paraprotein converter (PCSK9), cholesterol ester transfer protein (CETP), angiopoietin-like protein 3 (ANGPTL3), receptor activated by peroxisome alpha proliferator (PPAR&#945;), acetyl-CoA carboxylase, ATP citrate lyase, diacylglycerol acyltransferase, apo A1, apo C-III, apo (a) and microsomal triglyceride transfer protein (MTP). The key therapeutic modalities were monoclonal antibodies (alirocumab and evolocumab), no-sense oligonucleotides (inclisiran, volanesorsen), vaccines, genome editing, enzyme inhibitors (gemcaben, prodigastat) and nutritional supplements (omega 3).]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[dislipidemias]]></kwd>
<kwd lng="es"><![CDATA[hipercolesterolemia]]></kwd>
<kwd lng="es"><![CDATA[hipertrigliceridemia]]></kwd>
<kwd lng="es"><![CDATA[HDL-colesterol bajo]]></kwd>
<kwd lng="es"><![CDATA[enfermedad cardiovascular]]></kwd>
<kwd lng="es"><![CDATA[prevención]]></kwd>
<kwd lng="es"><![CDATA[tratamiento hipolipemiante]]></kwd>
<kwd lng="en"><![CDATA[dyslipidemias]]></kwd>
<kwd lng="en"><![CDATA[hypercholesterolemia]]></kwd>
<kwd lng="en"><![CDATA[hypertriglyceridemia]]></kwd>
<kwd lng="en"><![CDATA[low HDL-cholesterol]]></kwd>
<kwd lng="en"><![CDATA[cardiovascular disease]]></kwd>
<kwd lng="en"><![CDATA[prevention]]></kwd>
<kwd lng="en"><![CDATA[lipid-lowering therapy]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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