<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1561-3003</journal-id>
<journal-title><![CDATA[Revista Cubana de Higiene y Epidemiología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Hig Epidemiol]]></abbrev-journal-title>
<issn>1561-3003</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias MédicasEditorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1561-30032022000100003</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Primeros pasos en la inmunoprofilaxis contra la leptospirosis en Cuba]]></article-title>
<article-title xml:lang="en"><![CDATA[First steps towards immunoprophylaxis against leptospirosis in Cuba]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Abreu Ugarte]]></surname>
<given-names><![CDATA[Jorge Eduardo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
<xref ref-type="aff" rid="Aaf"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de las Fuerzas Armadas Revolucionarias  ]]></institution>
<addr-line><![CDATA[ La Habana]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2022</year>
</pub-date>
<volume>59</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1561-30032022000100003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1561-30032022000100003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1561-30032022000100003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  La leptospirosis es una zoonosis de distribución mundial. En la década de los años 70 del pasado siglo xx aumentó la incidencia en Cuba, principalmente en trabajadores agrícolas. En Camagüey se produjo un brote que llevó a establecer el Programa Nacional de Control de la Leptospirosis Humana, puesto en vigor por los Ministerios de Salud Pública y la Agricultura. En 1982 investigadores de la Dirección Nacional de Zoonosis realizaron un ensayo clínico para evaluar inmunogenicidad y reactogenicidad de una vacuna antileptospirósica humana del Instituto de Sueros y Vacunas de Stávropol.  Objetivo:  Reconstruir los primeros pasos en la inmunoprofilaxis contra la leptospirosis en Cuba.  Métodos: Se utilizó el método historiográfico. Los datos se obtuvieron en las bases de datos: Infomed, Dialnet, Medigraphic, Medline y Scielo.  Análisis y síntesis de la información: Las recomendaciones de la investigación plantearon aplicar la vacuna a grupos de riesgo y producir una vacuna con cepas autóctonas de leptospiras. El análisis de la bibliografía consultada de las últimas cuatro décadas corrobora el cumplimiento de las recomendaciones.  Conclusiones: Hace cuarenta años científicos cubanos realizaron los estudios iniciales sobre inmunogenicidad y reactogenicidad de una vacuna procedente de la pretérita Unión Soviética. Las recomendaciones de la investigación se cumplieron. Se realizó la vacunación a grupos de riesgo en la población, principalmente trabajadores agrícolas y se logró una vacuna con cepas autóctonas de leptospiras. Los datos expuestos sobre los primeros pasos en la inmunoprofilaxis contra la leptospirosis en Cuba tienen relevancia para la historiografía médica por los aportes a la salud pública, prioridad del Estado cubano.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Leptospirosis is a zoonosis of worldwide distribution. In the 1970s, there was an increase in the incidence of this disease in Cuba, mainly among agricultural workers. An outbreak in Camagüey led to the establishment of the National Program for the Control of Human Leptospirosis adopted by the Ministries of Public Health and Agricultures. In 1982, a clinical trial was conducted to evaluate the immunogenicity and the reactogenicity of a vaccine against human leptospirosis from the Institute of Vaccines and Sera of Stavropol.  Objective:  To retrace the first steps towards immunoprophylaxis against leptospirosis in Cuba.  Methods: The historiographic method was used. Data were retrieved from the following databases: Infomed, Dialnet, Medigraphic, Medline and SciELO.  Analysis and synthesis of the information:  Recommendations from the research suggested administering the vaccine to risk groups, and producing a vaccine from autochthonous Leptospira strains. The analysis of the consulted bibliography from the last four decades corroborates the fulfillment of these recommendations.  Conclusions:  Forty years ago, Cuban scientists conducted the first studies on immunogenicity and reactogenicity of a vaccine from the former Soviet Union. The recommendations derived from the research were fulfilled. Population groups at risk, mainly agricultural workers, were vaccinated, and a vaccine from autochthonous Leptospira strains was obtained. Given the contributions to public health, which is a priority of the Cuban government, data presented on the first steps towards immunoprophylaxis against leptospirosis in Cuba are of paramount importance for the medical historiography.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[inmunoprofilaxis]]></kwd>
<kwd lng="es"><![CDATA[vacuna]]></kwd>
<kwd lng="es"><![CDATA[leptospira]]></kwd>
<kwd lng="es"><![CDATA[leptospirosis]]></kwd>
<kwd lng="es"><![CDATA[zoonosis]]></kwd>
<kwd lng="es"><![CDATA[ensayo clínico]]></kwd>
<kwd lng="en"><![CDATA[immunoprophylaxis]]></kwd>
<kwd lng="en"><![CDATA[vaccine]]></kwd>
<kwd lng="en"><![CDATA[Leptospira]]></kwd>
<kwd lng="en"><![CDATA[leptospirosis]]></kwd>
<kwd lng="en"><![CDATA[zoonosis]]></kwd>
<kwd lng="en"><![CDATA[clinical trial]]></kwd>
</kwd-group>
</article-meta>
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