<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1561-3003</journal-id>
<journal-title><![CDATA[Revista Cubana de Higiene y Epidemiología]]></journal-title>
<abbrev-journal-title><![CDATA[Rev. cuba. hig. epidemiol.]]></abbrev-journal-title>
<issn>1561-3003</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias MédicasEditorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1561-30032023000100008</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Reanálisis del estudio de Carlos J. Finlay acerca del mosquito como vector de la fiebre amarilla]]></article-title>
<article-title xml:lang="en"><![CDATA[A Fresh look at Carlos J. Finlay's Study on the Mosquito as a Vector of Yellow Fever]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ballesteros]]></surname>
<given-names><![CDATA[Javier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad del País Vasco Facultad de Medicina y Enfermería Departamento de Neurociencias]]></institution>
<addr-line><![CDATA[ Leioa]]></addr-line>
<country>Spain</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>60</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1561-30032023000100008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1561-30032023000100008&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1561-30032023000100008&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  El primer registro de la asociación causal entre el mosquito Aedes aegypti, y la transmisión de la fiebre amarilla, lo constituyó la comunicación presentada por Carlos J. Finlay a la Academia de Ciencias de La Habana en 1881. El científico cubano mostró los resultados de la inoculación, por picadura de mosquito infectado, en cinco sujetos de un conjunto de 20 personas sanas.  Objetivo:  Reanalizar la evidencia mediante la aplicación de técnicas estadísticas aún no desarrolladas en tiempo del científico cubano, y evaluar la fortaleza de la evidencia causal.  Métodos:  Los resultados se analizaron mediante el test exacto de Fisher, el factor de Bayes y la diferencia de riesgos, el riesgo relativo y el odds ratio de la asociación. Se valoró la fortaleza de la evidencia de la asociación causal mediante criterio estadístico sin desconocer los criterios de causalidad más actualizados.  Resultados:  El test exacto de Fisher fue altamente significativo (p= 0,009), y el factor de Bayes (24,9) resultó compatible con una evidencia fuerte a favor de la asociación entre la inoculación y el desarrollo de la enfermedad. También apoyaron la asociación, la diferencia de riesgos (0,55; IC 95 %: 0,15-0,96), el riesgo relativo (18,7; IC 95 %: 1,12-3-10,3) y el odds ratio (43,4; IC 95 %: 1,68-11-19,7).  Conclusiones:  Los resultados de Finlay resultaron robustos, y se ajustaron a los criterios de causalidad para explicar la transmisión de la fiebre amarilla por el mosquito.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  The first record of the causal association between the Aedes aegypti mosquito and the transmission of yellow fever was the communication submitted by Carlos J. Finlay to the Havana Academy of Sciences in 1881. The Cuban scientist showed the results of inoculation, by infected mosquito bite, in five subjects from a group of 20 healthy people.  Objective:  To revise the evidence through the use of statistical techniques not yet developed at the time of the Cuban scientist and to evaluate the strength of the causal evidence.  Methods:  Results were analyzed using Fisher's exact test, Bayes factor, and risk difference, relative risk, and odds ratio of association. The strength of the evidence of the causal association was assessed using statistical criteria minding the most up-to-date causality criteria.  Results:  Fisher's exact test was highly significant (p = 0.009), and the Bayes factor (24.9) was compatible with strong evidence in favor of the association between inoculation and disease development. The association was also supported by the risk difference (0.55; 95% CI: 0.15-0.96), the relative risk (18.7; 95% CI: 1.12-310.3), and the odds ratio (43.4; 95% CI: 1.68-1119.7).  Conclusions:  Finlay's results were robust, and adjusted to the causality criteria to explain the transmission of yellow fever by mosquitoes.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Carlos J Finlay]]></kwd>
<kwd lng="es"><![CDATA[fiebre amarilla]]></kwd>
<kwd lng="es"><![CDATA[mosquito.]]></kwd>
<kwd lng="en"><![CDATA[Carlos J Finlay]]></kwd>
<kwd lng="en"><![CDATA[yellow fever]]></kwd>
<kwd lng="en"><![CDATA[mosquito]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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