<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1561-3194</journal-id>
<journal-title><![CDATA[Revista de Ciencias Médicas de Pinar del Río]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ciencias Médicas]]></abbrev-journal-title>
<issn>1561-3194</issn>
<publisher>
<publisher-name><![CDATA[Editorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1561-31942019000400542</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Morfometría de corazón y pulmón en ratas Wistar infectadas con leptospira canícola durante la preñez]]></article-title>
<article-title xml:lang="en"><![CDATA[Heart and lung morphometry in Wistar rats infected with canine leptospira during pregnancy]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Monzón Tamargo]]></surname>
<given-names><![CDATA[María de Jesús]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Peterssen Sánchez]]></surname>
<given-names><![CDATA[Manuel Guillermo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez Cardoso]]></surname>
<given-names><![CDATA[Javier Joaquín]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González García]]></surname>
<given-names><![CDATA[Xiomara]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Freije]]></surname>
<given-names><![CDATA[Susana]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Pinar del Río  ]]></institution>
<addr-line><![CDATA[Pinar del Río ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Dirección Municipal de Salud  ]]></institution>
<addr-line><![CDATA[Pinar del Río ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Ciencias Médicas de Pinar del Río Clínica Estomatológica Docente Ormani Arenado Llonch ]]></institution>
<addr-line><![CDATA[Pinar del Río ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<volume>23</volume>
<numero>4</numero>
<fpage>542</fpage>
<lpage>552</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1561-31942019000400542&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1561-31942019000400542&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1561-31942019000400542&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: la leptospirosis es una zoonosis de amplia distribución mundial que ocasiona grandes pérdidas a la salud del hombre.  Objetivo: determinar las alteraciones morfométricas de corazón y pulmón en ratas Wistar infectadas con leptospira canícola durante la preñez.  Métodos: estudio descriptivo, observacional y transversal, en el Laboratorio de Investigaciones Biomédicas de la Universidad de Ciencias Médicas de Pinar del Río, desde septiembre 2016 hasta agosto 2018, en 120 crías de ratas Wistar posterior al sacrificio, cuyas madres, durante la gestación fueron inoculadas con cepas del serogrupoleptospira canícula. Se estudiaron las variables: sexo, peso, volumen de corazón y pulmones, longitud transversa, longitud sagital, y grosor del ventrículo izquierdo. Se realizó examen morfométrico con la utilización del software MOTIC, y la digitalización de las imágenes con una cámara MOTIC-AM 3 acoplada a un estereoscopio, ambos conectados a un ordenador para la recogida y análisis de los datos.  Resultados: predominaron los machos con un 55,84 %, donde se observó en ambos sexos, disminución del peso y volumen del corazón. El promedio morfométrico de la longitud transversa, longitud sagital, y el grosor del ventrículo izquierdo del corazón disminuyó sus longitudes. No existieron diferencias en ambos sexos en relación al peso y volumen de ambos pulmones.  Conclusiones: resultados similares, sin evaluar otros daños, pueden ocurrir en el hombre cuando se infecta con leptospirosis. Se debe incentivar el desarrollo de investigaciones donde se utilicen otras cepas de leptospiras, que permitan evaluar y evitar defectos en el desarrollo humano.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  leptospirosis is a zoonosis of wide-ranging distribution worldwide that causes great losses to human health.  Objective:  to determine the morphometric changes of heart and lung in Wistar rats infected with canine leptospira during pregnancy.  Methods:  descriptive, observational and cross-sectional study carried out at Pinar del Río University of Medical Sciences, mainly by the Biomedical Research Laboratory, from September 2016 to August 2018, on 120 offspring of Wistar rats posterior to the slaughter, whose mothers, during gestation, were inoculated with strains of the canicula serogroup leptospira. The following variables were included in the study: sex, weight, heart and lung volume, crosswise length, sagittal length, and left ventricle thickness. Morphometric examination was performed with the use of MOTIC software and digitalization of the images with a MOTIC-AM 3 camera coupled to a stereoscope, both connected to a computer for data collection and analysis.  Results:  male sex predominated with 55.84%, where a decrease in weight and heart volume was observed in both genders. The morphometric average of crosswise length, sagittal length and the thickness of the left ventricle of the heart decreased its lengths. There were no differences in both sexes in relation to the weight and volume of both lungs.  Conclusions:  similar results, without evaluating other damages, can occur in men when infected with leptospirosis. The development of researches where other strains of leptospira can be used should be encouraged, in order to evaluate and avoid defects in human development.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[LEPTOSPIRA]]></kwd>
<kwd lng="es"><![CDATA[RATAS WISTAR]]></kwd>
<kwd lng="es"><![CDATA[SEROGRUPO]]></kwd>
<kwd lng="es"><![CDATA[ZOONOSIS]]></kwd>
<kwd lng="es"><![CDATA[LEPTOSPIROSIS]]></kwd>
<kwd lng="en"><![CDATA[LEPTOSPIRA]]></kwd>
<kwd lng="en"><![CDATA[RATS, WISTAR]]></kwd>
<kwd lng="en"><![CDATA[SEROGROUP]]></kwd>
<kwd lng="en"><![CDATA[ZOONOSES]]></kwd>
<kwd lng="en"><![CDATA[LEPTOSPIROSIS]]></kwd>
</kwd-group>
</article-meta>
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