<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1561-3194</journal-id>
<journal-title><![CDATA[Revista de Ciencias Médicas de Pinar del Río]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ciencias Médicas]]></abbrev-journal-title>
<issn>1561-3194</issn>
<publisher>
<publisher-name><![CDATA[Editorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1561-31942019000500745</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Fundamentos fisiopatológicos para el diagnóstico de la anemia hemolítica autoinmune]]></article-title>
<article-title xml:lang="en"><![CDATA[Pathophysiological basics for the diagnosis of autoimmune hemolytic anemia]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández González]]></surname>
<given-names><![CDATA[Jorge Luis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fortún Prieto]]></surname>
<given-names><![CDATA[Adalberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Campo Díaz]]></surname>
<given-names><![CDATA[Mirta Caridad]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Pinar del Río. Hospital Pediátrico Provincial Docente Pepe Portilla ]]></institution>
<addr-line><![CDATA[Pinar del Río ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas de Pinar del Río Hospital Clínico Quirúrgico Docente Dr. León Cuervo Rubio ]]></institution>
<addr-line><![CDATA[Pinar del Río Cuba]]></addr-line>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2019</year>
</pub-date>
<volume>23</volume>
<numero>5</numero>
<fpage>745</fpage>
<lpage>757</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1561-31942019000500745&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1561-31942019000500745&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1561-31942019000500745&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  la anemia hemolítica autoinmune es producida por anticuerpos que reaccionan con los eritrocitos propios del paciente, demostrables a través de la positividad del test de antiglobulina o prueba de Coombs directa. La clasificación de la enfermedad se basa en dos parámetros fundamentales: su etiología y las características térmicas del funcionamiento de los autoanticuerpos.  Objetivo:  actualizar la información científica sobre las causas y la fisiopatología de la anemia hemolítica autoinmune.  Métodos:  se realizó una revisión de los principales libros de texto y los artículos más recientes publicados en las principales revistas hematológicas e inmunológicas, para lograr una guía práctica del diagnóstico de la enfermedad.  Discusión:  debido a que existe una amplia gama de protocolos para su diagnóstico basados en parámetros no siempre coincidentes, se expone una metodología para el trabajo de los médicos que atienden enfermos con diferentes tipos de anemia hemolítica autoinmune, sobre la base de los conocimientos acerca de las causas y la fisiopatología de la enfermedad.  Conclusiones:  la comprensión de la fisiopatología y los criterios de clasificación de la anemia hemolítica autoinmune es un requisito para el diagnóstico de este trastorno, y la utilización de las nuevas opciones terapéuticas en el manejo de estos enfermos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  autoimmune hemolytic anemia is produced by antibodies that react with the patient's own erythrocytes provable through the positivity of the antiglobulin test or direct Coombs test. The classification of the disease is based on two fundamental parameters: its etiology and the thermal characteristics of the functioning of the auto antibodies accounts.  Objective:  to update scientific information on the causes and pathophysiological autoimmune hemolytic anemia.  Methods:  a review of the main textbooks and the most recent articles published in the main hematological and immunological journals was carried out, bringing together the knowledge to achieve a practical guide to the diagnosis of this disease.  Discussion:  due to the fact that there is a wide range of protocols for its diagnosis, based on parameters that do not always coincide, a methodology is presented for the work of physicians who treat patients with different types of autoimmune hemolytic anemia based on knowledge about the causes and the pathophysiological characteristics of this disease.  Conclusions:  understanding the physiopathology and classification criteria of autoimmune hemolytic anemia is a requirement for the diagnosis of this disorder and the use of new therapeutic options in the management of these patients.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[ANEMIA HEMOLÍTICA AUTOINMUNE/fisiopatología]]></kwd>
<kwd lng="es"><![CDATA[CLASIFICACIÓN]]></kwd>
<kwd lng="es"><![CDATA[DIAGNÓSTICO]]></kwd>
<kwd lng="es"><![CDATA[AUTOANTICUERPOS]]></kwd>
<kwd lng="es"><![CDATA[AUTOANTÍGENOS]]></kwd>
<kwd lng="en"><![CDATA[ANEMIA, HERMOLYTIC AUTOIMMUNE/physiopathology]]></kwd>
<kwd lng="en"><![CDATA[CLASSIFICATION]]></kwd>
<kwd lng="en"><![CDATA[DIAGNOSIS]]></kwd>
<kwd lng="en"><![CDATA[AUTOANTIBODIES]]></kwd>
<kwd lng="en"><![CDATA[AUTOANTIGENS]]></kwd>
</kwd-group>
</article-meta>
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