<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1561-3194</journal-id>
<journal-title><![CDATA[Revista de Ciencias Médicas de Pinar del Río]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ciencias Médicas]]></abbrev-journal-title>
<issn>1561-3194</issn>
<publisher>
<publisher-name><![CDATA[Editorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1561-31942020000300009</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Cambios en variables hematológicas y velocidad de sedimentación globular de pacientes no críticos con la COVID-19]]></article-title>
<article-title xml:lang="en"><![CDATA[Changes in hematological variables and globular sedimentation rate in non-critical patients withCOVID-19]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Fajardo]]></surname>
<given-names><![CDATA[Ivette]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Linares Guerra]]></surname>
<given-names><![CDATA[Elisa Maritza]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz Padilla]]></surname>
<given-names><![CDATA[Dianelys]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Godoy Lóriga]]></surname>
<given-names><![CDATA[Lilliana Maris]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Núñez Betancourt]]></surname>
<given-names><![CDATA[Amaury]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Provincial Docente Clínico Quirúrgico Dr. León Cuervo Rubio  ]]></institution>
<addr-line><![CDATA[Pinar del Río ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Pinar del Río Hermanos Saíz Montes de Oca  ]]></institution>
<addr-line><![CDATA[Pinar del Río ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Hospital Clínico Quirúrgico Abel Santamaría Cuadrado  ]]></institution>
<addr-line><![CDATA[Pinar del Río ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2020</year>
</pub-date>
<volume>24</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1561-31942020000300009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1561-31942020000300009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1561-31942020000300009&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: las pruebas de hematología clínica y la velocidad de sedimentación globular (VSG) se han utilizado como marcadores de evolución clínica en pacientes con la COVID-19.  Objetivo: analizar los cambios de variables hematológicas y VSG en pacientes diagnosticados con la COVID-19 en estado no crítico, ingresados en el Hospital Provincial Docente Clínico Quirúrgico Dr. &#8220;León Cuervo Rubio&#8221; de Pinar del Río, entre el 16 de marzo y el 4 de mayo de 2020.  Métodos:  se realizó un estudio observacional analítico y longitudinal prospectivo con datos de 44 pacientes no críticos con la COVID-19. Se examinaron muestras de: hemoglobina, hematocrito, conteo global de leucocitos, neutrófilos, linfocitos, células de tamaño medio y la eritrosedimentación; al ingreso, a las 48 h, al octavo día y al egreso. Se analizaron los cambios longitudinales de dichas variables por medio de la prueba no paramétrica de Friedman para k muestras relacionadas.  Resultados:  las variables hematológicas: hemoglobina, hematocrito, conteo global de leucocitos, neutrófilos y linfocitos no tuvieron modificaciones significativas durante el seguimiento. Solo las células de tamaño medio disminuyeron significativamente en los niños, al comparar su valor medio al egreso con relación al ingreso (p=0,028) y al segundo día de hospitalización (p=0,01). En los pacientes masculinos adultos, la VSG disminuyó significativamente al octavo día y al alta médica, con relación a su valor al ingreso (p=0,008).  Conclusiones:  los cambios observados en las variables hematológicas evaluadas, especialmente el de las células de tamaño medio en niños, y eritrosedimentación en hombres con la COVID-19 en estado no crítico, responden a una evolución clínica favorable.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  clinical hematology tests and globular sedimentation rate (ESR) have been used as markers of clinical evolution in patients with thenovel coronavirus disease 2019.  Objective:  to analyze changes in hematological variables and ESR in patients diagnosed with COVID-19 in non-critical status, admitted to Dr. León Cuervo Rubio Provincial Clinical-surgical Teaching Hospital, between March 16 and May 4, 2020.  Methods:  an observational-analytical and longitudinal-prospective study conducted with data from 44 non-critical patients with COVID-19. Samples were examined for: hemoglobin, hematocrit, global leukocyte count, neutrophils, lymphocytes, medium size cells and erythrocyte sedimentation rate; on admission, at 48hours of admission, on the eighth day and on medical discharge. The longitudinal changes of these variables were analyzed by means of the non-parametric Friedman test for k-related samples.  Results:  hematological variables: hemoglobin, hematocrit, global leukocyte count, neutrophils and lymphocytes did not have significant changes during the follow up. Only medium size cells decreased significantly in children, when comparing their mean value at discharge in relation to admission (p=0,028) and on the second day of hospitalization (p=0,01). In adult male patients, the ESR significantly decreased at eighth day of admission and at medical discharge, in relation to its value at admission (p=0,008).  Conclusions: the changes observed in the hematological variables assessed, especially in the medium size cellsin children, and erythrocyte sedimentation rate in men with COVID-19 in non-critical status, respond to a favorable clinical evolution.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="es"><![CDATA[FACTORES EPIDEMIOLÓGICOS]]></kwd>
<kwd lng="es"><![CDATA[PACIENTE]]></kwd>
<kwd lng="es"><![CDATA[HEMATOLOGÍA]]></kwd>
<kwd lng="es"><![CDATA[PRUEBA DE LABORATORIO]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[EPIDEMIOLOGIC FACTORS]]></kwd>
<kwd lng="en"><![CDATA[PATIENT]]></kwd>
<kwd lng="en"><![CDATA[HEMATOLOGY]]></kwd>
<kwd lng="en"><![CDATA[LABORATORY TEST]]></kwd>
</kwd-group>
</article-meta>
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