<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1561-3194</journal-id>
<journal-title><![CDATA[Revista de Ciencias Médicas de Pinar del Río]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ciencias Médicas]]></abbrev-journal-title>
<issn>1561-3194</issn>
<publisher>
<publisher-name><![CDATA[Editorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1561-31942020000400009</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Validación de cuestionario sobre interacción de factores genéticos y ambientales en la aparición del asma bronquial]]></article-title>
<article-title xml:lang="en"><![CDATA[Validation of a questionnaire on the interaction of genetic and environmental factors in the development of bronchial asthma]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Orraca Castillo]]></surname>
<given-names><![CDATA[Odalys]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Lardoeyt Ferrer]]></surname>
<given-names><![CDATA[Roberto]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Orraca Castillo]]></surname>
<given-names><![CDATA[Miladys]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Pinar del Río Facultad de Ciencias Médicas Dr. Ernesto Che Guevara de la Serna ]]></institution>
<addr-line><![CDATA[Pinar del Río ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas de La Habana Facultad Finlay-Albarrán ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Servicios Médicos Cubanos  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2020</year>
</pub-date>
<volume>24</volume>
<numero>4</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1561-31942020000400009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1561-31942020000400009&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1561-31942020000400009&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: el asma bronquial es la clásica enfermedad dentro de las afecciones alérgicas, y tiene gran impacto en la salud mundial. Es una enfermedad compleja tanto genética como fenotípicamente, y las interacciones genética-ambientales la complejizan aún más.  Objetivo:  validar un cuestionario para el estudio de los factores genéticos y su interacción con factores ambientales en la aparición de los trastornos inmunitarios por asma bronquial.  Métodos: el estudio se generó en el departamento de Inmunología del Hospital Pediátrico Provincial Docente Pepe Portilla de la provincia Pinar del Río. Se seleccionó el grupo coordinador de la técnica a realizar. Se utilizó la Metodología Delphi, en sus cuatro fases: definición del tema, selección de expertos, ejecución de rondas de consultas y evaluación de los resultados. Para determinar las similitudes y concordancias de las respuestas, se calculó el coeficiente de concordancia de Kendall y Friedman.  Resultados: se seleccionaron 21 expertos con altos niveles de competencia de acuerdo al cálculo de los coeficientes de conocimiento y argumentación. En la tercera versión del cuestionario existió similitud en las respuestas de los expertos a favor de la categoría superior de Muy imprescindible, así como concordancia en el nivel de respuesta.  Conclusiones:  el cuestionario diseñado alcanza niveles óptimos de validez de contenido y factibilidad para determinar la contribución de los factores genéticos y su interacción con factores ambientales en la aparición de los trastornos inmunitarios por asma bronquial.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  bronchial asthma is the classic disease among allergic conditions, and has great impact on health worldwide. It is a complex disease both genetically and phenotypically, and genetic-environmental interactions make it even more complex.  Objective:  to validate a questionnaire for the study of the involvement of genetic factors and their interaction with environmental factors in the onset of immune disorders due to bronchial asthma.  Methods:  the study was developed in the Department of Immunology at Pepe Portilla Provincial Pediatric Teaching Hospital in Pinar del Río province. The coordinating group of the technique to be carried out was selected and comprised three professionals responsible for the proposed research. The Delphi Methodology was used, completing its four phases: definition of the topic, selection of experts, implementation of consultation rounds and assessment of results. To determine the agreement or similarities of the responses of the evaluators respectively, the Kendall and Friedman concordance coefficient was calculated.  Results:  twenty-one (21) experts with high levels of competence were selected according to the calculation of the coefficients of knowledge and argumentation. In the third version of the questionnaire, there was similarity in the responses of the experts in favor of the higher category of Very Essential, as well as agreement in the level of response of the experts.  Conclusions:  the designed questionnaire reaches optimal levels of content validity and feasibility to determine the contribution of genetic factors and their interaction with environmental factors on the onset of immune disorders due to bronchial asthma.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[ASMA BRONQUIAL]]></kwd>
<kwd lng="es"><![CDATA[EPIGÉNESIS GENÉTICA]]></kwd>
<kwd lng="es"><![CDATA[ENFERMEDADES DEL SISTEMA INMUNE]]></kwd>
<kwd lng="es"><![CDATA[VALIDACIÓN]]></kwd>
<kwd lng="en"><![CDATA[ASTHMA]]></kwd>
<kwd lng="en"><![CDATA[EPIGENESIS, GENETIC]]></kwd>
<kwd lng="en"><![CDATA[IMMUNE SYSTEM DISEASES]]></kwd>
<kwd lng="en"><![CDATA[VALIDATION]]></kwd>
</kwd-group>
</article-meta>
</front><back>
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