<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1561-3194</journal-id>
<journal-title><![CDATA[Revista de Ciencias Médicas de Pinar del Río]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ciencias Médicas]]></abbrev-journal-title>
<issn>1561-3194</issn>
<publisher>
<publisher-name><![CDATA[Editorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1561-31942020000500018</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Único paciente grave reportado con COVID-19 en Pinar del Río]]></article-title>
<article-title xml:lang="en"><![CDATA[The only severely-ill COVID-19 patient reported in Pinar del Río]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cuello Carballo]]></surname>
<given-names><![CDATA[Martha Beatriz]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz Alfonso]]></surname>
<given-names><![CDATA[Humbelina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ordoñez Alvarez]]></surname>
<given-names><![CDATA[Lázaro Yoan]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Pinar del Río Hospital Provincial Clínico Quirúrgico Docente Dr. León Cuervo Rubio ]]></institution>
<addr-line><![CDATA[Pinar del Río ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas de Pinar del Río Policlínico Universitario Hermanos Cruz ]]></institution>
<addr-line><![CDATA[Pinar del Río ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2020</year>
</pub-date>
<volume>24</volume>
<numero>5</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1561-31942020000500018&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1561-31942020000500018&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1561-31942020000500018&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  la COVID-19 causada por el SARS-CoV-2 constituye una amenaza para la salud pública mundial; con mayor efecto negativo en pacientes con comorbilidades y deterioro del estado de salud.  Caso clínico: paciente femenina, de color de piel blanca, de 59 años de edad con antecedentes patológicos personales de hipertensión arterial, diabetes mellitus tipo II, enfermedad pulmonar obstructiva crónica y exfumadora con confirmación de COVID-19 por PCR-RT, presentó neumopatía aguda inflamatoria como complicación y evolución satisfactoria. Sin fuente de infección precisada, se aislaron todos los contactos, se estudiaron y fueron negativos a la COVID-19.  Conclusiones:  se concluye con la presentación de este caso que la pandemia actual significa un desafío para la comunidad científica porque no existe un tratamiento específico contra el SARSCoV-2. No obstante, Cuba utiliza en su protocolo diversos medicamentos que han demostrado efectividad en el control de la enfermedad al lograr la evolución clínica satisfactoria de varios casos críticos.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  SARS-CoV-2 (COVID-19) is a threat to global public health; with the most negative effect on patients with comorbidities and weak health status.  Clinical case:  a 59-year-old, white skinned, female patient with personal pathological history of high blood pressure, diabetes mellitus type II, chronic obstructive pulmonary disease and ex-smoker with confirmed positive PCR-RT (COVID-19 carrier), presented acute inflammatory pneumopathy as a complication and satisfactory evolution. Without a precise source of infection, all contacts were isolated, they underwent to studies and resulted negative to COVID-19.  Conclusions:  with this case report it is concluded that this pandemic is a challenge for the scientific community because there is not a specific treatment against SARSCoV-2. Nevertheless, Cuba makes use of its protocols of treatment where diverse medicines are included; which have demonstrated effectiveness in the control of the disease, achieving a satisfactory clinical evolution of several critical patients.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[COVID-19]]></kwd>
<kwd lng="es"><![CDATA[TRANSMISIÓN DE ENFERMEDAD INFECCIOSA]]></kwd>
<kwd lng="es"><![CDATA[FACTORES EPIDEMIOLÓGICOS]]></kwd>
<kwd lng="es"><![CDATA[PACIENTE]]></kwd>
<kwd lng="es"><![CDATA[HEMATOLOGÍA]]></kwd>
<kwd lng="es"><![CDATA[PRUEBA DE LABORATORIO]]></kwd>
<kwd lng="es"><![CDATA[VENTILACIÓN MECÁNICA]]></kwd>
<kwd lng="es"><![CDATA[TRAQUEOTOMÍA]]></kwd>
<kwd lng="es"><![CDATA[UNIDAD DE CUIDADOS INTENSIVOS]]></kwd>
<kwd lng="es"><![CDATA[OXIGENOTERAPIA]]></kwd>
<kwd lng="en"><![CDATA[COVID-19]]></kwd>
<kwd lng="en"><![CDATA[DISEASE TRANSMISSION, INFECTIOUS]]></kwd>
<kwd lng="en"><![CDATA[EPIDEMIOLOGIC FACTORS]]></kwd>
<kwd lng="en"><![CDATA[PATIENTS]]></kwd>
<kwd lng="en"><![CDATA[HEMATOLOGY]]></kwd>
<kwd lng="en"><![CDATA[LABORATORY TEST]]></kwd>
<kwd lng="en"><![CDATA[RESPIRATION, ARTIFICIAL]]></kwd>
<kwd lng="en"><![CDATA[TRACHEOTOMY]]></kwd>
<kwd lng="en"><![CDATA[INTENSIVE CARE UNITS]]></kwd>
<kwd lng="en"><![CDATA[OXYGEN INHALATION THERAPY]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="book">
<source><![CDATA[statement regarding cluster of pneumonia cases in Wuhan]]></source>
<year>2020</year>
<publisher-loc><![CDATA[China ]]></publisher-loc>
<publisher-name><![CDATA[World Health Organization. WHO]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="book">
<source><![CDATA[Parte del cierre del 19 de mayo a las 12 de la noche]]></source>
<year>2020</year>
<publisher-loc><![CDATA[La Habana ]]></publisher-loc>
<publisher-name><![CDATA[Ministerio de Salud Pública]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="book">
<source><![CDATA[Actualización epidemiológica. Nuevo coronavirus (2019-nCoV)]]></source>
<year>2020</year>
<publisher-loc><![CDATA[La Habana ]]></publisher-loc>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias Médicas]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pérez Abreu]]></surname>
<given-names><![CDATA[MR]]></given-names>
</name>
<name>
<surname><![CDATA[Gómez Tejeda]]></surname>
<given-names><![CDATA[JJ]]></given-names>
</name>
<name>
<surname><![CDATA[Diéguez Guach]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Características clínico-epidemiológicas de la COVID-19]]></article-title>
<source><![CDATA[Rev haban cienc méd]]></source>
<year>2020</year>
<volume>19</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>3254</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Chih Cheng]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease2019 (COVID-19): The epidemic and the challenges]]></article-title>
<source><![CDATA[International Journal of Antimicrobial Agents]]></source>
<year>2020</year>
<volume>55</volume>
<numero>3</numero>
<issue>3</issue>
</nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="book">
<source><![CDATA[Protocolo Nacional MINSAP vs COVID-19]]></source>
<year>2020</year>
<publisher-loc><![CDATA[La Habana ]]></publisher-loc>
<publisher-name><![CDATA[Ministerio de Salud Pública]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cortegiani]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Ingoglia]]></surname>
<given-names><![CDATA[MI]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19.]]></article-title>
<source><![CDATA[Journal of Critical Care]]></source>
<year>2020</year>
<volume>57</volume>
<page-range>279-83</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Coutard]]></surname>
<given-names><![CDATA[B.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The spike glycoprotein of the new coronavirus 2019-nCoV contains a furinlike cleavage site absent in CoV of the same clade]]></article-title>
<source><![CDATA[Antiviral Research]]></source>
<year>2020</year>
<volume>176</volume>
</nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cao]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Wen]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A trial of lopinavir-ritonavir in adults hospitalized with severe COVID-19]]></article-title>
<source><![CDATA[N Engl J Med]]></source>
<year>2020</year>
<volume>382</volume>
<page-range>1787-99</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Gautret]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Lagier]]></surname>
<given-names><![CDATA[JC]]></given-names>
</name>
<name>
<surname><![CDATA[Parola]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non randomized clinical trial]]></article-title>
<source><![CDATA[Int J Antimicrob Agents]]></source>
<year>2020</year>
<volume>56</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Sanders]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Monogue]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Jodlowski]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A review]]></article-title>
<source><![CDATA[JAMA]]></source>
<year>2020</year>
<volume>323</volume>
<numero>18</numero>
<issue>18</issue>
<page-range>1824-36</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Huang]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China]]></article-title>
<source><![CDATA[The Lancet]]></source>
<year>2020</year>
<volume>395</volume>
<numero>10223</numero>
<issue>10223</issue>
<page-range>497-506</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
