<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1561-3194</journal-id>
<journal-title><![CDATA[Revista de Ciencias Médicas de Pinar del Río]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ciencias Médicas]]></abbrev-journal-title>
<issn>1561-3194</issn>
<publisher>
<publisher-name><![CDATA[Editorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1561-31942021000100007</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Coexistencia de dismorfias faciales y malformaciones congénitas en fetos humanos]]></article-title>
<article-title xml:lang="en"><![CDATA[Coexistence of facial dysmorphia and congenital malformations in human fetuses]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Zaldivar Garit]]></surname>
<given-names><![CDATA[Isvel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Linares Guerra]]></surname>
<given-names><![CDATA[Elisa Maritza]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Licourt Otero]]></surname>
<given-names><![CDATA[Deysi]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Díaz del Pino]]></surname>
<given-names><![CDATA[Rafaela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[León García]]></surname>
<given-names><![CDATA[Mileidys]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Pinar del Río Facultad de Ciencias Médicas &#8220;Dr. Ernesto Guevara de la Serna&#8221; ]]></institution>
<addr-line><![CDATA[Pinar del Río ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Pinar del Río &#8220;Hermanos Sainz Montes de Oca&#8221;.  ]]></institution>
<addr-line><![CDATA[Pinar del Río ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Ciencias Médicas de Pinar del Río Centro Provincial de Genética Médica ]]></institution>
<addr-line><![CDATA[Pinar del Río ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>02</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>02</month>
<year>2021</year>
</pub-date>
<volume>25</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1561-31942021000100007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1561-31942021000100007&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1561-31942021000100007&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: el dismorfismo facial es un tema abordado desde múltiples aristas. Las coexistencias de estos y otras afectaciones del cuerpo humano pueden tener su explicación en los procesos que ocurren durante la formación del embrión.  Objetivo: determinar la relación entre el dismorfismo facial y malformaciones congénitas presentes en sistemas de órganos, en fetos humanos.  Métodos: se realizó una investigación observacional analítica y transversal a 42 fetos humanos producto de interrupciones de embarazo. Se realizó durante la autopsia medición de estructuras faciales. Se tuvo en cuenta perfil facial, simetría, existencia de hipoplasias faciales y malformaciones congénitas en diferentes sistemas de órganos.  Resultados: se observó un 66,7 % de fetos masculinos, la edad materna promedio fue de 29,3 ± 7,5 años. Las dismorfias del perfil facial (73,8 %), la región frontal (57,1 %) y la mandíbula (54,7 %) fueron más frecuentes. Solo las malformaciones cardiovasculares mostraron una correlación positiva, significativa con los signos dismórficos faciales (p=0,006; R=0,414).  Conclusiones: el dismorfismo facial de fetos humanos se relacionó con las malformaciones del sistema cardiovascular. Esto resultados pueden ser útiles en el diagnóstico precoz de los defectos congénitos del corazón.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  facial dysmorphia is a topic approached from multiple angles. The coexistence of these and other disorders of the human body can be explained by the processes that occur during the development of the embryo.  Objective:  to determine the relationship between facial dysmorphia and congenital malformations present in the system of organs in human fetuses.  Methods:  an analytical, cross-sectional, observational research was carried out on 42 human fetuses resulting from pregnancy interruptions. During the autopsy, facial structures were measured. Facial profile, symmetry, existence of facial hypoplasias and congenital malformations in different system of organs were considered.  Results:  66,7 % of male fetuses were observed, average maternal age was 29,3 ± 7,5 years. Dysmorphia of the facial profile (73,8 %), the frontal region (57,1 %) and the jaw (54,7 %) were more frequent. Only cardiovascular malformations showed a positive, significant correlation with signs of facial dysmorphia (p=0,006; R=0,414).  Conclusions:  facial dysmorphia in human fetuses was related to malformations of the cardiovascular system, which could be useful in the early diagnosis of congenital heart defects.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[CARDIOPATÍA]]></kwd>
<kwd lng="es"><![CDATA[ANOMALÍAS CONGÉNITAS]]></kwd>
<kwd lng="es"><![CDATA[FETO]]></kwd>
<kwd lng="es"><![CDATA[MICROGNATISMO]]></kwd>
<kwd lng="es"><![CDATA[RETROGNATISMO]]></kwd>
<kwd lng="en"><![CDATA[HEART DISEASES]]></kwd>
<kwd lng="en"><![CDATA[CONGENITAL ABNORMALITIES]]></kwd>
<kwd lng="en"><![CDATA[FETUS]]></kwd>
<kwd lng="en"><![CDATA[MICROGNATHISM]]></kwd>
<kwd lng="en"><![CDATA[RETROGNATHIA]]></kwd>
</kwd-group>
</article-meta>
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