<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1561-3194</journal-id>
<journal-title><![CDATA[Revista de Ciencias Médicas de Pinar del Río]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ciencias Médicas]]></abbrev-journal-title>
<issn>1561-3194</issn>
<publisher>
<publisher-name><![CDATA[Editorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1561-31942022000300023</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Enfermedad de Crohn fistulizante en una adolescente]]></article-title>
<article-title xml:lang="en"><![CDATA[Fistulizing Crohn's disease in an adolescent girl: a case report]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González-Álvarez]]></surname>
<given-names><![CDATA[José Ridal]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez-Ramírez]]></surname>
<given-names><![CDATA[Emilio Andrés]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ruiz-Santiago]]></surname>
<given-names><![CDATA[Ernesto René]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martín-Ruiz]]></surname>
<given-names><![CDATA[Adisnuvia]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Pinar del Río. Hospital Pediátrico Provincial Docente Pepe Portilla ]]></institution>
<addr-line><![CDATA[Pinar del Río ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad de Ciencias Médicas de Pinar del Río Hospital General Docente Abel Santamaría Cuadrado ]]></institution>
<addr-line><![CDATA[Pinar del Río. ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<volume>26</volume>
<numero>3</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1561-31942022000300023&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1561-31942022000300023&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1561-31942022000300023&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  la enfermedad de Crohn es una enfermedad inflamatoria intestinal de causa desconocida con una génesis multifactorial que afectan todo el tracto digestivo, desde la boca hasta el ano.  Presentación de caso:  se describe un caso de una adolescente de 18 años de edad con historia de múltiples ingresos hospitalarios por cuadros de fiebre, diarreas, cólicos abdominales y desnutrición proteico energética que a los nueve años se le hace diagnóstico de una colitis ulcerosa, con una respuesta no favorable al tratamiento con salazosufalpiridina, mesalazina, esteroides orales e inmunosupresores. A los 16 años de edad presenta fisuras y fistulas perianales. Por la histología se concluye que es enfermedad de Crohn; fue necesario la realización de ileostomía y tratamiento con anticuerpos monoclonales (infliximab), primera experiencia de su uso en Pinar del Río.  Conclusiones:  presentó una respuesta muy favorable con cicatrización total de las fisuras y las fístulas perianales, desarrollo de caracteres sexuales secundarios, así como su menarquia y recuperación nutricional.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: Crohn's disease is an inflammatory bowel disease of unknown cause with a multifactorial genesis affecting the entire digestive tract, from the mouth to the anus.  Case report: an 18-year-old adolescent girl with a history of multiple hospital admissions for fever, diarrhea, abdominal colic and protein-energy malnutrition. At the age of 9 she was diagnosed with ulcerative colitis, with an unfavorable response to treatment with salicylazosulfapyridine, mesalazine, oral steroids and immunosuppressant. At 16 years old she presented fissures and perianal fistulas, histologically concluded as Crohn's disease, and it was necessary to perform an ileostomy and treatment with monoclonal antibodies (infliximab), the first experience of its use in the province.  Conclusions: she presented a very favorable response with total healing of the fissures and perianal fistulas, development of secondary sexual characteristics as well as her menarche and nutritional recovery.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[ENFERMEDAD DE CROHN]]></kwd>
<kwd lng="es"><![CDATA[INFLIXIMAB]]></kwd>
<kwd lng="es"><![CDATA[TRACTO GASTROINTESTINAL]]></kwd>
<kwd lng="en"><![CDATA[CROHN DISEASE]]></kwd>
<kwd lng="en"><![CDATA[INFLIXIMAB]]></kwd>
<kwd lng="en"><![CDATA[GASTROINTESTINAL TRACT]]></kwd>
</kwd-group>
</article-meta>
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