<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1561-3194</journal-id>
<journal-title><![CDATA[Revista de Ciencias Médicas de Pinar del Río]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ciencias Médicas]]></abbrev-journal-title>
<issn>1561-3194</issn>
<publisher>
<publisher-name><![CDATA[Editorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1561-31942022000600015</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Cardiopatías congénitas en fetos humanos con defectos extra cardiacos]]></article-title>
<article-title xml:lang="en"><![CDATA[Congenital heart defects in human fetuses with extra cardiac defects]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Garit]]></surname>
<given-names><![CDATA[Isvel Zaldivar]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sanchez]]></surname>
<given-names><![CDATA[Madelyn Guerra]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Ordaz]]></surname>
<given-names><![CDATA[Aimee Lucía Carbó]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Domínguez]]></surname>
<given-names><![CDATA[Milay Arteaga]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández]]></surname>
<given-names><![CDATA[Dianelys Nuñez]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hernández]]></surname>
<given-names><![CDATA[Yamila Velázquez]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Pinar del Río Facultad de Ciencias Médicas &#8220;Dr. Ernesto Guevara de la Serna&#8221; ]]></institution>
<addr-line><![CDATA[Pinar del Río ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>12</month>
<year>2022</year>
</pub-date>
<volume>26</volume>
<numero>6</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1561-31942022000600015&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1561-31942022000600015&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1561-31942022000600015&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: las malformaciones cardiacas son los defectos congénitos más frecuentes en los seres humanos. Estas son alteraciones estructurales y funcionales del corazón, del sistema circulatorio y de los grandes vasos, que se desarrollan durante la embriogénesis cardiaca. Estos defectos repercuten en la calidad de vida de los pacientes y familiares, conocer mejor estos defectos permite su prevención, diagnóstico y tratamiento.  Objetivo: identificar la asociación entre las cardiopatías congénitas y los defectos extra cardiacos, en fetos humanos.  Métodos: se realizó una investigación observacional analítica y transversal en fetos humanos obtenidos a partir de interrupciones de embarazo realizadas por indicación de Genética Médica entre enero del 2019 y mayo del 2020 en Pinar del Río, Cuba. La muestra estuvo representada por 42 fetos, seleccionados a través de un muestreo no probabilístico de tipo intencional. La información se obtuvo de los informes de autopsias y las solicitudes de interrupción, a los datos obtenidos se les aplicaron estadística descriptiva e inferencial.  Resultados: en el estudio se observó que la mayor parte de los fetos estudiados eran del sexo masculino; la comunicación interventricular fue el defecto cardiovascular más frecuente y que entre los defectos extra cardiacos, los de mayor incidencia fueron los del sistema Osteomioarticular, mostrando estos defectos una asociación significativa a la Comunicación interventricular.  Conclusiones: en los fetos humanos, los defectos del sistema osteomioarticular se asocian a malformaciones cardiovasculares específicas.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ ABSTRACT  Introduction:  cardiac malformations are the most frequent congenital defects in humans. These are structural and functional alterations of the heart, circulatory system and great vessels that develop during cardiac embryogenesis. These defects have an impact on the quality of life of patients and their families, and a better understanding of these defects allows their prevention, diagnosis and treatment.  Objective:  to identify the association between congenital heart disease and extracardiac defects in human fetuses.  Methods:  an analytical and cross-sectional observational research was carried out in human fetuses obtained from pregnancy terminations performed by indication of Medical Genetics between January 2019 and May 2020 in Pinar del Rio, Cuba. The sample was represented by 42 fetuses, selected through a non-probabilistic purposive sampling. The information was obtained from autopsy reports and requests for termination. Descriptive and inferential statistics were applied to the data obtained.  Results:  the study showed that most of the fetuses studied were male; ventricular septal defect was the most frequent cardiovascular defect and that among the extracardiac defects, those with the highest incidence were those of the osteomyoarticular system, showing a significant association with ventricular septal defect.  Conclusions:  in human fetuses, osteomyoarticular system defects are associated with specific cardiovascular malformations.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[CARDIOPATÍA CONGÉNITA]]></kwd>
<kwd lng="es"><![CDATA[MALFORMACIÓN CONGÉNITA]]></kwd>
<kwd lng="es"><![CDATA[FETO]]></kwd>
<kwd lng="es"><![CDATA[CORAZÓN]]></kwd>
<kwd lng="en"><![CDATA[HEART DEFECTS]]></kwd>
<kwd lng="en"><![CDATA[CONGENITAL]]></kwd>
<kwd lng="en"><![CDATA[SKIN ABNORMALITIES]]></kwd>
<kwd lng="en"><![CDATA[FETUS]]></kwd>
<kwd lng="en"><![CDATA[HEART]]></kwd>
</kwd-group>
</article-meta>
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