<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1561-3194</journal-id>
<journal-title><![CDATA[Revista de Ciencias Médicas de Pinar del Río]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ciencias Médicas]]></abbrev-journal-title>
<issn>1561-3194</issn>
<publisher>
<publisher-name><![CDATA[Editorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1561-31942023000400003</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Caracterización de pacientes con Virus de Inmunodeficiencia Humana positivos a criptococosis meníngea diagnosticados por estudio de líquido cefalorraquídeo en el Hospital Regional Docente De Ambato]]></article-title>
<article-title xml:lang="en"><![CDATA[Characterization of patients with Human Immunodeficiency Virus positive for meningeal cryptococcosis diagnosed by cerebrospinal fluid study at Regional Teaching Hospital of Ambato]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Santamaria Acosta]]></surname>
<given-names><![CDATA[Christian Alexander]]></given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Wong Vásquez]]></surname>
<given-names><![CDATA[Lester]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Labrada González]]></surname>
<given-names><![CDATA[Elsy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Regional Autónoma de Los Andes  ]]></institution>
<addr-line><![CDATA[Ambato ]]></addr-line>
<country>Ecuador</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>27</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1561-31942023000400003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1561-31942023000400003&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1561-31942023000400003&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: el Virus de Inmunodeficiencia Humana constituye un problema de salud a escala global, que propicia en los pacientes el desarrollo de infecciones oportunistas.  Objetivo: caracterizar a los pacientes con Virus de Inmunodeficiencia Humana positivos a criptococosis meníngea.  Métodos: estudio observacional, descriptivo, transversal en pacientes con el Virus de Inmunodeficiencia Humana positivos a criptococosis meníngea diagnosticado por estudio de líquido cefalorraquídeo en el Hospital Regional Docente de Ambato en el periodo 2018-2021. La muestra (n=155) se seleccionó por un muestreo aleatorio simple.  Resultados: predominó el sexo masculino (78,7 %) y las edades entre 31 y 40 años (36,1 %); la principal sintomatología fue la cefalea (69 %), fiebre (42,6 %) y nauseas (31 %). El 22,6 % de los pacientes no se adhería a los antirretrovirales, el 23,2 % presentó conteo de CD4 &lt; 500/mm3 y el 43,9 % consumía drogas. El 51,6 % de los pacientes presentaron valores superiores a 100 mg/ dL proteínas, el 51 % inferiores a los 29 mg/ dL de glucosa en líquido cefalorraquídeo. Las alteraciones de las proteínas mostraron asociación con los niveles de CD4 (p&lt;0,01) y la carga viral (p&lt;0,05).  Conclusiones: los pacientes con Virus de Inmunodeficiencia Humana del sexo masculino, en edades entre la tercera y cuarta década de vida, que no se adhieren a la terapia antirretroviral y/o consumen drogas son propensos al desarrollo de criptococosis meníngea. El análisis citoquímico del líquido cefalorraquídeo resulta útil como biomarcador de pronósticos desfavorables en pacientes con criptococosis meníngea.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Introduction: Human Immunodeficiency Virus is a global health problem, which leads to the development of opportunistic infections in patients. Objective: to characterize patients with Human Immunodeficiency Virus positive for meningeal cryptococcosis. Methods: observational, descriptive, cross-sectional study in patients with Human Immunodeficiency Virus positive to meningeal cryptococcosis diagnosed by cerebrospinal fluid study in the Regional Teaching Hospital of Ambato in the period 2018-2021. The sample (n=155) was selected by simple random sampling. Results: male sex (78,7 %) and ages between 31 and 40 years (36,1 %) predominated; the main symptomatology was headache (69 %), fever (42,6 %) and nausea (31 %). 22,6 % of the patients were not adherent to antiretrovirals, 23,2 % had CD4 count &lt; 500/mm3 and 43,9 % were drug users. Of the patients, 51,6 % had values higher than 100 mg/ dL protein, 51 % had values lower than 29 mg/ dL glucose in cerebrospinal fluid. Protein alterations were associated with CD4 levels (p&lt;0.01) and viral load (p&lt;0,05). Conclusions: patients with Human Immunodeficiency Virus of male sex, aged between the third and fourth decade of life, who do not adhere to antiretroviral therapy and/or consume drugs are prone to the development of meningeal cryptococcosis. Cytochemical analysis of cerebrospinal fluid is useful as a biomarker of unfavorable prognosis in patients with meningeal cryptococcosis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[VIH]]></kwd>
<kwd lng="es"><![CDATA[CRIPTOCOCOSIS]]></kwd>
<kwd lng="es"><![CDATA[LÍQUIDO CEFALORRAQUÍDEO]]></kwd>
<kwd lng="es"><![CDATA[INFECCIONES OPORTUNISTAS]]></kwd>
<kwd lng="es"><![CDATA[BIOMARCADORES]]></kwd>
<kwd lng="en"><![CDATA[VIH]]></kwd>
<kwd lng="en"><![CDATA[CRYPTOCOCCOSIS]]></kwd>
<kwd lng="en"><![CDATA[CEREBROSPINAL FLUID]]></kwd>
<kwd lng="en"><![CDATA[OPPORTUNISTIC INFECTIONS]]></kwd>
<kwd lng="en"><![CDATA[BIOMARKERS]]></kwd>
</kwd-group>
</article-meta>
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