<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1561-3194</journal-id>
<journal-title><![CDATA[Revista de Ciencias Médicas de Pinar del Río]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ciencias Médicas]]></abbrev-journal-title>
<issn>1561-3194</issn>
<publisher>
<publisher-name><![CDATA[Editorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1561-31942023000400021</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Contaminación ambiental por productos farmacéuticos y su impacto en la salud humana]]></article-title>
<article-title xml:lang="en"><![CDATA[Environmental contamination by pharmaceuticals and its impact on human health]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Moreno-Barragán]]></surname>
<given-names><![CDATA[Andrés Sebastián]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Benalcázar-Pozo]]></surname>
<given-names><![CDATA[Carlos Andrés]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bermúdez-del Sol]]></surname>
<given-names><![CDATA[Abdel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Regional Autónoma de Los Andes  ]]></institution>
<addr-line><![CDATA[Ambato ]]></addr-line>
<country>Ecuador</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>27</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1561-31942023000400021&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1561-31942023000400021&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1561-31942023000400021&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: los contaminantes farmacológicos se describen como compuestos ampliamente utilizados no regulados por la legislación ambiental.  Objetivo: caracterizar la contaminación ambiental por medicamentos y su impacto negativo en la salud humana.  Métodos: se realizó una revisión narrativa de la bibliografía disponible utilizando los métodos analíticos sintético e histórico lógico mediante los artículos recuperados desde las bases de datos como PubMed, Scopus, Cinhal, SciELO. Se encontraron 600 artículos, de los cuales se incluyeron 26.  Resultados: en la actualidad, se han identificado diversas problemáticas sobre el impacto ambiental que ha provocado la contaminación por desechos desmedidos de productos farmacológicos al medio ambiente, tales como afecciones tóxicas en animales que ha causado un daño estructural, morfológico y reproductivo de mucho de ellos, así como también el impacto directo o indirecto que pueden recibir los seres humanos.  Conclusiones: la contaminación ambiental por fármacos afecta tanto de forma directa indirecta al ser humano; esto depende de complejas interacciones entre fármacos, compuestos presentes en las aguas residuales y la dinámica del ecosistema. La contaminación ambiental por fármacos afecta el comportamiento de los animales, lo cual influye en la disminución de las poblaciones de peces y el envenenamiento de otros con uso en la ganadería. Este fenómeno afecta los sectores agrícola y ganadero, que repercute de manera indirecta en alimentación y la salud humana.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT Introduction: pharmacological contaminants are described as widely used compounds not regulated by environmental legislation. Objective: to characterize environmental contamination by drugs and their negative impact on human health. Methods: a narrative review of the available literature was carried out using synthetic and historical-logical analytical methods by means of articles retrieved from databases such as PubMed, Scopus, Cinhal, SciELO. A total of 600 articles were found, of which 26 were included. Results: at present, several problems have been identified regarding the environmental impact caused by contamination by excessive waste of pharmacological products in the environment, such as toxic affections in animals that have caused structural, morphological and reproductive damage in many of them, as well as the direct or indirect impact that human beings may receive. Conclusions: Environmental contamination by drugs affects both directly and indirectly human beings; this depends on complex interactions between drugs, compounds present in wastewater and ecosystem dynamics. Environmental contamination by drugs affects the behavior of animals, which influences the decrease in fish populations and the poisoning of others used in livestock farming. This phenomenon affects the agricultural and livestock sectors, which has an indirect impact on food and human health.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[PREPARACIONES FARMACÉUTICAS]]></kwd>
<kwd lng="es"><![CDATA[CONTAMINACIÓN AMBIENTAL]]></kwd>
<kwd lng="es"><![CDATA[RESIDUOS]]></kwd>
<kwd lng="es"><![CDATA[ECOSISTEMA]]></kwd>
<kwd lng="es"><![CDATA[LEGISLACIÓN AMBIENTAL]]></kwd>
<kwd lng="en"><![CDATA[PHARMACEUTICAL PREPARATIONS]]></kwd>
<kwd lng="en"><![CDATA[ENVIRONMENTAL CONTAMINATION]]></kwd>
<kwd lng="en"><![CDATA[WASTE]]></kwd>
<kwd lng="en"><![CDATA[ECOSYSTEM]]></kwd>
<kwd lng="en"><![CDATA[ENVIRONMENTAL LEGISLATION.]]></kwd>
</kwd-group>
</article-meta>
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