<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1561-3194</journal-id>
<journal-title><![CDATA[Revista de Ciencias Médicas de Pinar del Río]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Ciencias Médicas]]></abbrev-journal-title>
<issn>1561-3194</issn>
<publisher>
<publisher-name><![CDATA[Editorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1561-31942023000400025</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Infección por el virus del papiloma humano y carcinoma oral de células escamosas: una revisión sistemática]]></article-title>
<article-title xml:lang="en"><![CDATA[Human papillomavirus infection and oral squamous cell carcinoma: a systematic review]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Monserrath Freire-Neto]]></surname>
<given-names><![CDATA[Gabriela]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Miranda Coello]]></surname>
<given-names><![CDATA[Katherine Cristina]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Patiño Sánchez]]></surname>
<given-names><![CDATA[Kevin Josué]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rodríguez Cuellar]]></surname>
<given-names><![CDATA[Yaima]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Regional Autónoma de los Andes (UNIANDES)  ]]></institution>
<addr-line><![CDATA[ ]]></addr-line>
<country>Ecuador</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2023</year>
</pub-date>
<volume>27</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1561-31942023000400025&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1561-31942023000400025&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1561-31942023000400025&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción:  el carcinoma de células escamosas (CCE) es el cáncer más habitual en la cavidad oral, figura el 5 % de todas las neoplasias y ocupa el número 12 de todas las neoplasias malignas existe una relación entre cuello uterino, la cavidad oral y la orofaringe.  Objetivo:  argumentar la relación entre la infección por el virus del papiloma humano (VPH) y los carcinomas orales de células escamosas.  Métodos:  se realizó una revisión bibliográfica sistemática, fueron revisados 60 artículos indexados en (Pubmed, Scopus, Cochrane Library, Google Scholar y SciELO). Se incluyeron solo revisiones bibliográficas y sistemáticas con menos de 10 años de publicación, basadas en estudios con seres humanos, publicadas en inglés o español y con el texto disponible. Todos aquellos estudios que no cumplían estos parámetros fueron excluidos, quedando un total de 16 resultados.  Desarrollo:  el carcinoma de células escamosas representa el 90 % de las neoplasias malignas de la cavidad oral y la orofaringe. Existen varios tipos de VPH entre ellos 201 tipos que se diferencian debido a variaciones en la secuencia de ADN de L1. La literatura deduce que el 17,8 % de todos los cánceres son estimulados por agentes de tipo contagioso y el 12,1 % pertenece a virus, esto obliga a inquirir más al respecto al VPH como agente carcinógeno y su contribución en el carcinoma de células escamosas (CCE) en cavidad oral y orofaringe.  Conclusiones:  los mecanismos carcinogénicos que utiliza el VPH para la transformación celular son mediante las proteínas E6 y E7 como responsables del proceso de malignización.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction: squamous cell carcinoma (SCC) is the most common cancer in the oral cavity, it represents 5 % of all neoplasms and occupies number 12 of all malignant neoplasms, there is a relationship between the cervix, oral cavity and oropharynx.  Objective: to argue the relationship between human papillomavirus (HPV) infection and oral squamous cell carcinomas.  Methods: a systematic literature review was performed, 60 articles indexed in (Pubmed, Scopus, Cochrane Library, Google Scholar and SciELO) were reviewed. Only bibliographic and systematic reviews with less than 10 years of publication, based on human studies, published in English or Spanish and with the text available were included. All those studies that did not meet these parameters were excluded, leaving a total of 16 results.  Development: squamous cell carcinoma represents 90 % of malignant neoplasms of the oral cavity and oropharynx. There are several HPV types among them 201 types that differ due to variations in the L1 DNA sequence. The literature deduces that 17,8 % of all cancers are stimulated by contagious type agents and 12,1 % belong to viruses, this forces to inquire more about HPV as a carcinogenic agent and its contribution in squamous cell carcinoma (SCC) in oral cavity and oropharynx.  Conclusions: the carcinogenic mechanisms used by HPV for cell transformation are through E6 and E7 proteins as responsible for the malignization process.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[VIRUS DEL PAPILOMA HUMANO]]></kwd>
<kwd lng="es"><![CDATA[CÁNCER ORAL]]></kwd>
<kwd lng="es"><![CDATA[CÁNCER OROFARÍNGEO]]></kwd>
<kwd lng="es"><![CDATA[CARCINOMA DE CÉLULAS ESCAMOSAS]]></kwd>
<kwd lng="en"><![CDATA[HUMAN PAPILLOMAVIRUS VIRUSES]]></kwd>
<kwd lng="en"><![CDATA[MOUTH NEOPLASMS]]></kwd>
<kwd lng="en"><![CDATA[OROPHARYNGEAL NEOPLASMS]]></kwd>
<kwd lng="en"><![CDATA[CARCINOMA, SQUAMOUS CELL]]></kwd>
</kwd-group>
</article-meta>
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