<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1608-8921</journal-id>
<journal-title><![CDATA[Gaceta Médica Espirituana]]></journal-title>
<abbrev-journal-title><![CDATA[Gac Méd Espirit]]></abbrev-journal-title>
<issn>1608-8921</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de Sancti Spíritus]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1608-89212019000200087</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Carcinoma basocelular del rostro tratado con HeberFERON]]></article-title>
<article-title xml:lang="en"><![CDATA[Basal cell carcinoma of the face treated with HeberFERON]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez Linares]]></surname>
<given-names><![CDATA[Vladimir]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Cifuentes Suarez]]></surname>
<given-names><![CDATA[Juan Pablo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Martínez Cuervo]]></surname>
<given-names><![CDATA[John Jairo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Román Simón]]></surname>
<given-names><![CDATA[Maylin]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Pérez García]]></surname>
<given-names><![CDATA[Claritza]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Bello Rivero]]></surname>
<given-names><![CDATA[Iraldo]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Policlínico Centro  ]]></institution>
<addr-line><![CDATA[Sancti Spíritus ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Centro de Ingeniería Genética y Biotecnología  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>08</month>
<year>2019</year>
</pub-date>
<volume>21</volume>
<numero>2</numero>
<fpage>87</fpage>
<lpage>97</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1608-89212019000200087&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1608-89212019000200087&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1608-89212019000200087&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Fundamento:  El carcinoma basocelular es el cáncer de piel no melanoma más frecuente, es un tumor de invasión local y crecimiento lento; su origen son las células epidérmicas de los folículos pilosos o las células basales de la epidermis; en ocasiones puede sufrir un crecimiento incontrolado, no responder a los tratamientos y ser causa de deformidad; las radiaciones ultravioletas son el principal factor en la génesis de esta enfermedad.  Objetivo:  Describir los resultados de la aplicación de HeberFERON en una serie de casos con carcinoma basocelular del rostro.  Metodología:  Se realizó un estudio observacional, descriptivo longitudinal en una serie de 32 casos clínicos de carcinoma basocelular del rostro que acudieron a la consulta de dermatología del Policlínico Centro. Se incluyeron aquellos con diagnóstico clínico, dermatoscópico e histopatológico. Se realizó una evaluación inicial, durante el tratamiento y 16 semanas después del mismo, se le administró 10.5 UI de HeberFERON 3 veces por semana hasta completar 9 dosis. Las variables fueron la respuesta al tratamiento y presencia o no de eventos adversos.  Resultados:  Predominó el sexo masculino, la piel blanca y la localización de la neoplasia en la nariz, se logró respuesta completa en la mayoría de los pacientes. Como eventos adversos se presentaron dolor en el sitio de inyección, fiebre y malestar general.  Conclusiones:  La respuesta objetiva al tratamiento fue favorable en la mayoría de los pacientes tratados con HeberFERON.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Background:  Basal cell carcinoma is the most frequent non-melanoma skin cancer, it is a tumor of local invasion and slow growth; it has its origin from the epidermal cells of the hair follicles or the basal cells of the epidermis; sometimes it can suffer uncontrolled growth, not respond to treatments and cause deformity; ultraviolet radiation is the main factor in the genesis of this disease.  Objective:  To describe the results of the application of HeberFERON in a series of cases with basal cell carcinoma of the face.  Methodology:  An observational, longitudinal descriptive study was carried out in a series of 32 clinical cases of basal cell carcinoma of the face that attended the dermatology office of the Polyclinic Center. Those with clinical, dermatoscopic and histopathological diagnosis were included. An initial evaluation was carried out, during the treatment and 16 weeks after it, 10.5 IU of HeberFERON was administered 3 times per week until 9 doses were completed. The variables were the response to treatment and the presence or absence of adverse events.  Results:  Male sex, white skin and the location of the neoplasm in the nose predominated; a complete response was achieved in most patients. Adverse events presented pain at the injection site, fever and malaise.  Conclusions:  The objective response to treatment was favorable in the majority of patients treated with HeberFERON.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Carcinoma basocelular]]></kwd>
<kwd lng="es"><![CDATA[cáncer de piel no melanoma]]></kwd>
<kwd lng="es"><![CDATA[NEOPLASIAS CUTÁNEAS]]></kwd>
<kwd lng="es"><![CDATA[tratamiento farmacológico]]></kwd>
<kwd lng="es"><![CDATA[HeberFERON]]></kwd>
<kwd lng="es"><![CDATA[rostro]]></kwd>
<kwd lng="en"><![CDATA[Basal cell carcinoma]]></kwd>
<kwd lng="en"><![CDATA[non-melanoma skin cancer]]></kwd>
<kwd lng="en"><![CDATA[skin neoplasms]]></kwd>
<kwd lng="en"><![CDATA[drug therapy]]></kwd>
<kwd lng="en"><![CDATA[HeberFERON]]></kwd>
<kwd lng="en"><![CDATA[face]]></kwd>
</kwd-group>
</article-meta>
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