<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1682-0037</journal-id>
<journal-title><![CDATA[Revista Cubana de Angiología y Cirugía Vascular]]></journal-title>
<abbrev-journal-title><![CDATA[Rev Cubana Angiol Cir Vasc]]></abbrev-journal-title>
<issn>1682-0037</issn>
<publisher>
<publisher-name><![CDATA[Centro Nacional de Información de Ciencias MédicasEditorial Ciencias Médicas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1682-00372021000100012</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Stimul W® y Heberprot-P® unidos en el tratamiento de la úlcera del pie diabético]]></article-title>
<article-title xml:lang="en"><![CDATA[Stimul W® and Heberprot-P® combined for treating diabetic foot ulcer]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Fernández Montequín]]></surname>
<given-names><![CDATA[José I.]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[La O Hernández]]></surname>
<given-names><![CDATA[Elsa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Suen Díaz]]></surname>
<given-names><![CDATA[Juan Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Instituto Nacional de Angiología y Cirugía Vascular  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Combiomed Tecnología Médica Digital  ]]></institution>
<addr-line><![CDATA[La Habana ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2021</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2021</year>
</pub-date>
<volume>22</volume>
<numero>1</numero>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1682-00372021000100012&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1682-00372021000100012&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1682-00372021000100012&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Introducción: Las úlceras del pie diabético resultan las complicaciones más frecuentes en las personas con diabetes. Se conocen diferentes formas de tratamiento para esta enfermedad, con más o menos efectividad, pero no resuelven el problema en la totalidad de los casos. El estimulador eléctrico Stimul W® y el medicamento Heberprot-P® se han empleado, de manera independiente y con resultados satisfactorios, como alternativas para el tratamiento de estas lesiones. Comprobar si la acción combinada de ambos procedimientos permite alcanzar mejores resultados, permitiría contribuir a resolver un problema de alta prevalencia mundial.  Objetivo: Exponer el resultado de la aplicación de la combinación del estimulador Stimul W® y el medicamento Heberprot-P® en el tratamiento de un paciente con úlcera del pie diabético.  Presentación del caso: Paciente masculino de 69 años de edad, con diabetes mellitus de tipo 2, que presentaba una úlcera del pie diabético en la parte externa del pie derecho, con abundante tejido necrótico en forma de fístula en la base de los dos dedos restantes y falta de granulación. Los tratamientos anteriores no dieron el resultado esperado. Se decidió, como terapia de curación, aplicar durante 12 sesiones la combinación del estimulador Stimul W® y el medicamento Heberprot-P®.  Conclusiones: Se logró la cicatrización de la lesión, al obtener un 100 % de tejido de granulación y la disminución significativa de sus dimensiones, lo que mostró que la terapia aplicada constituye una alternativa para el tratamiento de este tipo de úlcera.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Introduction:  Diabetic foot ulcers are the most frequent complications in people with diabetes. Different forms of treatment for this disease are known, with more or less effectiveness; but they do not solve the problem in all cases. The electrical stimulator Stimul W® and the drug Heberprot-P® have been used independently, and with satisfactory outcomes, as alternatives for the treatment of these lesions. Checking whether the combined action of both procedures allows to achieve better outcomes would contribute to solve a problem of high worldwide prevalence.  Objective:  To present the outcomes of applying the combination of the stimulator Stimul W® and the drug Heberprot-P® for treating a patient with diabetic foot ulcer.  Case presentation:  A 69-year-old male patient, with type 2 diabetes mellitus, who presented with a diabetic foot ulcer on the outside of the right foot, with abundant necrotic tissue in the form of a fistula at the base of the two remaining toes and lack of granulation. The previous treatments did not permit the expected outcomes. It was decided, as a healing therapy, to apply the combination of the stimulator Stimul W® and the drug Heberprot-P® for twelve sessions.  Conclusions:  Healing of the lesion was achieved by obtaining 100% granulation tissue and a significant reduction in its dimensions, which showed that the applied therapy constitutes an alternative for the treatment of this type of ulcer.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[úlcera del pie diabético]]></kwd>
<kwd lng="es"><![CDATA[estimulación eléctrica]]></kwd>
<kwd lng="es"><![CDATA[diabetes mellitus]]></kwd>
<kwd lng="es"><![CDATA[factor de crecimiento epidérmico]]></kwd>
<kwd lng="es"><![CDATA[Heberprot-P®]]></kwd>
<kwd lng="es"><![CDATA[Stimul W®]]></kwd>
<kwd lng="en"><![CDATA[diabetic foot ulcer]]></kwd>
<kwd lng="en"><![CDATA[electric stimulation]]></kwd>
<kwd lng="en"><![CDATA[diabetes mellitus]]></kwd>
<kwd lng="en"><![CDATA[epidermal growth factor]]></kwd>
<kwd lng="en"><![CDATA[Heberprot-P®]]></kwd>
<kwd lng="en"><![CDATA[Stimul W®]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vanderwee]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Clark]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Dealey]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Gunningberg]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Defloor]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pressure ulcer prevalence in Europe: a pilot study]]></article-title>
<source><![CDATA[J Eval Clin Pract]]></source>
<year>2007</year>
<volume>13</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>227-35</page-range></nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Leyva-Moral]]></surname>
<given-names><![CDATA[JM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Úlceras por presión y la ética del cuidado a propósito de un caso]]></article-title>
<source><![CDATA[Rev Soc Med Quir. Hospital Emergencia Pérez de León]]></source>
<year>2007</year>
<volume>38</volume>
<numero>^s1</numero>
<issue>^s1</issue>
<supplement>1</supplement>
<page-range>8-11</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Dougherty]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
</person-group>
<source><![CDATA[Digital Image Processing for Medical Applications]]></source>
<year>2009</year>
<publisher-name><![CDATA[Cambridge University Press]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Suen]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
<name>
<surname><![CDATA[Folgueras]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Fornells]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Díaz]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Zamarreño]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Estimulador eléctrico para tratamiento de las úlceras por presión]]></article-title>
<source><![CDATA[Rev Universidad, Ciencia y Tecnología]]></source>
<year>1999</year>
<volume>3</volume>
<numero>9</numero>
<issue>9</issue>
<page-range>9-12</page-range></nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Junco]]></surname>
<given-names><![CDATA[DA]]></given-names>
</name>
<name>
<surname><![CDATA[Moncada]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Montoya]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Eficacia del Heberprot-P en el tratamiento de las úlceras del pie diabético]]></article-title>
<source><![CDATA[Medisan]]></source>
<year>2012</year>
<volume>16</volume>
<numero>11</numero>
<issue>11</issue>
<page-range>1707</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ruiz]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[El Heberprot-P]]></article-title>
<source><![CDATA[Rev. Esp. de Pod]]></source>
<year>2015</year>
<volume>26</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>12-4</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Berlanga]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Heberprot-P: antecedentes experimentales y bases farmacológicas]]></article-title>
<source><![CDATA[Biotecnología Aplicada]]></source>
<year>2010</year>
<volume>27</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>88-94</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Suen]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
<name>
<surname><![CDATA[Marrero]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Baly]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Curación de úlceras empleando estimulación eléctrica en instituciones primarias de salud]]></article-title>
<source><![CDATA[Rev. Universidad, Ciencia y Tecnología]]></source>
<year>2008</year>
<volume>12</volume>
<numero>48</numero>
<issue>48</issue>
<page-range>143-6</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Suen]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
<name>
<surname><![CDATA[Folgueras]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Carrasco]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Gómez]]></surname>
<given-names><![CDATA[MA]]></given-names>
</name>
<name>
<surname><![CDATA[Febles]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Zamarreño]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Curación de úlceras por presión y úlceras varicosas con el empleo de pulsos bifásicos de estimulación eléctrica]]></article-title>
<source><![CDATA[Revista del Hospital Nacional "Baldomero Sommer". República de la Argentina]]></source>
<year>2000</year>
<volume>3</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>19-25</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Simón]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Carrasco]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Rosell]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
<name>
<surname><![CDATA[Suárez]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
<name>
<surname><![CDATA[Suen]]></surname>
<given-names><![CDATA[JE]]></given-names>
</name>
<name>
<surname><![CDATA[Folgueras]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Application of electrical stimulation to the healing of different types of ulcers Engineering in Medicine and Biology Society, 2003]]></article-title>
<source><![CDATA[Proceedings of the 25th Annual International Conference of the IEEE]]></source>
<year>2005</year>
<volume>2</volume>
<page-range>1720-3</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Feedar]]></surname>
<given-names><![CDATA[JA]]></given-names>
</name>
<name>
<surname><![CDATA[Kloth]]></surname>
<given-names><![CDATA[LC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Acceleration of wound healing with high voltage pulsating direct current]]></article-title>
<source><![CDATA[Physical Therapy]]></source>
<year>1988</year>
<volume>68</volume>
<numero>4</numero>
<issue>4</issue>
<page-range>503-8</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Biedebach]]></surname>
<given-names><![CDATA[MC]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Accelerated healing of skin ulcers by electrical stimulation and the intracellular physiological mechanisms involved]]></article-title>
<source><![CDATA[Acup &amp; Electro-Ter. Res J]]></source>
<year>1989</year>
<volume>14</volume>
<page-range>43-60</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Poletto]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Van Doren]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[A high voltage, constant current stimulator for electrocutaneous stimulation through small electrodes]]></article-title>
<source><![CDATA[IEEE Trans Biomed Eng]]></source>
<year>1999</year>
<volume>46</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>929-36</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
