<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1684-1824</journal-id>
<journal-title><![CDATA[Revista Médica Electrónica]]></journal-title>
<abbrev-journal-title><![CDATA[Rev.Med.Electrón.]]></abbrev-journal-title>
<issn>1684-1824</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de Matanzas]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1684-18242024000100071</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Factores de riesgo que contribuyen a la neuroinflamación crónica y disfunción cerebral]]></article-title>
<article-title xml:lang="en"><![CDATA[Risk factors that contribute to chronic neuro-inflammation and brain dysfunction]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Rufín-Gómez]]></surname>
<given-names><![CDATA[Lorenzo Ángel]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Vega-Socorro]]></surname>
<given-names><![CDATA[Martha Noraida]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García-García]]></surname>
<given-names><![CDATA[Diana Rosa]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad de Ciencias Médicas de Matanzas  ]]></institution>
<addr-line><![CDATA[ Matanzas]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>00</month>
<year>2024</year>
</pub-date>
<volume>46</volume>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1684-18242024000100071&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1684-18242024000100071&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1684-18242024000100071&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN El estilo de vida saludable conlleva un comportamiento adaptable, que es fundamental para la salud mental del hombre e incluye aspectos relacionados con los factores ambientales. La revisión tuvo como objetivo mostrar los avances en las investigaciones sobre los factores de riesgo que contribuyen a la neuroinflamación crónica, sus efectos a nivel cerebral, así como el papel de un estilo de vida saludable en promover la neuroplasticidad. Para ello se realizaron búsquedas principalmente en la base de datos PubMed, y como resultado, se confirmó una asociación positiva entre los estados inflamatorios subclínicos surgidos de estilos de vida poco saludables, y la neuroinflamación crónica con la consecuente neurodegeneración. Lo anterior derivó como conclusión que algunos factores de riesgo como la dieta poco saludable, la obesidad, el estrés, la depresión, la falta de ejercicio físico y los desórdenes del ciclo circadiano son factores conductuales modificables, que deben ser objeto de atención y solución, tanto en lo individual como en lo social. Todo ello resulta un aspecto preocupante en el tema de las enfermedades neurodegenerativas y su enorme costo para la sociedad futura.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT A healthy lifestyle involves adaptive behavior, which is fundamental for men's mental health, and includes aspects related to the environmental factors. The review aimed to show advances in research on the risk factors that contribute to chronic neuro-inflammation, its effects at the brain level, as well as the role of a healthy lifestyle in promoting neuroplasticity. For this purpose, searches were carried out mainly in the PubMed database, and as a result, a positive association was confirmed between subclinical inflammatory states arising from unhealthy lifestyles, and chronic neuro-inflammation with consequent neuro-degeneration. The above led to the conclusion that some risk factors such as unhealthy diet, obesity, stress, depression, lack of physical exercise, and circadian cycle disorders are modifiable behavioral factors, which should be the object of attention and solution, both individually and socially. All of this is a worrying aspect of the issue of neurodegenerative diseases and their enormous cost for future society.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[neuroinflamación]]></kwd>
<kwd lng="es"><![CDATA[microglía]]></kwd>
<kwd lng="es"><![CDATA[estrés]]></kwd>
<kwd lng="es"><![CDATA[obesidad]]></kwd>
<kwd lng="es"><![CDATA[enfermedades neurodegenerativas]]></kwd>
<kwd lng="en"><![CDATA[neuro-inflammation]]></kwd>
<kwd lng="en"><![CDATA[microglia]]></kwd>
<kwd lng="en"><![CDATA[stress]]></kwd>
<kwd lng="en"><![CDATA[obesity]]></kwd>
<kwd lng="en"><![CDATA[neurodegenerative diseases]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Augusto-Oliveira]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Verkhratsky]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Lifestyle-dependent microglial plasticity: training the brain guardians]]></article-title>
<source><![CDATA[Biol Direct]]></source>
<year>2021</year>
<volume>16</volume>
<numero>1</numero>
<issue>1</issue>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Verkhratsky]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Augusto-Oliveira]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Pivoriunas]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Astroglial asthenia and loss of function, rather than reactivity, contribute to the ageing of the brain]]></article-title>
<source><![CDATA[Pflugers Arch]]></source>
<year>2021</year>
<volume>473</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>753-74</page-range></nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mendes]]></surname>
<given-names><![CDATA[NF]]></given-names>
</name>
<name>
<surname><![CDATA[Jara]]></surname>
<given-names><![CDATA[CP]]></given-names>
</name>
<name>
<surname><![CDATA[Zanesco]]></surname>
<given-names><![CDATA[AM]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Hypothalamic Microglial Heterogeneity and Signature under High Fat Diet-Induced Inflammation]]></article-title>
<source><![CDATA[Int J Mol Sci]]></source>
<year>2021</year>
<volume>22</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>2256</page-range></nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ferro]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Auguste]]></surname>
<given-names><![CDATA[YSS]]></given-names>
</name>
<name>
<surname><![CDATA[Cheadle]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Microglia, Cytokines, and Neural Activity: Unexpected Interactions in Brain Development and Function]]></article-title>
<source><![CDATA[Front Immunol]]></source>
<year>2021</year>
<volume>12</volume>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Romero-Molina]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Navarro]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Jimenez]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Should We Open Fire on Microglia? Depletion Models as Tools to Elucidate Microglial Role in Health and Alzheimer's Disease]]></article-title>
<source><![CDATA[Int J Mol Sci]]></source>
<year>2021</year>
<volume>22</volume>
<numero>18</numero>
<issue>18</issue>
<page-range>9734</page-range></nlm-citation>
</ref>
<ref id="B6">
<label>6</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Augusto-Oliveira]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Verkhratsky]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Mens sana in corpore sano: lifestyle changes modify astrocytes to contain Alzheimer's disease]]></article-title>
<source><![CDATA[Neural Regen Res]]></source>
<year>2021</year>
<volume>16</volume>
<numero>8</numero>
<issue>8</issue>
<page-range>1548-9</page-range></nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhuang]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Yao]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Long-term high-fat diet consumption by mice throughout adulthood induces neurobehavioral alterations and hippocampal neuronal remodeling accompanied by augmented microglia lipid accumulation]]></article-title>
<source><![CDATA[Brain Behav Immun]]></source>
<year>2022</year>
<volume>100</volume>
<page-range>155-71</page-range></nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cope]]></surname>
<given-names><![CDATA[EC]]></given-names>
</name>
<name>
<surname><![CDATA[LaMarca]]></surname>
<given-names><![CDATA[EA]]></given-names>
</name>
<name>
<surname><![CDATA[Monari]]></surname>
<given-names><![CDATA[PK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Microglia Play an Active Role in Obesity-Associated Cognitive Decline]]></article-title>
<source><![CDATA[J Neurosci]]></source>
<year>2018</year>
<volume>38</volume>
<numero>41</numero>
<issue>41</issue>
<page-range>8889-904</page-range></nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Nyamugenda]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Trentzsch]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Russell]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Injury to Hypothalamic Sim1 Neurons Is a Common Feature of Obesity by Exposure to High-Fat Diet in Male and Female Mice]]></article-title>
<source><![CDATA[J Neurochem]]></source>
<year>2019</year>
<volume>149</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>73-97</page-range></nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Hao]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Dey]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Yu]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dietary Obesity Reversibly Induces Synaptic Stripping by Microglia and Impairs Hippocampal Plasticity]]></article-title>
<source><![CDATA[Brain Behav Immun]]></source>
<year>2016</year>
<volume>51</volume>
<page-range>230-9</page-range></nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kim]]></surname>
<given-names><![CDATA[JD]]></given-names>
</name>
<name>
<surname><![CDATA[Yoon]]></surname>
<given-names><![CDATA[NA]]></given-names>
</name>
<name>
<surname><![CDATA[Jin]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Microglial UCP2 Mediates Inflammation and Obesity Induced by High-Fat Feeding]]></article-title>
<source><![CDATA[Cell Metab]]></source>
<year>2019</year>
<volume>30</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>P952-62</page-range></nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Urso]]></surname>
<given-names><![CDATA[CJ]]></given-names>
</name>
<name>
<surname><![CDATA[Zhou]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Palmitic Acid Lipotoxicity in Microglia Cells Is Ameliorated by Unsaturated Fatty Acids]]></article-title>
<source><![CDATA[Int J Mol Sci]]></source>
<year>2021</year>
<volume>22</volume>
<numero>16</numero>
<issue>16</issue>
<page-range>9093</page-range></nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Cansell]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Stobbe]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Sanchez]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Dietary Fat Exacerbates Postprandial Hypothalamic Inflammation Involving Glial Fibrillary Acidic Protein-Positive Cells and Microglia in Male Mice]]></article-title>
<source><![CDATA[Glia]]></source>
<year>2021</year>
<volume>69</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>42-60</page-range></nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Baranowski]]></surname>
<given-names><![CDATA[BJ]]></given-names>
</name>
<name>
<surname><![CDATA[Marko]]></surname>
<given-names><![CDATA[DM]]></given-names>
</name>
<name>
<surname><![CDATA[Fenech]]></surname>
<given-names><![CDATA[RK]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Healthy brain, healthy life: a review of diet and exercise interventions to promote brain health and reduce Alzheimer's disease risk]]></article-title>
<source><![CDATA[Appl Physiol Nutr Metab]]></source>
<year>2020</year>
<volume>45</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>1055-65</page-range></nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Madore]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Yin]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
<name>
<surname><![CDATA[Leibowitz]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Microglia, Lifestyle Stress, and Neurodegeneration]]></article-title>
<source><![CDATA[Immunity]]></source>
<year>2020</year>
<volume>52</volume>
<numero>2</numero>
<issue>2</issue>
<page-range>222-40</page-range></nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Richter-Levin]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Xu]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[How could stress lead to major depressive disorder?]]></article-title>
<source><![CDATA[IBRO Rep]]></source>
<year>2018</year>
<volume>4</volume>
<page-range>38-43</page-range></nlm-citation>
</ref>
<ref id="B17">
<label>17</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Carloni]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Ramos]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Hayes]]></surname>
<given-names><![CDATA[LN]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Developmental Stressors Induce Innate Immune Memory in Microglia and Contribute to Disease Risk]]></article-title>
<source><![CDATA[Int J Mol Sci]]></source>
<year>2021</year>
<volume>22</volume>
<numero>23</numero>
<issue>23</issue>
<page-range>13035</page-range></nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Scuderi]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Verkhratsky]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Parpura]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neuroglia in Psychiatric Disorders]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Li]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
<name>
<surname><![CDATA[Parpura]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
<name>
<surname><![CDATA[Verkhratsky]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
</person-group>
<source><![CDATA[Astrocytes in Psychiatric Disorders. Advances in Neurobiology]]></source>
<year>2021</year>
<publisher-name><![CDATA[Cham: Springer International Publishing]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Antoniou]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Lambourg]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Steele]]></surname>
<given-names><![CDATA[JD]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis]]></article-title>
<source><![CDATA[Br J Anaesth]]></source>
<year>2023</year>
<volume>130</volume>
<numero>6</numero>
<issue>6</issue>
<page-range>729-46</page-range></nlm-citation>
</ref>
<ref id="B20">
<label>20</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Bueno-Notivol]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Gracia-García]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Olaya]]></surname>
<given-names><![CDATA[B]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Prevalence of depression during the COVID-19 outbreak: A meta-analysis of community-based studies]]></article-title>
<source><![CDATA[Int J Clin Health Psychol]]></source>
<year>2021</year>
<volume>21</volume>
<numero>1</numero>
<issue>1</issue>
<page-range>100196</page-range></nlm-citation>
</ref>
<ref id="B21">
<label>21</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kwon]]></surname>
<given-names><![CDATA[HS]]></given-names>
</name>
<name>
<surname><![CDATA[Koh]]></surname>
<given-names><![CDATA[SH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes]]></article-title>
<source><![CDATA[Transl Neurodegener]]></source>
<year>2020</year>
<volume>9</volume>
<numero>42</numero>
<issue>42</issue>
</nlm-citation>
</ref>
<ref id="B22">
<label>22</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Malpetti]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Kievit]]></surname>
<given-names><![CDATA[RA]]></given-names>
</name>
<name>
<surname><![CDATA[Passamonti]]></surname>
<given-names><![CDATA[L]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Microglial activation and tau burden predict cognitive decline in Alzheimer's disease]]></article-title>
<source><![CDATA[Brain]]></source>
<year>2020</year>
<volume>143</volume>
<numero>5</numero>
<issue>5</issue>
<page-range>1588-602</page-range></nlm-citation>
</ref>
<ref id="B23">
<label>23</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yang]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Magnutzki]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Alami]]></surname>
<given-names><![CDATA[NO]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[IKK2/NF-&#954;B Activation in Astrocytes Reduces amyloid &#946; Deposition: A Process Associated with Specific Microglia Polarization]]></article-title>
<source><![CDATA[Cells]]></source>
<year>2021</year>
<volume>10</volume>
<numero>10</numero>
<issue>10</issue>
<page-range>2669</page-range></nlm-citation>
</ref>
<ref id="B24">
<label>24</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Angelopoulou]]></surname>
<given-names><![CDATA[E]]></given-names>
</name>
<name>
<surname><![CDATA[Paudel]]></surname>
<given-names><![CDATA[YN]]></given-names>
</name>
<name>
<surname><![CDATA[Shaikh]]></surname>
<given-names><![CDATA[MF]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fractalkine (CX3CL1) Signaling and Neuroinflammation in Parkinson&#8217;s Disease: Potential Clinical and Therapeutic Implications]]></article-title>
<source><![CDATA[Pharmacol Res]]></source>
<year>2020</year>
<volume>158</volume>
<page-range>104930</page-range></nlm-citation>
</ref>
<ref id="B25">
<label>25</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Singhal]]></surname>
<given-names><![CDATA[G]]></given-names>
</name>
<name>
<surname><![CDATA[Morgan]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Corrigan]]></surname>
<given-names><![CDATA[F]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Short-Term Environmental enrichment is a stronger modulator of brain glial cells and cervical lymph node T cell subtypes than exercise or combined exercise and enrichment]]></article-title>
<source><![CDATA[Cell Mol Neurobiol]]></source>
<year>2021</year>
<volume>41</volume>
<numero>3</numero>
<issue>3</issue>
<page-range>469-86</page-range></nlm-citation>
</ref>
<ref id="B26">
<label>26</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Xiao]]></surname>
<given-names><![CDATA[K]]></given-names>
</name>
<name>
<surname><![CDATA[Luo]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Liang]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Beneficial effects of running exercise on hippocampal microglia and neuroinflammation in chronic unpredictable stress-induced depression model rats]]></article-title>
<source><![CDATA[Transl Psychiatry]]></source>
<year>2021</year>
<volume>11</volume>
<numero>461</numero>
<issue>461</issue>
</nlm-citation>
</ref>
<ref id="B27">
<label>27</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Meng]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
<name>
<surname><![CDATA[Lin]]></surname>
<given-names><![CDATA[MS]]></given-names>
</name>
<name>
<surname><![CDATA[Tzeng]]></surname>
<given-names><![CDATA[IS]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Relationship between exercise and Alzheimer's disease: a narrative literature review]]></article-title>
<source><![CDATA[Front Neurosci]]></source>
<year>2020</year>
<volume>14</volume>
<page-range>131</page-range></nlm-citation>
</ref>
<ref id="B28">
<label>28</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Koronowski]]></surname>
<given-names><![CDATA[KB]]></given-names>
</name>
<name>
<surname><![CDATA[Sassone-Corsi]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Communicating Clocks Shape Circadian Homeostasis]]></article-title>
<source><![CDATA[Science]]></source>
<year>2021</year>
<volume>371</volume>
<numero>6530</numero>
<issue>6530</issue>
</nlm-citation>
</ref>
<ref id="B29">
<label>29</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Panagiotou]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Michel]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Meijer]]></surname>
<given-names><![CDATA[JH]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[The aging brain: sleep, the circadian clock and exercise]]></article-title>
<source><![CDATA[Biochem Pharm]]></source>
<year>2021</year>
<volume>191</volume>
<page-range>114563</page-range></nlm-citation>
</ref>
<ref id="B30">
<label>30</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Yoo]]></surname>
<given-names><![CDATA[ID]]></given-names>
</name>
<name>
<surname><![CDATA[Park]]></surname>
<given-names><![CDATA[MW]]></given-names>
</name>
<name>
<surname><![CDATA[Cha]]></surname>
<given-names><![CDATA[HW]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Elevated CLOCK and BMAL1 Contribute to the Impairment of Aerobic Glycolysis From Astrocytes in Alzheimer&#8217;s Disease]]></article-title>
<source><![CDATA[Int J Mol Sci]]></source>
<year>2020</year>
<volume>21</volume>
<numero>21</numero>
<issue>21</issue>
<page-range>7862</page-range></nlm-citation>
</ref>
</ref-list>
</back>
</article>
