<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1727-897X</journal-id>
<journal-title><![CDATA[MediSur]]></journal-title>
<abbrev-journal-title><![CDATA[Medisur]]></abbrev-journal-title>
<issn>1727-897X</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de Cienfuegos, Centro Provincial de Ciencias Médicas, Provincia de Cienfuegos.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1727-897X2022000200374</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Utilidad diagnóstica de pruebas rápidas para detectar anticuerpos IgG/IgM anti COVID-19]]></article-title>
<article-title xml:lang="en"><![CDATA[Diagnostic utility of rapid tests to detect IgG/IgM antibodies against COVID-19]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez Frenes]]></surname>
<given-names><![CDATA[Pedro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[García Torres]]></surname>
<given-names><![CDATA[Dayamí]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Sánchez Bouza]]></surname>
<given-names><![CDATA[María de Jesús]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Mendoza Cartaya]]></surname>
<given-names><![CDATA[Gippsy]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Portela Sánchez]]></surname>
<given-names><![CDATA[Mavis]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Banco Provincial de Sangre  ]]></institution>
<addr-line><![CDATA[Cienfuegos ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Centro Especializado Ambulatorio Héroes de Playa Girón  ]]></institution>
<addr-line><![CDATA[Cienfuegos ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad de Ciencias Médicas de Cienfuegos  ]]></institution>
<addr-line><![CDATA[Cienfuegos ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af4">
<institution><![CDATA[,Centro Provincial de Higiene, Epidemiología y Microbiología de Cienfuegos  ]]></institution>
<addr-line><![CDATA[Cienfuegos ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>04</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>04</month>
<year>2022</year>
</pub-date>
<volume>20</volume>
<numero>2</numero>
<fpage>374</fpage>
<lpage>381</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1727-897X2022000200374&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1727-897X2022000200374&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1727-897X2022000200374&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Fundamento  Las pruebas rápidas para el diagnóstico del SARS-CoV-2 constituyen opciones atractivas por su simplicidad, rapidez y rentabilidad; pero poseen diferentes grados de sensibilidad y especificad diagnóstica.  Objetivo  evaluar el desempeño analítico de pruebas rápidas para detectar anticuerpos IgG/IgM anti COVID-19.  Métodos  estudio descriptivo, realizado con los pacientes ingresados en el Centro Especializado Ambulatorio Héroes de Playa Girón, de Cienfuegos, con diagnóstico presuntivo, probable o confirmado de COVID-19 durante dos períodos de tiempo. A todos se les realizó la prueba rápida para detectar anticuerpos anti COVID-19, además de un ensayo confirmatorio por biología molecular. Se calcularon la sensibilidad y especificidad diagnósticas, los valores predictivos y la eficiencia de la prueba rápida dentro de un intervalo de confianza del 95 %.  Resultados  se obtuvo una excelente especificidad (98,75 %) y regular sensibilidad (54,54 %), así como buenos valores predictivos y eficiencia diagnóstica global.  Conclusión  Las pruebas rápidas anti COVID-19 evaluadas mostraron un desempeño diagnóstico adecuado. Resultan una alternativa diagnóstica asequible y valiosa para evaluar exposición previa al SARS-CoV-2. Su uso clínico está restringido para ciertas situaciones médicas; sin embargo, constituyen una herramienta epidemiológica útil.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Background  Rapid tests for the diagnosis of SARS-CoV-2 are attractive options due to their simplicity, speed and cost-effectiveness; but they have different degrees of sensitivity and diagnostic specificity.  Objective  to evaluate the analytical performance of rapid tests to detect IgG/IgM antibodies against COVID-19.  Methods  descriptive study, carried out with patients admitted to the Héroes de Playa Girón Specialized Ambulatory Center, in Cienfuegos, with a presumptive, probable or confirmed diagnosis of COVID-19 during two periods of time. All of them underwent a rapid test to detect anti-COVID-19 antibodies, in addition to a confirmatory molecular biology test. Diagnostic sensitivity and specificity, predictive values, and rapid test efficiency were calculated within a 95% confidence interval.  Results  excellent specificity (98.75%) and regular sensitivity (54.54%) were obtained, as well as good predictive values and overall diagnostic efficiency.  Conclusion  The rapid anti-COVID-19 tests evaluated showed adequate diagnostic performance. They constitute an affordable and valuable diagnostic alternative to assess previous exposure to SARS-CoV-2. Its clinical use is restricted to certain medical situations; however, they constitute a useful epidemiological tool.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Anticuerpos]]></kwd>
<kwd lng="es"><![CDATA[infección por coronavirus]]></kwd>
<kwd lng="es"><![CDATA[técnicas de laboratorio clínico]]></kwd>
<kwd lng="es"><![CDATA[pruebas serológicas]]></kwd>
<kwd lng="en"><![CDATA[Antibody]]></kwd>
<kwd lng="en"><![CDATA[coronavirus infection]]></kwd>
<kwd lng="en"><![CDATA[clinical laboratory techniques]]></kwd>
<kwd lng="en"><![CDATA[serologic tests]]></kwd>
</kwd-group>
</article-meta>
</front><back>
<ref-list>
<ref id="B1">
<label>1</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Suardíaz]]></surname>
<given-names><![CDATA[JH.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Fase posanalítica]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[Suardíaz]]></surname>
<given-names><![CDATA[JH]]></given-names>
</name>
<name>
<surname><![CDATA[Cruz]]></surname>
<given-names><![CDATA[CL]]></given-names>
</name>
<name>
<surname><![CDATA[Colina]]></surname>
<given-names><![CDATA[AJ.]]></given-names>
</name>
</person-group>
<source><![CDATA[Laboratorio Clínico]]></source>
<year>2004</year>
<page-range>35-9</page-range><publisher-loc><![CDATA[La Habana ]]></publisher-loc>
<publisher-name><![CDATA[Ciencias Médicas]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B2">
<label>2</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Fernández]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Pruebas diagnósticas]]></article-title>
<source><![CDATA[Bioquímica clínica. Principios y guías para el laboratorio]]></source>
<year>2016</year>
<page-range>186-91</page-range><publisher-loc><![CDATA[La Habana ]]></publisher-loc>
<publisher-name><![CDATA[Editorial de Ciencias Médicas]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B3">
<label>3</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[John]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Lifshitz]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Jhang]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Fink]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Post-analysis: Medical Decision - Making]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[McPherson]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Pincus]]></surname>
<given-names><![CDATA[MR]]></given-names>
</name>
</person-group>
<source><![CDATA[Henry's Clinical Diagnosis and Management by Laboratory Methods]]></source>
<year>2017</year>
<edition>23</edition>
<page-range>68-75</page-range><publisher-loc><![CDATA[Philadelphia ]]></publisher-loc>
<publisher-name><![CDATA[Saunders Elservier]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B4">
<label>4</label><nlm-citation citation-type="book">
<collab>Organización Mundial de la Salud</collab>
<source><![CDATA[Información clave sobre ensayos de laboratorio para COVID 19]]></source>
<year>2020</year>
<publisher-loc><![CDATA[Ginebra ]]></publisher-loc>
<publisher-name><![CDATA[OMS]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B5">
<label>5</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Ashihara]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Kasahara]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Nakamura]]></surname>
<given-names><![CDATA[R.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Immunoassay and Immunochemistry]]></article-title>
<person-group person-group-type="editor">
<name>
<surname><![CDATA[McPherson]]></surname>
<given-names><![CDATA[R]]></given-names>
</name>
<name>
<surname><![CDATA[Pincus]]></surname>
<given-names><![CDATA[MR.]]></given-names>
</name>
</person-group>
<source><![CDATA[Henry's Clinical Diagnosis and Management by Laboratory Methods]]></source>
<year>2017</year>
<edition>23</edition>
<page-range>793-818</page-range><publisher-loc><![CDATA[Philadelphia ]]></publisher-loc>
<publisher-name><![CDATA[Saunders Elservier]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B6">
<label>6.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Mahajan]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Manchikanti]]></surname>
<given-names><![CDATA[L.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Value and validity of coronavirus antibody testing]]></article-title>
<source><![CDATA[Pain Physician]]></source>
<year>2020</year>
<numero>23</numero>
<issue>23</issue>
</nlm-citation>
</ref>
<ref id="B7">
<label>7</label><nlm-citation citation-type="book">
<collab>Assut Europe</collab>
<source><![CDATA[COVID-19 IgG/IgM Rapid Test]]></source>
<year>2020</year>
<publisher-loc><![CDATA[Roma Italia ]]></publisher-loc>
<publisher-name><![CDATA[Assut Europe]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B8">
<label>8</label><nlm-citation citation-type="book">
<collab>Hangzhou Clongene Biotech</collab>
<source><![CDATA[LUNGENE. COVID-19 IgG/IgM Rapid Test and SARS-CoV-2 proteins]]></source>
<year>2020</year>
<publisher-loc><![CDATA[China ]]></publisher-loc>
<publisher-name><![CDATA[Hangzhou Clongene Biotech Co]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B9">
<label>9</label><nlm-citation citation-type="book">
<collab>Guangzhou Wondfo Biotech</collab>
<source><![CDATA[SARS-CoV-2 Antibody Test (Lateral flow method)]]></source>
<year>2020</year>
<publisher-loc><![CDATA[China ]]></publisher-loc>
<publisher-name><![CDATA[Guangzhou Wondfo Biotech]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B10">
<label>10</label><nlm-citation citation-type="book">
<collab>R-Biopharm</collab>
<source><![CDATA[RIDA(r)GENE SARS-CoV-2]]></source>
<year>2020</year>
<publisher-loc><![CDATA[Alemania ]]></publisher-loc>
<publisher-name><![CDATA[R-Biopharm AG]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B11">
<label>11</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Prazuck]]></surname>
<given-names><![CDATA[T]]></given-names>
</name>
<name>
<surname><![CDATA[Colin]]></surname>
<given-names><![CDATA[M]]></given-names>
</name>
<name>
<surname><![CDATA[Giachè]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Gubavu]]></surname>
<given-names><![CDATA[C]]></given-names>
</name>
<name>
<surname><![CDATA[Seve]]></surname>
<given-names><![CDATA[A]]></given-names>
</name>
<name>
<surname><![CDATA[Rzepecki]]></surname>
<given-names><![CDATA[V]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Evaluation of performance of two SARS-CoV-2 Rapid IgM-IgG combined antibody tests on capillary whole blood samples from the fingertip]]></article-title>
<source><![CDATA[PLoS ONE]]></source>
<year>2020</year>
<volume>15</volume>
<numero>9</numero>
<issue>9</issue>
</nlm-citation>
</ref>
<ref id="B12">
<label>12</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Avivar]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Covid 19 Resultados falsos negativos y falsos positivos, los Sistemas de Calidad en nuestros laboratorios clínicos son capaces de detectarlos.]]></article-title>
<source><![CDATA[Diagnóstico in vitro]]></source>
<year>2020</year>
<numero>16</numero>
<issue>16</issue>
</nlm-citation>
</ref>
<ref id="B13">
<label>13</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kiely]]></surname>
<given-names><![CDATA[P]]></given-names>
</name>
<name>
<surname><![CDATA[Hoad]]></surname>
<given-names><![CDATA[VC]]></given-names>
</name>
<name>
<surname><![CDATA[Wood]]></surname>
<given-names><![CDATA[EM.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[False positive viral marker results in blood donors and their unintended consequences]]></article-title>
<source><![CDATA[Vox Sang]]></source>
<year>2018</year>
<volume>113</volume>
<numero>6</numero>
<issue>6</issue>
</nlm-citation>
</ref>
<ref id="B14">
<label>14</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Pérez]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Arce]]></surname>
<given-names><![CDATA[AA]]></given-names>
</name>
<name>
<surname><![CDATA[Macías]]></surname>
<given-names><![CDATA[C.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Respuesta de anticuerpos en la enfermedad por coronavirus 2019]]></article-title>
<source><![CDATA[Rev Cubana Hematol Inmunol Hemoter]]></source>
<year>2020</year>
<volume>36</volume>
<numero>0</numero>
<issue>0</issue>
</nlm-citation>
</ref>
<ref id="B15">
<label>15</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Zhao]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Yuan]]></surname>
<given-names><![CDATA[Q]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[H]]></given-names>
</name>
<name>
<surname><![CDATA[Liu]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Liao]]></surname>
<given-names><![CDATA[X]]></given-names>
</name>
<name>
<surname><![CDATA[Su]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
</person-group>
<source><![CDATA[Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019]]></source>
<year>2020</year>
<publisher-loc><![CDATA[New York ]]></publisher-loc>
<publisher-name><![CDATA[medRxiv (Cold Spring Harbor Laboratory)]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B16">
<label>16</label><nlm-citation citation-type="book">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Tan]]></surname>
<given-names><![CDATA[W]]></given-names>
</name>
<name>
<surname><![CDATA[Lu]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Zhang]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Wang]]></surname>
<given-names><![CDATA[J]]></given-names>
</name>
<name>
<surname><![CDATA[Dan]]></surname>
<given-names><![CDATA[Y]]></given-names>
</name>
<name>
<surname><![CDATA[Tan]]></surname>
<given-names><![CDATA[Z]]></given-names>
</name>
</person-group>
<source><![CDATA[Viral Kinetics and Antibody Responses in Patients with COVID-19]]></source>
<year>2020</year>
<publisher-loc><![CDATA[New York ]]></publisher-loc>
<publisher-name><![CDATA[medRxiv (Cold Spring Harbor Laboratory)]]></publisher-name>
</nlm-citation>
</ref>
<ref id="B17">
<label>17.</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Woloshin]]></surname>
<given-names><![CDATA[S]]></given-names>
</name>
<name>
<surname><![CDATA[Patel]]></surname>
<given-names><![CDATA[N]]></given-names>
</name>
<name>
<surname><![CDATA[Kesselheim]]></surname>
<given-names><![CDATA[AS.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[False negative tests for SARS-CoV-2 infection-challenges and implications]]></article-title>
<source><![CDATA[N Engl J Med]]></source>
<year>2020</year>
<volume>383</volume>
</nlm-citation>
</ref>
<ref id="B18">
<label>18</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Kucirka]]></surname>
<given-names><![CDATA[LM]]></given-names>
</name>
<name>
<surname><![CDATA[Lauer]]></surname>
<given-names><![CDATA[SA]]></given-names>
</name>
<name>
<surname><![CDATA[Laeyendecker]]></surname>
<given-names><![CDATA[O]]></given-names>
</name>
<name>
<surname><![CDATA[Boon]]></surname>
<given-names><![CDATA[D]]></given-names>
</name>
<name>
<surname><![CDATA[Lessler]]></surname>
<given-names><![CDATA[J.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Variation in false-negative rate of Reverse Transcriptase Polymerase Chain Reaction-based SARS-CoV-2 tests by time since exposure]]></article-title>
<source><![CDATA[Ann Intern Med]]></source>
<year>2020</year>
<volume>173</volume>
<numero>4</numero>
<issue>4</issue>
</nlm-citation>
</ref>
<ref id="B19">
<label>19</label><nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name>
<surname><![CDATA[Vizcaíno]]></surname>
<given-names><![CDATA[GJ.]]></given-names>
</name>
</person-group>
<article-title xml:lang=""><![CDATA[Importancia del cálculo de la sensibilidad, la especificidad y otros parámetros estadísticos en el uso de las pruebas de diagnóstico clínico y de laboratorio]]></article-title>
<source><![CDATA[Medicina &amp; Laboratorio]]></source>
<year>2017</year>
<volume>23</volume>
<numero>7-8</numero>
<issue>7-8</issue>
</nlm-citation>
</ref>
</ref-list>
</back>
</article>
