<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1727-897X</journal-id>
<journal-title><![CDATA[MediSur]]></journal-title>
<abbrev-journal-title><![CDATA[Medisur]]></abbrev-journal-title>
<issn>1727-897X</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de Cienfuegos, Centro Provincial de Ciencias Médicas, Provincia de Cienfuegos.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1727-897X2022000300469</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Efectividad del tratamiento neurorrehabilitador integral en la función cognitiva de los pacientes con esclerosis múltiple remitente recurrente]]></article-title>
<article-title xml:lang="en"><![CDATA[Effectiveness of comprehensive neurorehabilitation treatment on the cognitive function of patients with relapsing-remitting multiple sclerosis]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Aurelio Vázquez-Gómez]]></surname>
<given-names><![CDATA[Lázaro]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Hidalgo Mesa]]></surname>
<given-names><![CDATA[Carlos]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Broche-Pérez]]></surname>
<given-names><![CDATA[Yunier]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Hospital Provincial Universitario Clínico-Quirúrgico Arnaldo Milián Castro. Santa Clara  ]]></institution>
<addr-line><![CDATA[Villa Clara ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Hospital Universitario Militar Clínico-Quirúrgico Manuel Piti Fajardo  ]]></institution>
<addr-line><![CDATA[Villa Clara ]]></addr-line>
<country>Cuba</country>
</aff>
<aff id="Af3">
<institution><![CDATA[,Universidad Central de las Villas  ]]></institution>
<addr-line><![CDATA[Villa Clara ]]></addr-line>
<country>Cuba</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>06</month>
<year>2022</year>
</pub-date>
<volume>20</volume>
<numero>3</numero>
<fpage>469</fpage>
<lpage>477</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1727-897X2022000300469&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1727-897X2022000300469&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1727-897X2022000300469&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Fundamento:  las alternativas terapéuticas en pacientes con esclerosis múltiple no deben centrar sus esfuerzos en la rehabilitación de dominios cognitivos específicos, sino valorar el empleo de estrategias de intervención multimodal, con el propósito de minimizar los factores negativos que intervienen en la salud cognitiva de estos.  Objetivo:  determinar la efectividad del tratamiento neurorrehabilitador integral en la función cognitiva de los pacientes con esclerosis múltiple remitente recurrente.  Métodos:  se realizó un estudio cuasiexperimental con dos grupos (un grupo estudio y un grupo control) en pacientes con diagnóstico de esclerosis múltiple remitente recurrente. Cada grupo quedó conformado por 39 pacientes. Los métodos estadísticos exigieron la utilización de un estudio de pruebas repetidas, variante de ANOVA. Para las pruebas de dos momentos se utilizó el concepto de ANOVA de un factor.  Resultados: después de la intervención se obtuvo en el grupo de estudio, un aumento de las puntuaciones en las pruebas de velocidad de procesamiento, memoria de trabajo-flexibilidad cognitiva, fluidez verbal y el control inhibitorio; así como disminución en los niveles de fatiga. Se comprobó una mejoría significativa en el estado emocional del grupo de estudio, pues hubo disminución del estado de ansiedad y depresión.  Conclusiones:  el proceso de neurorrehabilitación integral resultó efectivo al disminuir en los pacientes los niveles de depresión y ansiedad, además de mejorar el funcionamiento cognitivo en el grupo de pacientes que completó el proceso, lo que muestra la viabilidad de un enfoque de neurorrehabilitación integral y su utilidad para mejorar la calidad de vida en adultos con esclerosis múltiple.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Background: Therapeutic alternatives should not focus their efforts on the rehabilitation of specific cognitive domains, but value the use of multimodal intervention strategies, with the purpose of minimizing the negative factors that intervene in the cognitive health of patients with multiple sclerosis.  Objective: to determine the effectiveness of comprehensive neurorehabilitation treatment on the cognitive function of patients with relapsing-remitting multiple sclerosis.  Methods:  a quasi-experimental study was carried out with two groups (a study group and a control group) in patients diagnosed with relapsing-remitting multiple sclerosis. Each group was made up of 39 patients. Statistical methods required the use of a repeated test study, variant of ANOVA. For the two-moment tests, the one-way ANOVA concept was used.  Results: after the intervention, in the study group, an increase in the scores in the tests of processing speed, working memory-cognitive flexibility, verbal fluency and inhibitory control was obtained; as well as decreased levels of fatigue. A significant improvement in the emotional state of the study group was verified, showing a decrease in the state of anxiety and depression.  Conclusions: the comprehensive neurorehabilitation process was effective in reducing depression and anxiety levels in patients, in addition to improving cognitive functioning in the group of patients who completed the process, which shows the viability of a comprehensive neurorehabilitation approach and its effectiveness utility to improve quality of life in adults with multiple sclerosis.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[esclerosis múltiple]]></kwd>
<kwd lng="es"><![CDATA[esclerosis múltiple recurrente-remitente]]></kwd>
<kwd lng="es"><![CDATA[rehabilitación neurológica]]></kwd>
<kwd lng="en"><![CDATA[multiple sclerosis]]></kwd>
<kwd lng="en"><![CDATA[relapsing-remitting multiple sclerosis]]></kwd>
<kwd lng="en"><![CDATA[neurological rehabilitation]]></kwd>
</kwd-group>
</article-meta>
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