<?xml version="1.0" encoding="ISO-8859-1"?><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<front>
<journal-meta>
<journal-id>1727-897X</journal-id>
<journal-title><![CDATA[MediSur]]></journal-title>
<abbrev-journal-title><![CDATA[Medisur]]></abbrev-journal-title>
<issn>1727-897X</issn>
<publisher>
<publisher-name><![CDATA[Universidad de Ciencias Médicas de Cienfuegos, Centro Provincial de Ciencias Médicas, Provincia de Cienfuegos.]]></publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id>S1727-897X2022000500956</article-id>
<title-group>
<article-title xml:lang="es"><![CDATA[Ketamina en el manejo del dolor oncológico]]></article-title>
<article-title xml:lang="en"><![CDATA[Ketamine in cancer pain management]]></article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname><![CDATA[González Pardo]]></surname>
<given-names><![CDATA[Secundino]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[Báez Morales]]></surname>
<given-names><![CDATA[Widmark Enrique]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
<contrib contrib-type="author">
<name>
<surname><![CDATA[López-Muñoz]]></surname>
<given-names><![CDATA[Francisco]]></given-names>
</name>
<xref ref-type="aff" rid="Aff"/>
</contrib>
</contrib-group>
<aff id="Af1">
<institution><![CDATA[,Universidad Técnica del Norte  ]]></institution>
<addr-line><![CDATA[Ibarra ]]></addr-line>
<country>Ecuador</country>
</aff>
<aff id="Af2">
<institution><![CDATA[,Universidad Camilo José Cela  ]]></institution>
<addr-line><![CDATA[Madrid ]]></addr-line>
<country>Spain</country>
</aff>
<pub-date pub-type="pub">
<day>00</day>
<month>10</month>
<year>2022</year>
</pub-date>
<pub-date pub-type="epub">
<day>00</day>
<month>10</month>
<year>2022</year>
</pub-date>
<volume>20</volume>
<numero>5</numero>
<fpage>956</fpage>
<lpage>967</lpage>
<copyright-statement/>
<copyright-year/>
<self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_arttext&amp;pid=S1727-897X2022000500956&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_abstract&amp;pid=S1727-897X2022000500956&amp;lng=en&amp;nrm=iso"></self-uri><self-uri xlink:href="http://scielo.sld.cu/scielo.php?script=sci_pdf&amp;pid=S1727-897X2022000500956&amp;lng=en&amp;nrm=iso"></self-uri><abstract abstract-type="short" xml:lang="es"><p><![CDATA[RESUMEN  Fundamento  la creciente demanda de nuevos analgésicos y sustancias neuromoduladoras en general para el tratamiento del dolor, hace necesario estandarizar el uso de estos. En el caso de la ketamina, la mayoría de las investigaciones giran en torno a su uso en el abordaje de los dolores agudos en situaciones de emergencias médicas.  Objetivo realizar una revisión de la literatura científica actual sobre las potencialidades de la ketamina en el tratamiento del dolor oncológico.  Métodos  se realizó un estudio descriptivo, con diseño no experimental, longitudinal, el cual mediante la revisión documental en torno al tema de la ketamina en el manejo del dolor oncológico, permitió desarrollar una revisión sistemática de artículos científicos publicados en el período 2010-2019. Para ello fue aplicada la metodología Preferred Reporting Items for Systematic reviews and Meta-Analyses, según la cual fue desarrollado el proceso de extracción, búsqueda y elegibilidad de los artículos. Resultados: de un total de 250 artículos encontrados en la búsqueda inicial, fueron seleccionados 6, al considerar los criterios de selección muestral. Los que más se relacionaron con la salida de artículos, fueron el efecto de solapamiento y el temporal. Se obtuvieron respuestas positivas por cualquier vía de administración de la ketamina, excepto la tópica, variante aplicada precisamente en el estudio de mayor alcance.  Conclusión  conforme a la evidencia analizada en el presente trabajo, en tres de los seis estudios evaluados no se confirma la efectividad de la ketamina. No obstante, en dosis subanestésica aún podría considerarse su uso para el manejo del dolor oncológico.]]></p></abstract>
<abstract abstract-type="short" xml:lang="en"><p><![CDATA[ABSTRACT  Background The growing demand for new analgesics and neuromodulatory substances in general for the treatment of pain, makes it necessary to standardize their use. In the case of ketamine, most research revolves around its use in treating acute pain in medical emergencies.  Objective  to carry out a review of the current scientific literature on the potentialities of ketamine in the treatment of cancer pain.  Methods  a descriptive study was carried out, with a non-experimental, longitudinal design, which, through a documentary review on the subject of ketamine in the management of cancer pain, allowed the development of a systematic review of scientific articles published from 2010 to 2019. The Preferred Reporting Items for Systematic reviews and Meta-Analyses methodology was applied, according to which the extraction, search and eligibility process of the articles was developed.  Results  of a total of 250 articles found in the initial search, 6 were selected, considering the sample selection criteria. The ones that were most related to the output of articles were the overlap effect and the temporal effect. Positive responses were obtained by any route of administration of ketamine, except topical, a variant applied precisely in the largest study.  Conclusion  according to the evidence analyzed in this study, the effectiveness of ketamine is not confirmed in three of the six studies evaluated. However, in subanesthetic doses, its use could still be considered for the management of cancer pain.]]></p></abstract>
<kwd-group>
<kwd lng="es"><![CDATA[Ketamina]]></kwd>
<kwd lng="es"><![CDATA[dolor en cáncer]]></kwd>
<kwd lng="es"><![CDATA[manejo del dolor]]></kwd>
<kwd lng="en"><![CDATA[Ketamine]]></kwd>
<kwd lng="en"><![CDATA[cancer pain]]></kwd>
<kwd lng="en"><![CDATA[pain management]]></kwd>
</kwd-group>
</article-meta>
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